List of works by Neekesh Dharia

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

scientific article published on 8 September 2011

A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma

scientific article published on 05 November 2018

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

scientific article published on 17 March 2022

A first-generation pediatric cancer dependency map

scientific article published on 22 March 2021

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

scientific article

Answer to May 2015 Photo Quiz

scientific article published on 16 April 2015

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis

scientific article published on 01 September 2018

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

scientific article

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

scientific article published on 01 March 2022

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

scientific article published on 18 January 2018

Esterase mutation is a mechanism of resistance to antimalarial compounds

scientific article (publication date: 20 January 2017)

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

scientific article published on 07 June 2021

Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites

scientific article

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

scientific article published on 25 July 2018

Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes

scientific article

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

scientific article (publication date: 9 December 2011)

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

scientific article published on 12 February 2019

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

scientific article

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

scientific article published on 21 January 2021

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

Photo quiz: A child with fever after hematopoietic stem cell transplantation

scientific article

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

scientific article

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

scientific article published on 01 September 2018

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

publication published on 21 April 2021

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

scientific article published on 22 May 2018

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

scientific article

Validation of isoleucine utilization targets in Plasmodium falciparum

scientific article (publication date: 25 January 2011)

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

scientific article

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