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List of works by Carmen Guerra

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

scientific article

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

scientific article

Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation

scientific article

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

scientific article published on 01 March 2007

Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells

scientific article

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

scientific article published on 02 February 2017

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

scientific article published on 08 April 2019

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

scientific article published on 30 May 2010

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

scientific article published on September 2012

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity ⬇️

scientific article published on July 15, 1998

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

scientific article published on 27 November 2011

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation

scientific article

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

scientific article

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

scientific article published on 01 May 2018

Germline expression of H-Ras(G12V) causes neurological deficits associated to Costello syndrome

scientific article published on 22 September 2008

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

scientific article published on 21 November 2016

IGF-I induces the uncoupling protein gene expression in fetal rat brown adipocyte primary cultures: role of C/EBP transcription factors.

scientific article

K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.

scientific article

K-RasV14I recapitulates Noonan syndrome in mice

scientific article

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

scholarly article

Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression

scientific article published on 21 September 2015

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

scientific article published on 28 April 2017

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

scientific journal article

Modeling RASopathies with Genetically Modified Mouse Models.

scientific article published on January 2017

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice

scientific article published on 12 August 2014

Noonan syndrome: lessons learned from genetically modified mouse models

scientific article published on 09 August 2017

Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis

scientific article published on 21 June 2019

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

scientific article published on June 2011

Parp-1genetic ablation inEla-mycmice unveils novel roles for Parp-1 in pancreatic cancer

scientific article published on 04 August 2014

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

scientific article published in January 2010

Reply: 'Comments on Stromal disrupting effects of nab-paclitaxel in pancreatic cancer'.

scientific article published on 18 March 2014

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

scientific article published on 19 January 2018

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.

scientific article published on 3 April 2018

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice

scientific article

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

scientific article

The impact of the genetic background in the Noonan syndrome phenotype induced by K-Ras(V14I).

scientific article published on 22 May 2015

Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its mRNA in Fetal Rat Brown Adipocyte Primary Cultures

scientific article published in Journal of Biological Chemistry

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression

article

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression

scientific article published on 01 March 1994

Tumour biology: senescence in premalignant tumours

scientific article published on August 2005

Upregulation of miR-21 by Ras in vivo and its role in tumor growth.

scientific article published on 18 October 2010

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

scientific article

What we have learned about pancreatic cancer from mouse models.

scientific article published on 08 March 2012

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

scientific article

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

scientific article published on 29 April 2007

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