Search filters

List of works by Christian Speck

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

scientific article

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.

scientific article

A top-down view on DNA replication and recombination from 9,000 feet above sea level

scientific article published on 27 April 2011

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

scientific article

ATP- and ADP-dnaA protein, a molecular switch in gene regulation.

scientific article

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

scientific article

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

scientific article

An integrated workflow for crosslinking mass spectrometry

Bacterial replication initiator DnaA. Rules for DnaA binding and roles of DnaA in origin unwinding and helicase loading

scientific article

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

scientific article

Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy

scientific article published in March 2012

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

scientific article published on 25 October 2017

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

scientific article published on 14 July 2013

Evolution of DNA replication origin specification and gene silencing mechanisms

scientific article published on 14 October 2020

Exceeding the limits - Cdc45 overexpression turns bad.

scientific article

From footprint to toeprint: a close-up of the DnaA box, the binding site for the bacterial initiator protein DnaA.

scientific article published on August 1997

From structure to mechanism-understanding initiation of DNA replication.

scientific article

Functional domains of DnaA proteins.

scientific article published in August 1999

Genetic organization of the Vibrio harveyi DnaA gene region and analysis of the function of the V. harveyi DnaA protein in Escherichia coli

scientific article

Helicase loading: how to build a MCM2-7 double-hexamer.

scientific article published on 14 March 2014

Identification of the chromosomal replication origin from Thermus thermophilus and its interaction with the replication initiator DnaA.

scientific article published in June 2000

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

scientific article

Opening the gate to DNA replication

scientific article published on January 2015

Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats

scientific article published on 9 June 2004

Replicating repetitive DNA

scientific article published on 01 May 2016

Seeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader

scientific article published on 21 August 2013

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

scientific article

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

scientific article published on 13 February 2017

Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein

scientific article published in May 1998

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

scientific article published on 15 July 2020

Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated

scientific article

The Escherichia coli SeqA protein binds specifically and co-operatively to two sites in hemimethylated and fully methylated oriC

scientific article published on 01 June 2000

The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat.

scientific article

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

scientific article published on 14 November 2013

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading

scientific article published on July 2013

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

scholarly article

The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.

scientific article

Paulina is supported by:

About Paulina

Help