Search filters

List of works by Karl-Wilhelm Koch

A Calcium-Relay Mechanism in Vertebrate Phototransduction ⬇️

scientific article (publication date: 19 June 2013)

A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration

scientific article published on 08 January 2019

A comprehensive model of the phototransduction cascade in mouse rod cells

scientific article published on 28 March 2014

A dynamic scaffolding mechanism for rhodopsin and transducin interaction in vertebrate vision ⬇️

scientific article published on 01 December 2011

Antithetical modes of and the Ca(2+) sensors targeting in ANF-RGC and ROS-GC1 membrane guanylate cyclases.

scientific article published on 9 April 2012

Application of different surface plasmon resonance biosensor chips to monitor the interaction of the CaM-binding site of nitric oxide synthase I and calmodulin

scientific article published in July 2001

Bifunctional Diaminoterephthalate Fluorescent Dye as Probe for Cross-Linking Proteins

scientific article

Biochemical mechanism of light adaptation in vertebrate photoreceptors.

scientific article

Biophysical investigation of retinal calcium sensor function ⬇️

scientific article published on October 13, 2011

Bovine retinal rod guanyl cyclase represents a new N-glycosylated subtype of membrane-bound guanyl cyclases.

scientific article published on June 1994

Ca(2+) sensor S100beta-modulated sites of membrane guanylate cyclase in the photoreceptor-bipolar synapse

scientific article published on June 2002

Ca(2+)-modulated vision-linked ROS-GC guanylate cyclase transduction machinery.

scientific article

Ca2+-dependent conformational changes in the neuronal Ca2+-sensor recoverin probed by the fluorescent dye Alexa647

scientific article published on 01 February 2007

Ca2+-myristoyl switch in the neuronal calcium sensor recoverin requires different functions of Ca2+-binding sites.

scientific article published on 21 October 2002

CaF2 nanoparticles as surface carriers of GCAP1, a calcium sensor protein involved in retinal dystrophies.

scientific article published on 8 August 2017

Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy

scientific article published in March 2010

Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and protein-2

scientific article (publication date: 29 October 2002)

Calcium-dependent binding of recoverin to membranes monitored by surface plasmon resonance spectroscopy in real time

scientific article published in October 1997

Calcium-dependent conformational changes in guanylate cyclase-activating protein 2 monitored by cysteine accessibility

scientific article published on 12 March 2007

Calcium-modulated guanylate cyclase transduction machinery in the photoreceptor--bipolar synaptic region

scientific article published in May 2003

Calcium-modulated membrane guanylate cyclase in synaptic transmission?

scientific article

Calcium‐dependent cysteine reactivities in the neuronal calcium sensor guanylate cyclase‐activating protein 1 ⬇️

scientific article published on November 23, 2001

Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N-terminus of the beta-subunit.

scientific article published on April 1998

Conformational changes in calcium-sensor proteins under molecular crowding conditions

Control of photoreceptor proteins by Ca2+.

scientific article published on October 1995

Cyclic GMP releases calcium from leaky rod outer segments

scientific article published on 01 January 1984

Diaminoterephthalate turn-on fluorescence probes for thiols--tagging of recoverin and tracking of its conformational change

scientific article

Differential Nanosecond Protein Dynamics in Homologous Calcium Sensors

scientific article published on 07 August 2015

Differential calcium signaling by cone specific guanylate cyclase-activating proteins from the zebrafish retina

scientific article

Distinct molecular recognition of calmodulin-binding sites in the neuronal and macrophage nitric oxide synthases: a surface plasmon resonance study

scientific article published in July 1996

Divalent cations modulate membrane binding and pore formation of a potent antibiotic peptide analog of alamethicin

scientific article published on 20 December 2012

Diversity of sensory guanylate cyclases in teleost fishes

scientific article

Dynamic cellular translocation of caldendrin is facilitated by the Ca2+-myristoyl switch of recoverin

scientific journal article

Dynamics of Conformational Ca2+-Switches in Signaling Networks Detected by a Planar Plasmonic Device

article

Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations

scientific article published on 26 February 2014

Erratum: Retina specific GCAPs in zebrafish acquire functional selectivity in Ca(2+)-sensing by myristoylation and Mg(2+)-binding

scientific article published on 2 September 2015

Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling

scientific article published on 21 May 2013

Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments

scientific article

Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina

scientific article published on 6 January 2009

Fingerprints of Calcium-Binding Protein Conformational Dynamics Monitored by Surface Plasmon Resonance

scientific article

Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant

scientific article

Genotype-functional-phenotype correlations in photoreceptor guanylate cyclase (GC-E) encoded by GUCY2D.

scientific article

Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1

scientific article published on 01 May 2000

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions.

scientific article

Impact of N-terminal myristoylation on the Ca2+-dependent conformational transition in recoverin

scientific article (publication date: 20 June 2003)

Impact of cone dystrophy-related mutations in GCAP1 on a kinetic model of phototransduction

scientific article published on 25 February 2014

Impact of strong and weak lipid-protein interactions on the structure of a lipid bilayer on a gold electrode surface

scientific article published on 25 March 2011

Impact of the protein myristoylation on the structure of a model cell membrane in a protein bound state

scientific article published on 25 June 2018

Impairment of the rod outer segment membrane guanylate cyclase dimerization in a cone-rod dystrophy results in defective calcium signaling.

scientific article

Incorporating phototransduction proteins in zebrafish green cone with pressure-polished patch pipettes

scientific article published on 22 July 2019

Introduction of a phosphate at serine741 of the calmodulin-binding domain of the neuronal nitric oxide synthase (NOS-I) prevents binding of calmodulin

scientific article published in August 1997

Involvement of the calcium sensor GCAP1 in hereditary cone dystrophies

scientific article published on June 2010

Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase

scientific article published in April 2011

Irregular dimerization of guanylate cyclase-activating protein 1 mutants causes loss of target activation

scientific article published in September 2004

Mapping Calcium-Sensitive Regions in GCAPs by Site-Specific Fluorescence Labelling

scientific article published on 01 January 2019

Mechanism of rhodopsin kinase regulation by recoverin

scientific article

Molecular Recognition of Rhodopsin Kinase GRK1 and Recoverin Is Tuned by Switching Intra- and Intermolecular Electrostatic Interactions

scientific article published on 21 October 2019

Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase

scientific article published in August 2009

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

scientific article

On-chip photoactivation of heterologously expressed rhodopsin allows kinetic analysis of G-protein signaling by surface plasmon resonance spectroscopy

scientific article

One of the Ca2+ binding sites of recoverin exclusively controls interaction with rhodopsin kinase

scientific article

Operation profile of zebrafish guanylate cyclase-activating protein 3.

scientific article published in April 2012

Phosphorylation of recoverin, the calcium-sensitive activator of photoreceptor guanylyl cyclase

scientific article published in December 1991

Photoreceptor specific guanylate cyclases in vertebrate phototransduction

scientific article

Probing the Ca(2+) switch of the neuronal Ca(2+) sensor GCAP2 by time-resolved fluorescence spectroscopy

scientific article published on 26 March 2012

Protein and Signaling Networks in Vertebrate Photoreceptor Cells

scientific article

Purified retinal nitric oxide synthase enhances ADP-ribosylation of rod outer segment proteins

scientific article published on 01 January 1995

Quantitative detection of conformational transitions in a calcium sensor protein by surface plasmon resonance

scientific article published on 10 September 2010

Recoverin and rhodopsin kinase activity in detergent-resistant membrane rafts from rod outer segments

scientific article published on 7 September 2004

Recoverin, a novel calcium-binding protein from vertebrate photoreceptors

scientific article published in November 1992

Regions in vertebrate photoreceptor guanylyl cyclase ROS-GC1 involved in Ca(2+)-dependent regulation by guanylyl cyclase-activating protein GCAP-1.

scientific article

Regulatory function of the C-terminal segment of guanylate cyclase-activating protein 2.

scientific article

Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca(2+)-sensitivity

scientific article published on September 2003

Retina specific GCAPs in zebrafish acquire functional selectivity in Ca2+-sensing by myristoylation and Mg2+-binding

scientific article published on 10 June 2015

Retinal diseases linked with photoreceptor guanylate cyclase

scientific article

Structural effects of Mg²⁺ on the regulatory states of three neuronal calcium sensors operating in vertebrate phototransduction.

scientific article

Surface plasmon resonance study of g protein/receptor coupling in a lipid bilayer-free system

scientific article published on 01 February 2006

Synergetic effect of recoverin and calmodulin on regulation of rhodopsin kinase

scientific article published on 8 March 2012

Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease ⬇️

scientific article published on October 1, 2010

Target recognition of apocalmodulin by nitric oxide synthase I peptides

scientific article published on 01 July 2002

The calcium-sensor guanylate cyclase activating protein type 2 specific site in rod outer segment membrane guanylate cyclase type 1.

scientific article published in May 2005

The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina

scientific article published on 6 September 2008

The dimerization domain in outer segment guanylate cyclase is a Ca²⁺-sensitive control switch module

scientific article published on 17 July 2013

The guanylate cyclase signaling system in zebrafish photoreceptors ⬇️

scientific article published on 07 May 2013

The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes

scientific article published on 13 October 2014

Thermodynamics of apocalmodulin and nitric oxide synthase II peptide interaction

scientific article published on 01 November 2004

Transient complexes between dark rhodopsin and transducin: circumstantial evidence or physiological necessity?

scientific article published on February 2015

Tuning of a neuronal calcium sensor

scientific article

Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors

scientific article

Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization

scientific article published on 9 April 2015

Paulina is supported by:

About Paulina

Help