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List of works by John Petrini

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

scientific article published on 15 June 2016

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

scientific article

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability

scientific article

Association of Mre11p with double-strand break sites during yeast meiosis

scientific article published in February 2004

At the end, remodeling leads to eviction

scientific article published on 01 December 2005

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

scientific article published on September 2002

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

scientific article

Cell signaling. A touching response to damage

scientific article published in May 2007

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

scientific journal article

Checkpoint response to DNA damage.

scientific article

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells

scientific article

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

scientific journal article

Cohesin association to replication sites depends on rad50 and promotes fork restart

scientific article published on 09 August 2012

DNA replication reaches the breaking point.

scientific article published on April 2009

DNA replication-dependent nuclear dynamics of the Mre11 complex.

scientific article

Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model

scientific article published on 4 November 2015

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

scientific article published on January 2009

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

scientific article

Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.

scientific article published on 10 May 2009

Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex

scientific article published on 8 May 2004

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ⬇️

scientific article published on August 29, 2011

Functional interactions between Sae2 and the Mre11 complex.

scientific article

Functions of the MRE11 complex in the development and maintenance of oocytes

scientific article published on August 2015

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

scientific article

Interdependence of the rad50 hook and globular domain functions

scientific article published on 15 January 2015

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway

scientific article published on 07 July 2009

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

scientific article published on December 2010

Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization

scientific article

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

scientific article published on 17 November 2015

Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.

scientific article published on January 2006

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis

scientific article published on 18 March 2020

Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes

scientific article

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication

scientific article

NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.

scientific article

Rad50 is dispensable for the maintenance and viability of postmitotic tissues

scientific journal article

Rad50S alleles of the Mre11 complex: questions answered and questions raised

scientific article published on 20 June 2006

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

scientific article published on April 2009

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation

scientific article published on July 2005

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy

scientific article published on 16 June 2014

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding

scientific article

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

scientific article

The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks

scientific article published on 13 June 2013

The MRE11 complex: starting from the ends.

scientific article published on February 2011

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis

scientific journal article

The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.

scientific article published on 10 October 2013

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

scientific article

The Rad50 hook domain is a critical determinant of Mre11 complex functions

scientific article published on 24 April 2005

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

scientific article published on 14 February 2014

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

scientific article

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

scientific article

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

scholarly article

The mre11 complex and the response to dysfunctional telomeres

scientific article published on 10 August 2009

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

scientific article

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

scientific article

Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma ⬇️

scientific article published on October 1, 2012

Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.

scientific article published on 22 December 2008

ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over

scientific journal article

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