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List of works by Sheng Chen

A DNA microarray for identification of virulence and antimicrobial resistance genes in Salmonella serovars and Escherichia coli

scientific article published in June 2005

A Novel PCR-Based Approach for Accurate Identification of Vibrio parahaemolyticus.

scientific article published on 28 January 2016

A Siderophore-Encoding Plasmid Encodes High-Level Virulence in Escherichia coli

scientific article published in 2022

A conjugative plasmid that augments virulence in Klebsiella pneumoniae

scientific article published on 30 September 2019

A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study.

scientific article published on 29 August 2017

A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity.

scientific article published on 23 October 2014

A novel adhesive factor contributing to the virulence of Vibrio parahaemolyticus.

scientific article

A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection

scientific article

Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli

scientific article published in 2021

Application of CRISPR/Cas9-Based Genome Editing in Studying the Mechanism of Pandrug Resistance in Klebsiella pneumoniae

scientific article published on 24 June 2019

Association of Botulinum Neurotoxin Serotype A Light Chain with Plasma Membrane-bound SNAP-25 ⬇️

scientific article published on March 4, 2011

Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor

scientific article published on 24 November 2018

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

scientific article published on 23 March 2015

Carriage of blaKPC-2 by a virulence plasmid in hypervirulent Klebsiella pneumoniae

scientific article published on 01 December 2018

Characterisation of a chromosomally-encoded extended-spectrum β-lactamase gene blaPER-3 in Aeromonas caviae of chicken origin

article

Characterisation of a cointegrate plasmid harbouring blaNDM-1 in a clinical Salmonella Lomita strain

scientific article published on 07 October 2019

Characterization of Protein Domain Function via <i>in vitro</i> DNA Shuffling

publication published on 05 June 2018

Characterization of Salmonella food isolates with concurrent resistance to ceftriaxone and ciprofloxacin

scientific article published in January 2013

Characterization of a novel zinc transporter ZnuA acquired by Vibrio parahaemolyticus through horizontal gene transfer

scientific article published on 10 October 2013

Characterization of an IncA/C Multidrug Resistance Plasmid in Vibrio alginolyticus.

scientific article published on 14 March 2016

Characterization of extended-spectrum β-lactamases (ESBLs)-producing Salmonella in retail raw chicken carcasses

scientific article published on 24 February 2017

Characterization of extended-spectrum-β-lactamase-producing Vibrio parahaemolyticus

scientific article published on 16 April 2012

Characterization of multidrug-resistant Proteus mirabilis isolated from chicken carcasses

scientific article published on 25 January 2013

Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China.

scientific article published on August 2004

Characterization of multiple-antimicrobial-resistant salmonella serovars isolated from retail meats

scientific article published on January 2004

Chromosomal and plasmid-borne tigecycline resistance genes tet(X3) and tet(X4) in dairy cows in a Chinese farm

scientific article published on 17 August 2020

Clostridial neurotoxins: mode of substrate recognition and novel therapy development.

scientific article published on January 2014

Coexistence of Antibiotic Resistance Genes and Virulence Factors Deciphered by Large-Scale Complete Genome Analysis

scientific article published on 02 June 2020

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014-2019

scientific article published on 29 January 2020

Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes.

scientific article published on August 2016

Comparative Study on Antibiotic Resistance and DNA Profiles of Salmonella enterica Serovar Typhimurium Isolated from Humans, Retail Foods, and the Environment in Shanghai, China.

scientific article

Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms

scientific article published on 31 December 2015

Comparative characterization of nontyphoidal Salmonella isolated from humans and food animals in China, 2003-2011.

scientific article

Complete Sequence of a F33:A-:B- Conjugative Plasmid Carrying the oqxAB, fosA3, and blaCTX-M-55 Elements from a Foodborne Escherichia coli Strain.

scientific article published on 27 October 2016

Complete genetic analysis of plasmids carrying mcr-1 and other resistance genes in an Escherichia coli isolate of animal origin.

scientific article published on 20 December 2016

Complete nucleotide sequence of a conjugative plasmid carrying bla(PER-1).

scientific article published on 16 March 2015

Conjugation of Virulence Plasmid in Clinical Klebsiella pneumoniae Strains through Formation of a Fusion Plasmid

scientific article published on 13 February 2020

Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials

scientific article published on 16 October 2006

Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation

scientific article published on 02 June 2020

Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance.

scientific article published on 13 December 2016

Development of a Novel Quantum Dots and Graphene Oxide Based FRET Assay for Rapid Detection of invA Gene of Salmonella

scientific article published on 17 January 2017

Dissemination of IncI2 Plasmids That Harbor the blaCTX-M Element among Clinical Salmonella Isolates

scientific article published on 26 May 2015

Dissemination of the mcr-1 colistin resistance gene

Distinct mechanisms of acquisition of mcr-1 -bearing plasmid by Salmonella strains recovered from animals and food samples

scientific article published on 16 October 2017

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

scientific article

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

scientific article published on 27 October 2017

Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data.

scientific article published on 9 January 2018

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China

scientific article published on 26 February 2019

Emergence of an Empedobacter falsenii strain harbouring a tet(X)-variant-bearing novel plasmid conferring resistance to tigecycline

scientific article published on 01 March 2020

Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

scientific article

Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin

scientific article

Emerging high-level ciprofloxacin resistance and molecular basis of resistance in Salmonella enterica from humans, food and animals.

scientific article published on 2 May 2018

Engineering Clostridia Neurotoxins with elevated catalytic activity

scientific article

Engineering botulinum neurotoxin to extend therapeutic intervention.

scholarly article

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

scientific article published on 16 September 2020

Erratum to: Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data

scientific article published on 01 March 2019

Evolution and comparative genomics of pAQU-like conjugative plasmids in Vibrio species

scientific article published on 20 June 2017

Evolution and dissemination of OqxAB-like efflux pumps, an emerging quinolone resistance determinant among members of Enterobacteriaceae

scientific article published on 23 March 2015

Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of bla VIM-1-Bearing Plasmid

scientific article published on 23 August 2019

Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract

scientific article published on 09 July 2018

Expansion of Salmonella enterica Serovar Typhimurium ST34 Clone Carrying Multiple Resistance Determinants in China

scientific article published on 24 June 2013

Exploration of endogenous substrate cleavage by various forms of botulinum neurotoxins.

scientific article published on 22 April 2015

Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7.

scientific article published on 7 April 2015

First detection of a blaCTX-M-15-Carrying plasmid in Vibrio alginolyticus

scientific article published on 18 April 2018

First detection of conjugative plasmid-borne fosfomycin resistance gene fosA3 in Salmonella isolates of food origin

scientific article published on 15 December 2014

Functional Characterization of CTX-M-14 and CTX-M-15 β-Lactamases by In Vitro DNA Shuffling.

scientific article published on 2 October 2017

Functional and phylogenetic analysis of TetX variants to design a new classification system

scientific article published on 31 May 2022

Functional categorization of carbapenemase-mediated resistance by a combined genotyping and two-tiered Modified Hodge Test approach

scientific article

Genetic Characterization of Broad-Host-Range IncQ Plasmids Harboring blaVEB-18 in Vibrio Species

scientific article

Genetic Characterization of a blaVEB-2-Carrying Plasmid in Vibrio parahaemolyticus

scientific article published on 19 September 2016

Genetic Characterization of bla CTX-M-55 -Bearing Plasmids Harbored by Food-Borne Cephalosporin-Resistant Vibrio parahaemolyticus Strains in China

scientific article published on 18 June 2019

Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid

scientific article published on 8 May 2017

Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant.

scientific article published on 28 September 2016

Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China

scientific article published on 8 February 2018

Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction

scientific article published on 23 March 2015

High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China

scientific article published in September 2010

High virulence Proteus mirabilis strains cause acceleration of decay of fresh-cut fruits

scientific article published in 2023

HrpS Is a Global Regulator on Type III Secretion System (T3SS) and Non-T3SS Genes in Pseudomonas savastanoi pv. phaseolicola

scientific article published on 14 September 2018

IS26-mediated formation of a virulence and resistance plasmid in Salmonella Enteritidis

scientific article published in October 2017

Identification and Characterization of IncA/C Conjugative, bla NDM-1-Bearing Plasmid in Vibrio alginolyticus of Food Origin

scientific article published on 26 November 2018

Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7 , in Vibrio cholerae of seafood origin

article

Identification and characterization of a conjugative blaVIM-1-bearing plasmid in Vibrio alginolyticus of food origin

scientific article published on 01 July 2019

Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Strains

scientific article published on 13 April 2022

Identification of super-transmitters of SARS-CoV-2

scientific article published on 23 April 2020

IncFII Conjugative Plasmid-Mediated Transmission of blaNDM-1 Elements among Animal-Borne Escherichia coli Strains

scientific article

IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species.

scientific article published on 29 August 2016

IncI1 Plasmids Carrying Various blaCTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China.

scientific article published on 7 December 2015

Increased prevalence of strains from food carrying and -bearing plasmids that structurally resemble those of clinical strains, China, 2015 to 2017

article

Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations

scientific article

Increasing prevalence of hydrogen sulfide negative Salmonella in retail meats.

scientific article published on 30 April 2014

Insights into the Different Catalytic Activities of Clostridium Neurotoxins ⬇️

scientific article published on April 24, 2012

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2 H )-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1

scientific article published on 06 June 2018

Isolation of carbapenem-resistant Pseudomonas spp. from food

scientific article published on 27 April 2015

Klebsiella species: Taxonomy, hypervirulence and multidrug resistance

scientific article published in 2022

Light Chain of Botulinum Neurotoxin Serotype A: Structural Resolution of a Catalytic Intermediate†,‡

scientific article published on 01 July 2006

Mechanism of substrate recognition by botulinum neurotoxin serotype A.

scientific article published on 23 January 2007

Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5.

scientific article

Mechanisms of fluoroquinolone resistance in Vibrio parahaemolyticus

scientific article published on 07 June 2013

Metabolic Labeling of Pseudaminic Acid-Containing Glycans on Bacterial Surfaces

scientific article published on 03 October 2018

Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens

scientific article published on 10 March 2020

Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus

scientific article published in October 2013

Molecular characterization of qnrVC and their novel alleles in Vibrio spp. isolated from food products in China.

scientific article published on 16 April 2018

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii clinical isolates from the respiratory department of a tertiary care hospital in Henan, China

scientific article

Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase

scientific article

Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F.

scientific article

Multiple Pocket Recognition of SNAP25 by Botulinum Neurotoxin Serotype E

scientific article published in Journal of Biological Chemistry

Mutational Analysis of Quinolone Resistance Protein QnrVC7 Provides Novel Insights into the Structure-Activity Relationship of Qnr Proteins

scientific article published on 11 January 2016

Nanoporous membrane based impedance sensors to detect the enzymatic activity of botulinum neurotoxin A

scientific article published on 04 November 2013

Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China

scientific article

Over-Expression of ISAba1-Linked Intrinsic and Exogenously Acquired OXA Type Carbapenem-Hydrolyzing-Class D-ß-Lactamase-Encoding Genes Is Key Mechanism Underlying Carbapenem Resistance in Acinetobacter baumannii

scientific article published on 04 December 2019

PMQR genes oqxAB and aac(6')Ib-cr accelerate the development of fluoroquinolone resistance in Salmonella typhimurium

scientific article

Phenol-Soluble-Modulin-Inspired Amphipathic Peptides Have Bactericidal Activity against Multidrug-Resistant Bacteria

scientific article published on 30 July 2019

Plasmid-mediated ciprofloxacin, carbapenem and colistin resistance of a foodborne Escherichia coli isolate

scientific article published in 2022

Prevalence and Molecular Characterization of mcr-1-Positive Salmonella Strains Recovered from Clinical Specimens in China.

scientific article published on 13 February 2017

Prevalence and genetic characteristics of carbapenem-resistant Enterobacteriaceae strains in China.

scientific article

Prevalence and phenotypic characterization of carbapenem-resistant strains recovered from sputum and fecal samples of ICU patients in Zhejiang Province, China

article

Prevalence of Virulence Genes in Extended-Spectrum β-lactamases (ESBLs)-Producing Salmonella in Retail Raw Chicken in China

article

Rapid Detection of K1 Hypervirulent Klebsiella pneumoniae by MALDI-TOF MS.

scientific article published on 21 December 2015

Rapid and Sensitive Detection of Bacteria Response to Antibiotics Using Nanoporous Membrane and Graphene Quantum Dot (GQDs)-Based Electrochemical Biosensors

scientific article

Rapid resolution of multi-drug resistance bacterial genome harbouring mcr-1 and bla using MinION sequencing platform

Recombination of plasmids in a carbapenem-resistant NDM-5-producing clinical Escherichia coli isolate

scientific article published on 23 January 2018

Risk factors and clinical impact associated with infections caused by different types of carbapenem-resistant Klebsiella pneumoniae in China: A clinical study from 2014 to 2017

scientific article published in 2022

RpoN-Dependent Direct Regulation of Quorum Sensing and the Type VI Secretion System in Pseudomonas aeruginosa PAO1

scientific article published on 25 July 2018

Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism

scientific article published on 24 February 2020

Selective and suppressive effects of antibiotics on donor and recipient bacterial strains in gut microbiota determine transmission efficiency of blaNDM-1-bearing plasmids

scientific article published on 01 July 2019

Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes.

scientific article

Specific Amino Acid Substitutions in OXA-51-Type <i>β</i>-Lactamase Enhance Catalytic Activity to a Level Comparable to Carbapenemase OXA-23 and OXA-24/40

scientific article published on 19 April 2022

Structural Diversity, Fitness Cost, and Stability of a BlaNDM-1-Bearing Cointegrate Plasmid in Klebsiella pneumoniae and Escherichia coli

scientific article published in 2021

Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution

scientific article published on 21 November 2019

Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

scientific article published on 11 December 2021

Structure-based Design, Synthesis, and Biological Evaluation of Isatin Derivatives as Potential Glycosyltransferase Inhibitors

scientific article published on 14 August 2014

Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication ⬇️

scientific article

Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine

scientific article published in February 2018

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

scientific article published on 29 April 2017

Synthetic Hexadecapeptide Prevents Postharvest <i>Pectobacterium carotovorum</i> (<i>subsp. brasiliensis BC1</i>) Infection via Destabilizing Cell Envelope and Suppressing Biosynthesis of Arginine and Peptidoglycan

scientific article published in 2021

The Protective Effects of Salubrinal on the Cartilage and Subchondral Bone of the Temporomandibular Joint under Various Compressive Mechanical Stimulations

scientific article

The isolation of antibiotic-resistant salmonella from retail ground meats

scientific article published in October 2001

Total synthesis of teixobactin.

scientific article published on 3 August 2016

Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process

scientific article published on 14 July 2020

Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains

scientific article published on 12 August 2018

Unique substrate recognition by botulinum neurotoxins serotypes A and E.

scientific article

Unique substrate recognition mechanism of the botulinum neurotoxin D light chain

scientific article published on 19 August 2013

Widespread Dissemination of Carbapenem-Resistant Escherichia coli Sequence Type 167 Strains Harboring blaNDM-5 in Clinical Settings in China

scientific article published on 25 April 2016

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