List of works - Douglas Palmer

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

scientific article

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

scientific article published on 17 September 2008

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

scientific article published on 24 September 2009

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

scientific article

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

scientific article published on 09 May 2016

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

scientific article

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

scientific article

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

scientific article

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

scientific article published on 09 April 2013

Cross-priming utilizes antigen not available to the direct presentation pathway.

scientific article published on 8 June 2006

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

scientific article

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

scholarly article

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

scientific article

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

scientific article published in March 2018

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

scientific article published on February 2007

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

scientific article

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

scientific article

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

scientific article published on March 2010

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

scientific article

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

scientific article published on 14 February 2008

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

scientific article

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen

scientific article

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

scientific article published on January 2010

Inflammatory mediator production in swine following endotoxin challenge with or without co-administration of dexamethasone.

scientific article published on April 2003

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

scientific article published on 16 September 2013

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

scientific article published on 13 September 2012

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

scientific article published on 14 September 2016

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

scientific article

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

scientific article published on 14 December 2015

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

scientific article published on April 2013

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

scientific article published in August 2007

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

scientific article published on 7 December 2015

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

scientific article published on May 2009

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

scientific article

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

scientific article published on 26 June 2009

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

scientific article

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

scientific article published on 02 September 2013

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.

scientific article

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

scientific article

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

scientific article published on 30 October 2009

T cell stemness and dysfunction in tumors are triggered by a common mechanism

scientific article

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

scientific journal article

Th17 cells are long lived and retain a stem cell-like molecular signature

scientific article

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

scientific article published on 28 March 2018

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

scientific article

The transcription factor BACH2 promotes tumor immunosuppression.

scientific article published on 5 January 2016

Toll-like receptors in tumor immunotherapy

scientific article

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity ⬇️

scientific article published on November 15, 2010

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

scientific article

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

scientific article

Tumor-specific Th17-polarized cells eradicate large established melanoma

scientific article

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

scientific article

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells

scientific article

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

scientific article

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

scientific article

List of works by Douglas Palmer

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

Cross-priming utilizes antigen not available to the direct presentation pathway.

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

Inflammatory mediator production in swine following endotoxin challenge with or without co-administration of dexamethasone.

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

T cell stemness and dysfunction in tumors are triggered by a common mechanism

T-cell receptor gene therapy of established tumors in a murine melanoma model

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

Th17 cells are long lived and retain a stem cell-like molecular signature

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

The in vivo expansion rate of properly stimulated transferred CD8+ T cells exceeds that of an aggressively growing mouse tumor.

The transcription factor BACH2 promotes tumor immunosuppression.

Toll-like receptors in tumor immunotherapy

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity ⬇️

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

Tumor-specific Th17-polarized cells eradicate large established melanoma

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.