List of works by Tara L Spires-Jones

A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice

scientific article published on October 2009

A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model

scientific article published on 22 May 2009

APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

scientific article published on 28 November 2018

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

scientific article published on 24 December 2006

Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling

scientific article

Alzheimer's disease: synapses gone cold

scientific article published on 26 August 2011

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

scientific article

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

scientific article

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

scientific article

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

scientific article published on 26 April 2016

An epigenetic predictor of death captures multi-modal measures of brain health

scientific article published on 03 December 2019

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer's Disease and Type 2 Diabetes

scientific article published on 9 December 2017

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

scientific article

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

scientific article

Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain

scientific article

Are tangles as toxic as they look?

scientific article

Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.

scientific article

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

scientific article

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

scientific article published on 4 December 2010

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

scientific article published on 21 October 2010

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes

scientific article

Caspase activation precedes and leads to tangles

scientific article

Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

scientific article published on 27 July 2020

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

scientific article published on 28 November 2019

Clearing the way for tau immunotherapy in Alzheimer's disease.

scientific article published on 23 August 2014

Clusterin accumulates in synapses in Alzheimer's disease and is increased in apolipoprotein E4 carriers

scientific article published on 24 June 2019

Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype

scientific article published on 20 December 2019

Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

scientific article published on 20 October 2017

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

scientific article published on August 2005

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

scientific article published on May 2004

Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice.

scientific article published on 21 June 2013

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

scientific article

Editorial

scientific article published on 13 January 2020

Editorial June 2020

scientific article published on 04 August 2020

Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.

scientific article

Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease

scientific article published in August 2010

Epigenetic predictors of lifestyle traits applied to the blood and brain

scientific article published in 2021

Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse.

scientific article published on 9 December 2015

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.

scientific article

Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain

scientific article

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

scientific article published on 24 November 2020

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.

scientific article published on 3 November 2017

Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease

scientific article published on 17 October 2016

Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model

scientific article

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

scientific article published on 01 January 2008

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

scientific article published on 12 March 2012

Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease

scientific article published on February 2012

Interactions of pathological proteins in neurodegenerative diseases

scientific article published on 11 April 2017

Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau

scientific article published on 29 July 2020

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

scientific article published on 21 January 2014

Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia

scientific article published on 06 September 2020

Modeling Alzheimer’s disease brains in vitro

scientific article published on 01 July 2018

Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

scientific article published on 8 January 2007

Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging

scientific article

Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

scientific article published on 7 November 2011

Nanoscale structure of amyloid-β plaques in Alzheimer's disease

scientific article published on 26 March 2019

Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw

scientific article

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

scientific article

Neurofibrillary tangles remain functionally integrated in cortical networks

Neuronal structure is altered by amyloid plaques

scientific article

Neuropathology of Alzheimer's disease.

scientific article published in January 2008

Non-Fibrillar Oligomeric Amyloid-β within Synapses

scientific article published on 30 May 2016

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

scientific article

Opening up: open access publishing, data sharing, and how they can influence your neuroscience career

scientific article published on 7 March 2016

Opposing Roles of apolipoprotein E in aging and neurodegeneration

scientific article published on 13 February 2019

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

scientific article

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

scientific article published on 6 November 2008

Pathological tau disrupts ongoing network activity

scientific article

Pathology of synapses and dendritic spines

scientific article published on 23 September 2012

Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

scientific article

Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease

scientific article published on 07 October 2020

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease

scientific article

Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets

scientific article published on 23 October 2013

Propagation of tau pathology in a model of early Alzheimer's disease

scientific article (publication date: 23 February 2012)

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

scientific article published on February 2008

Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice

scientific article published on April 2013

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

scientific article published on 10 January 2022

Reflections on the past two decades of neuroscience

scientific article published on 02 September 2020

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease

scientific article published on 06 September 2018

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

scientific article

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

scientific article

Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease

scientific article published on August 2013

Selective vulnerability of inhibitory networks in multiple sclerosis

scientific article published on 15 January 2021

Soluble forms of tau are toxic in Alzheimer's disease

scientific article

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

scientific article

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model

scientific article published on July 2011

Spine tingling polymorphisms--is apolipoprotein E involved in dendritic shape and plasticity?

scientific article published on 9 October 2006

Spines, plasticity, and cognition in Alzheimer's model mice

scientific article

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

scientific article

Studying synapses in human brain with array tomography and electron microscopy

scientific article

Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration

scientific article

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

scientific article published on 22 December 2017

Synaptic alterations in the rTg4510 mouse model of tauopathy

scientific article published on April 2013

Synaptic pathology: A shared mechanism in neurological disease

scientific article published on 20 April 2016

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.

scientific article published on 21 November 2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

scientific article published on 31 January 2018

T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice

scientific article published on 9 March 2011

TAR-DNA Binding Protein 43 in Pick Disease

scientific article published on 01 January 2008

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

scientific article

Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy

scientific article

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain

scientific journal article

Tau association with synaptic vesicles causes presynaptic dysfunction

scientific article

Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy

scientific article

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

scientific article

Tau pathophysiology in neurodegeneration: a tangled issue

scientific article published on 21 January 2009

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology

scientific article published on December 2013

The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.

scientific article

The intersection of amyloid beta and tau at synapses in Alzheimer's disease

scientific article

The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease.

scientific article published on 22 March 2013

The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

scientific article published on 29 July 2020

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

scientific article

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

article by Anna J Stevenson et al published 20 December 2018 in Clinical epigenetics

Transgenic models of Alzheimer's disease: learning from animals

scientific article

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

scientific article published in 2024

Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.

scientific article published in January 2008

Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

scientific article

You are not alone: selecting your group members and leading an outstanding research team

scientific article published on 27 November 2015

[Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease].

scientific article published in October 2010

Paulina is supported by:

About Paulina

Help