Search filters

List of works by Satu Mustjoki

A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells

scientific article published on 22 April 2020

A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors

scientific article published on 27 January 2011

A novel class of somatic mutations in blood detected preferentially in CD8+ cells

scientific article published on 05 December 2016

A novel dasatinib-sensitive RCSD1-ABL1 fusion transcript in chemotherapy-refractory adult pre-B lymphoblastic leukemia with t(1;9)(q24;q34).

scientific article published on October 2009

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

scientific article published on 01 April 2019

ADA2 deficiency: clonal lymphoproliferation in a subset of patients

scientific article published on 29 January 2018

Abstract 1169: Somatic MED12 mutations in hematological malignancies

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

scientific article published on 15 February 2018

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

scientific article

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

scientific article

Acute lymphoblastic leukemia associated with RCSD1–ABL1 novel fusion gene has a distinct gene expression profile from BCR–ABL1 fusion

article

Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients

scientific article published on 08 February 2020

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

scientific article published on 19 April 2018

Appearance of bone marrow lymphocytosis predicts an optimal response to imatinib therapy in patients with chronic myeloid leukemia

scientific article published on 14 June 2007

Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia

scientific article published on 8 January 2016

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

scientific article

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.

scientific article published on 28 December 2017

Characterization of Bone Marrow Niche in Chronic Myeloid Leukemia Patients Identifies CXCL14 as a New Therapeutic Option

scientific article published in 2023

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

scientific article published on 09 November 2020

Characterization of polydactyly chondrocytes and their use in cartilage engineering

scientific article published on 12 March 2019

Chronic myeloid leukemia patients in prolonged remission following interferon-α monotherapy have distinct cytokine and oligoclonal lymphocyte profile

scientific article

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

scientific article

Clonal hematopoiesis in patients with rheumatoid arthritis

scholarly article by Paula Savola et al published 26 July 2018 in Blood Cancer Journal

Combination of pegylated IFN-α2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia

scientific article

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

scientific article published on 29 November 2016

Comparison of bone marrow high mitotic index metaphase fluorescence in situ hybridization to peripheral blood and bone marrow real time quantitative polymerase chain reaction on the International Scale for detecting residual disease in chronic myelo

scientific article

Corrections: Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

scientific article published on 23 October 2020

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

scientific article published on 20 January 2017

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models

scientific article published on 10 January 2017

Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia

scientific article published on 13 May 2008

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006).

scientific article

Dasatinib promotes Th1-type responses in granzyme B expressing T-cells

scientific article

Dasatinib reversibly disrupts endothelial vascular integrity by increasing non-muscle myosin II contractility in a ROCK-dependent manner

scientific article

Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes

scientific article published on 22 October 2013

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

scientific article

Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial.

scientific article

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.

scientific article published on 14 August 2017

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

scientific article published on 17 April 2013

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

scientific article published on 7 February 2018

Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease

scientific article published on 27 June 2019

Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia

scientific article published on 16 July 2013

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

scientific article

Drug-perturbation-based stratification of blood cancer

scientific article published on 11 December 2017

Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia.

scientific article

Enlarged memory T-cell pool and enhanced Th1-type responses in chronic myeloid leukemia patients who have successfully discontinued IFN-α monotherapy

scientific article published on 31 January 2014

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.

scientific article

Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

scientific article published on 7 February 2017

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.

scientific article published on 3 October 2016

IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia

scientific article published in 2022

IFNα induces prolonged remissions modeling curative immunologic responses in chronic myeloid leukemia

scientific article

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.

scientific article published on 12 September 2016

IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome

scientific article published on 12 June 2015

Imatinib and pegylated IFN-α2b discontinuation in first-line chronic myeloid leukemia patients following a major molecular response

scientific article published on 28 January 2014

Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL

scientific article published on 11 January 2019

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

scholarly article by Oscar Brück et al published 20 June 2018 in Leukemia

Immune cell phenotype and functional defects in Netherton syndrome

scientific article published on 26 November 2018

Immune control in chronic myeloid leukemia

scientific article published on 3 November 2017

Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival

scientific article published on 01 January 2020

Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line

scientific article published on 13 July 2019

Immunology and immunotherapy of chronic myeloid leukemia

scientific article published on March 2014

Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy

scientific article published on November 2010

Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)

scientific article

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

scientific article

Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia

scientific article published on 15 April 2009

Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia

scientific article

Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.

scientific article

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

scientific article published on 20 September 2013

Induction of sustained deep molecular response in a patient with chronic-phase T315I-mutated chronic myeloid leukemia with interferon-α monotherapy

scientific article published on 25 July 2013

Intrafamily and Interfamilial Phenotype Variation and Immature Immunity in Patients With Netherton Syndrome and Finnish SPINK5 Founder Mutation.

scientific article

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL

scientific article published on 21 November 2019

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV).

scientific article published on 28 August 2008

Killer-cell immunoglobulin-like receptor gene profile predicts good molecular response to dasatinib therapy in chronic myeloid leukemia.

scientific article

Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia

scientific article published on 17 June 2019

Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy

scientific article

Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia

scientific article published on 13 June 2017

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion

scientific article published on 11 April 2017

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion

scientific article published on 20 June 2017

Low or undetectable numbers of Philadelphia chromosome-positive leukemic stem cells (Ph(+)CD34(+)CD38(neg)) in chronic myeloid leukemia patients in complete cytogenetic remission after tyrosine kinase inhibitor therapy

scientific article published on 24 September 2009

Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity

scientific article published on 21 March 2016

Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS

scientific article published on 22 March 2021

Modelling of killer T-cell and cancer cell subpopulation dynamics under immuno- and chemotherapies

scientific article published on 27 December 2019

Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy.

scientific article published on 22 April 2010

Morphology antibody chromosome technique for determining phenotype and genetic status of the same cell

scientific article published on July 2012

Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia

scientific article published on 01 February 2020

NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib

scientific article published on 10 July 2017

Non-Ph variants in CML: guilty drivers?

scientific article published on 01 August 2018

Novel TBL1XR1, EPHA7 and SLFN12 mutations in a Sezary syndrome patient discovered by whole exome sequencing

scientific article published in May 2014

Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

scientific article published on 05 December 2019

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

scientific article published on 27 February 2014

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

scientific article published on May 2015

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

scientific article published on 06 December 2013

Oligoarray comparative genomic hybridization in polycythemia vera and essential thrombocythemia

scientific article published on 01 July 2008

PD-L1 tumor-associated macrophages and PD-1 tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma

scholarly article by Marjukka Pollari et al published November 2018 in Haematologica

Patient-customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

scientific article published on 26 February 2018

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

scientific article published in Nature Communications

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

scientific article published on 11 July 2019

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients

scientific article

Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli

scientific article published on 27 September 2016

Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy

scientific article published on 23 January 2020

Poor cytokine-induced phosphorylation in chronic myeloid leukemia patients at diagnosis is effectively reversed by tyrosine kinase inhibitor therapy.

scientific article published on 12 October 2010

Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma

scientific article published on 04 April 2020

Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

scientific article published on 20 February 2019

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

scientific article published on 11 August 2020

Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy.

scientific article

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia

scientific article published on 7 November 2016

Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

scientific article published on 25 February 2020

STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK- ALCL

scientific article published on 16 March 2020

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

scientific article

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

scientific article published on 2 August 2012

Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

scientific article published on 02 May 2016

Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells

scientific article published on 01 April 2021

Sex bias in MHC I-associated shaping of the adaptive immune system.

scientific article published on 12 February 2018

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib

scientific article published on 18 May 2017

Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML.

scientific article

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

scientific article

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

scientific article

Somatic STAT3 mutations in large granular lymphocytic leukemia ⬇️

scientific article

Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia

scientific article published on 7 December 2017

Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease

scientific article published on 07 May 2020

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.

scientific article

Spermidine/spermine N1-acetyltransferase activity associates with white blood cell count in myeloid leukemias

scientific article published on 04 March 2014

Subclonal STAT3 mutations solidify clonal dominance

article published in 2019

Suboptimal responses in chronic myeloid leukemia: milestones and mechanisms

scientific article published on February 2009

T and NK cell abundance defines two distinct subgroups of renal cell carcinoma

scientific article published on 04 January 2022

T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma

scholarly article by Suvi-Katri Leivonen et al published February 2019 in Haematologica

Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia

scientific article published on 01 July 2018

Terminal deletion of 11q with significant late-onset combined immune deficiency

scientific article

The SCLtTAxBCR-ABL transgenic mouse model closely reflects the differential effects of dasatinib on normal and malignant hematopoiesis in chronic phase-CML patients

scientific article

The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia

scientific article

The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses

scientific article published on 11 March 2015

The use of multiplex platforms for absolute and relative protein quantification of clinical material

Therapy de-escalation before stopping in chronic myeloid leukaemia

scientific article published on 11 June 2019

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

scientific article published on 24 January 2019

Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia.

scientific article published on 23 March 2017

Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations

scientific article published on 11 February 2014

VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells

scientific article published on 15 August 2002

Paulina is supported by:

About Paulina

Help