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List of works by Ben Wielockx

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

scientific article published in August 2005

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.

scientific article published on 6 August 2018

Cancer Stem Cells in Pheochromocytoma and Paraganglioma

scientific article published on 25 February 2020

Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury

scientific article

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes

scientific article

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

scientific article published on 19 November 2018

Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock

scientific article published in April 2007

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor

scientific article

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation

scientific article published on 26 August 2021

Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow

scientific article published on 7 February 2018

Erythrocytosis: the HIF pathway in control.

scientific article published on 03 June 2013

Erythropoietin Mediated Bone Loss in Mice Is Dose-Dependent and Mostly Irreversible

scientific article published on 27 May 2020

Erythropoietin directly stimulates osteoclast precursors and induces bone loss

scientific article published on 28 January 2015

Erythropoietin receptor in B cells plays a role in bone remodeling in mice

scientific article published on 09 July 2020

Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation

scientific article published on 21 March 2019

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

scientific article

HIF in vascular development and tumour angiogenesis.

scientific article

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

scientific article published on 10 May 2013

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation

scientific article

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

scientific article published in February 2016

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis

scientific article

HIF1α is a direct regulator of steroidogenesis in the adrenal gland

scientific article published on 19 January 2021

HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomas

scientific article published on 01 November 2020

HSP70 protects against TNF-induced lethal inflammatory shock

scientific article published in May 2002

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

scientific article published on 16 December 2016

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

scientific article published on 10 May 2018

Hematopoietic hypoxia-inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis

scientific article published on 29 August 2018

Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases

scientific article published on 21 August 2019

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

scientific article

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy

scientific article

Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment

scientific article published on 29 January 2018

Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis

scientific article published on 30 October 2020

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

scientific article published on 13 February 2019

Hypoxia-inducible factors as key regulators of tumor inflammation

scientific article published on 2 November 2012

Hypoxia-mediated regulation of stem cell fate

scientific article published on September 2012

Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.

scientific article published in February 1999

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells

scientific article

Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders

scientific article published in 2022

Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ

scientific article

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

scientific article published in November 2001

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

scientific article published on 01 October 2020

Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling

scientific article published on 24 February 2017

Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression

scientific article

Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor

scientific article published in October 2001

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice

scientific article published in September 2007

Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice

scientific article published on 24 June 2013

Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.

scientific article

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization

scientific article

Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation?

scientific article published on April 2004

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

scientific article published in January 2018

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia

scientific article published on 28 August 2012

Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.

scientific article published on 3 January 2012

PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages

scientific article published on 17 October 2016

PHD2: from hypoxia regulation to disease progression

scientific article

PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling

PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.

scientific article published on 18 September 2013

Regulation of endothelial migration and proliferation by ephrin-A1.

scientific article published on 11 October 2016

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis

scientific article

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

scientific article

Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumor necrosis factor

scientific article published in March 2003

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

scientific article

The ACE-2 in COVID-19: Foe or Friend?

scientific article published on 27 April 2020

The role of complement activation in tumour necrosis factor-induced lethal hepatitis

scientific article published in August 1999

The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferon gamma antitumor therapy

scientific article

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