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List of works by Gregg E. Homanics

A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development

scientific article published in 2021

A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse

scientific article published in February 2005

A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol

scientific article published on 10 December 2006

A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity

scientific article published on 22 October 2021

Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation

scientific article

Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury.

scientific article published on 29 August 2009

Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice

scientific article

Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury

scientific article published in April 2006

Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors.

scientific article

Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear

scientific article published on 15 April 2005

Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors

scientific article

Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit

scientific article

Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines.

scientific article

Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout mice

scientific article

Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits.

scientific article

Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation

scientific journal article

An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice

scientific article (publication date: October 2006)

Anesthesia Sensitivity in Mice that Lack the β3 Subunit of the γ-Aminobutyric Acid Type A Receptor

scientific article published on March 1, 1998

Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.

scientific article published on October 1999

Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.

scientific article

Brain regional heterogeneity of pH effects on GABA(A) receptor-associated [35s]TBPS binding

scientific article published in April 2004

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

scientific article published on 28 October 2011

Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity

scientific article

Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.

scientific article published on 21 January 2011

Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice.

scientific article published in April 2006

Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.

scientific article published on 11 February 2003

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.

scientific article published on 6 December 2007

Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice

scientific article published on 17 May 2006

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease

scientific article published on 17 March 2009

Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse

scientific article published in June 2001

Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane

scientific article

Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring

scientific article published on 22 September 2020

Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus

scientific article published on 13 May 2008

Exencephaly and hydrocephaly in mice with targeted modification of the Apolipoprotein B (Apob) gene

article

Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells

scientific article published on 7 December 2007

Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.

scientific article

GABA influences the development of the ventromedial nucleus of the hypothalamus.

scientific article published in December 2001

GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.

scientific article published in September 2002

GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration

scientific article

GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain

scientific article published in April 2002

GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons.

scientific article published in September 2002

GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice

scientific article published on 21 February 2006

GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

scientific journal article

GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior

scientific article published in June 2005

GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines.

scientific article

GABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol

scientific article published on 24 September 2013

Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder

scientific article

Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.

scientific article published on 03 August 2011

Gene-edited CRISPy Critters for alcohol research

scientific article published on 07 March 2018

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

scientific article

Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.

scientific article published on March 2005

Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.

scientific article

Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).

scientific article published on 19 August 2009

Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease

scientific article published on 12 May 2009

Hypoplasia of spiral and Scarpa's ganglion cells in GABA(A) receptor beta(3) subunit knockout mice.

scientific article

Increased acute cocaine sensitivity and decreased cocaine sensitization in GABA(A) receptor beta3 subunit knockout mice

scientific article

Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors

scientific article published on March 2009

Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.

scientific article published on March 2003

Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline

scientific article published on 26 April 2019

Investigation of ethanol-induced impairment of spatial memory in gamma2 heterozygous knockout mice.

scientific article

Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice.

scientific article published on 8 November 2005

Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.

scientific article published on 09 October 2008

Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol

scientific article published on 19 June 2006

Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.

scientific article published on 22 February 2012

Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor

scientific article published on 20 May 2011

Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

scientific article published on 9 November 2012

Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life

scientific article published in August 2005

Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

scientific article

MAP2 is differentially phosphorylated in schizophrenia, altering its function

scientific article published on 01 February 2021

Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.

scientific article

Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines

scientific article published in June 2000

Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks

scientific article published on 26 July 2008

Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene

scientific article published on 01 February 1995

Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice

scientific article published in September 2002

Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABA(A) receptor alterations

scientific article published in April 2003

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

scientific article

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice

scientific article

New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout

scientific article

Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.

scientific article

Paternal Preconception Every-Other-Day Ethanol Drinking Alters Behavior and Ethanol Consumption in Offspring

scientific article published on 06 March 2019

Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

scientific article published on 5 November 2016

Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice.

scientific article published on 22 April 2016

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

scientific article published on 26 October 2013

Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines

scientific article published on May 1999

Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome

scientific article published in December 2005

Pre- and postsynaptic GABA receptors at reciprocal dendrodendritic synapses in the olfactory bulb.

scientific article published in December 2004

Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.

scientific article

Production and characterization of murine models of classic and intermediate maple syrup urine disease

scientific article

Production of conditional point mutant knockin mice

scientific article published on 01 July 2006

Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.

scientific article

Reciprocal inhibitory connections and network synchrony in the mammalian thalamus

scientific article

Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit

scientific article published on 17 April 2003

Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor

scientific article published on 01 May 2020

Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor.

scientific article published in January 2000

Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor

scientific article published in November 2002

Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder

scientific article

Subunit Compensation and Plasticity of Synaptic GABAA Receptors Induced by Ethanol in ?4 Subunit Knockout Mice

scientific article published on September 23, 2011

T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.

scientific article published on 12 June 2010

Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer

scientific article

Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells

scientific journal article

Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.

scientific article published on January 2008

Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

scientific article published on 5 November 2010

The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors

scientific article published in March 2007

The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

scientific article

The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

scientific article

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

scientific journal article

Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation

scientific article

Tonic for what ails us? high-affinity GABAA receptors and alcohol

scientific article

Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.

scientific article published in May 2006

delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol

scientific article published on 17 May 2006