List of works - Kristin Ladell

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

scientific article

Monoclonal TCR-redirected tumor cell killing.

scientific article

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

scientific article

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

scientific article

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

scientific article

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

scientific article

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors

scientific article published on 13 December 2010

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

scientific article published on March 2017

TCR -Chain Sharing in Human CD8+ T Cell Responses to Cytomegalovirus and EBV

article

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

scientific article published on 5 March 2015

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

scientific article published on 25 September 2013

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.

scientific article

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

scientific article published on September 2017

Epidermis instructs skin homing receptor expression in human T cells

scientific article published on 4 October 2012

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

scientific article published on June 2008

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

scientific article

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells

scientific article published on May 2015

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion

scientific article published on 7 September 2012

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

scientific article published on 22 August 2017

Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers

scientific article published on November 2008

High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow

scientific article

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

IL-10 restricts memory T cell inflation during cytomegalovirus infection

scientific article published on 16 August 2010

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.

scientific article published on 6 December 2010

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

scientific article

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

scientific article

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

scientific article published on February 2014

The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus

scientific article published on 22 May 2017

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

scientific article published on December 2016

Memory CD4 T cells are generated in the human fetal intestine

scientific article published on 21 January 2019

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiation

scientific article published on 21 November 2012

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

scientific article published on 5 April 2007

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

scientific article published on 25 November 2015

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

Clonality of HTLV-2 in natural infection

scientific article

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

scientific article published on 7 February 2012

Determinants of gliadin-specific T cell selection in celiac disease

scientific article

IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency

scientific article published in June 2004

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia

scientific article

Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.

scientific article published on 20 July 2010

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

scientific article published on 07 February 2019

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

scientific article published on 24 December 2012

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

scientific article published on 25 September 2017

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

scientific article published on 05 September 2013

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

scientific article published on 10 November 2017

List of works by Kristin Ladell

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

Monoclonal TCR-redirected tumor cell killing.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

TCR -Chain Sharing in Human CD8+ T Cell Responses to Cytomegalovirus and EBV

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

Epidermis instructs skin homing receptor expression in human T cells

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers

High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

IL-10 restricts memory T cell inflation during cytomegalovirus infection

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

Memory CD4 T cells are generated in the human fetal intestine

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiation

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Clonality of HTLV-2 in natural infection

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

Determinants of gliadin-specific T cell selection in celiac disease

IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia

Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene