List of works - Kristin Ladell

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

scientific article published on 10 November 2017

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

scientific article

A combination of plasmid DNAs encoding murine fetal liver kinase 1 extracellular domain, murine interleukin-12, and murine interferon-gamma inducible protein-10 leads to tumor regression and survival in melanoma-bearing mice.

scientific article published on 4 April 2003

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

scientific article

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

scientific article published on 01 May 2020

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

scientific article

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

scientific article published on 02 April 2019

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

scientific article published on 25 November 2015

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors

scientific article published on 13 December 2010

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

scientific article

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

scientific article published on 2 February 2018

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

scientific article published on February 2014

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

scientific article published on 01 January 2020

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

scientific article published on 27 September 2016

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

scientific article published on 24 April 2015

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

scientific article published on 24 December 2012

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

scientific article published on 05 September 2013

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

scientific article published on June 2008

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

scientific article published on 07 February 2019

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

scientific article published on March 2017

Clonality of HTLV-2 in natural infection

scientific article

Clonality of HTLV-2 in natural infection

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop

scientific article published in December 2017

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1

scientific article published on 15 October 2014

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease

scientific article

Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4 T Cells

scientific article published on 23 July 2018

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

scientific article published on 22 August 2017

Determinants of gliadin-specific T cell selection in celiac disease

scientific article

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

scientific article published on 7 February 2018

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases

scientific article published on 29 May 2013

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

scientific article

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers

scientific article published on 9 November 2015

Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.

scientific article published on 20 July 2010

Epidermis instructs skin homing receptor expression in human T cells

scientific article published on 4 October 2012

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.

scientific article

Exploring the pre-immune landscape of antigen-specific T cells

scientific article published on 25 August 2018

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

scientific article published on 25 September 2017

HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.

scientific article published on 16 March 2016

High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow

scientific article

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

scientific article published on 25 September 2013

Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiation

scientific article published on 21 November 2012

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

scientific article published on 12 June 2020

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

scientific article published on December 2016

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

scientific article published on 22 June 2018

Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression.

scientific article

IL-10 restricts memory T cell inflation during cytomegalovirus infection

scientific article published on 16 August 2010

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine ⬇️

scientific article published on 01 February 2019

IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency

scientific article published in June 2004

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

scientific article published on 5 April 2007

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

scientific article

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8 T cell-mediated control of HIV-1, HCV, and HTLV-1

article

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia

scientific article

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

scientific article published on 07 June 2018

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

scientific article

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

scientific article

Memory CD4 T cells are generated in the human fetal intestine

scientific article published on 21 January 2019

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

scientific article published on 7 February 2012

Monoclonal TCR-redirected tumor cell killing.

scientific article

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

scientific article published on 12 March 2018

Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.

scientific article published on 6 December 2010

Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1.

scientific article

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

scientific article published on 15 July 2019

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

scientific article

Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics

scientific article

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

scientific article published on 07 March 2016

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

scientific article

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1.

scientific article published on 19 July 2016

Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome

scientific article published on 01 October 2019

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

scientific article published on 5 March 2015

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues

scientific article published on 01 February 2020

Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus

scientific article published on 09 December 2019

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

scientific article published on 12 March 2018

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells

scientific article published on May 2015

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

scientific article

T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion

scientific article published on 7 September 2012

TCR -Chain Sharing in Human CD8+ T Cell Responses to Cytomegalovirus and EBV

article

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

scientific article published on 5 June 2019

Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers

scientific article published on November 2008

The MAIT TCRβ chain contributes to discrimination of microbial ligand

scientific article published on 22 June 2020

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

scientific article published on February 2014

The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus

scientific article published on 22 May 2017

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

scientific article published on 12 October 2020

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

scientific article published on September 2017

Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes

scientific article

Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles

scientific article published on 21 October 2014

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

List of works by Kristin Ladell

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

A combination of plasmid DNAs encoding murine fetal liver kinase 1 extracellular domain, murine interleukin-12, and murine interferon-gamma inducible protein-10 leads to tumor regression and survival in melanoma-bearing mice.

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Clonality of HTLV-2 in natural infection

Clonality of HTLV-2 in natural infection

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease

Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4 T Cells

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Determinants of gliadin-specific T cell selection in celiac disease

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers

Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.

Epidermis instructs skin homing receptor expression in human T cells

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.

Exploring the pre-immune landscape of antigen-specific T cells

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.

High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

Holoendemic malaria exposure is associated with altered Epstein-Barr virus-specific CD8(+) T-cell differentiation

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression.

IL-10 restricts memory T cell inflation during cytomegalovirus infection

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine ⬇️

IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency

Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8 T cell-mediated control of HIV-1, HCV, and HTLV-1

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia

Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

Memory CD4 T cells are generated in the human fetal intestine

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

Monoclonal TCR-redirected tumor cell killing.

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.

Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1.

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1.

Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues

Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells