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List of works by Fred van Leeuwen

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

scientific article

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover

scientific article

A genetic interaction map centered on cohesin reveals auxiliary factors in sister chromatid cohesion

scientific article published on 16 April 2020

A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast

scientific article published in 2012

A modified epigenetics toolbox to study histone modifications on the nucleosome core.

scientific article published on 29 December 2010

A network model of the molecular organization of chromatin in Drosophila

scientific article published on February 2013

A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma

scientific article published on 01 December 2019

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

scientific article

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

scientific article published on 31 March 2020

CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

scientific article published on 04 December 2019

CD8– dendritic cells preferentially cross-presentSaccharomyces cerevisiae antigens

scientific article published on 01 February 2008

Chemical biology approaches to probe the proteome.

scientific article published on December 2008

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma

scientific article published on 17 June 2019

Crosstalk between aging and the epigenome

scientific article published on 01 February 2012

Decoding the chromatin proteome of a single genomic locus by DNA sequencing

scientific article published on 13 July 2018

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

scientific article (publication date: 6 December 2016)

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.

scientific article published on 3 February 2011

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

scientific article

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

scientific article published on 01 November 2018

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.

scientific article published on 16 December 2017

Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq

scientific article published on 01 January 2019

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

scientific article published on 20 August 2014

Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei

scientific article published on December 2010

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

scientific article published on 07 January 2021

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

scientific article published on 18 March 2020

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila

scientific article

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae

scientific article

Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.

scientific article published on 9 March 2009

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

scientific article published on 20 November 2014

News about old histones: A role for histone age in controlling the epigenome

scientific article published on 01 January 2012

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

scientific article published on 30 May 2008

Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.

scientific article published on 7 June 2011

Progressive methylation of ageing histones by Dot1 functions as a timer.

scientific article published on September 2011

Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae

scientific article published on 7 August 2013

Recombination-induced tag exchange to track old and new proteins

scientific article

Spatiotemporal analysis of organelle and macromolecular complex inheritance

scientific article published on 17 December 2012

The emerging roles of DOT1L in leukemia and normal development

scientific article published on 23 May 2014

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

scientific article published on 06 August 2020

The modified DNA base beta-D-glucosylhydroxymethyluracil confers resistance to micrococcal nuclease and is incompletely recovered by 32P-postlabeling

scientific article published on 01 May 1998

The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans

scientific article

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

scientific article

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