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List of works by Tom W Claydon

4-aminopyridine prevents the conformational changes associated with p/c-type inactivation in shaker channels

scientific article published on 02 October 2006

A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels

scientific article published on 18 August 2005

An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.

scientific article published on 31 August 2007

Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4.

scientific article

Block by internal Mg2+ causes voltage-dependent inactivation of Kv1.5.

scientific article published on 11 August 2006

Correction

External protons destabilize the activated voltage sensor in hERG channels.

scientific article published on 21 December 2013

Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5.

scientific article published on November 2011

Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation

scientific article published on 07 December 2018

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

scientific article published on September 2013

Inhibition of the K+ channel kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery from N-type inactivation

scientific article published in July 2000

Ion channel model reduction using manifold boundaries

scientific article published in 2022

KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.

scientific article published on 20 December 2005

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

scientific article published on 27 June 2017

Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel

scientific article published on 22 September 2003

Molecular determinants of U-type inactivation in Kv2.1 channels

scientific article published on August 2011

Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels

scientific article

NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

scientific article

Photothermal release of small molecules from gold nanoparticles in live cells ⬇️

scientific article published on November 16, 2011

Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residues

scientific article published on 8 June 2016

Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.

scientific article

Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis

scientific article published on 18 April 2012

Proton sensors in the pore domain of the cardiac voltage-gated sodium channel

scientific article published on 2 January 2013

Rapid outer pore movements after opening in a KV1 potassium channel are revealed by TMRM fluorescence from the S3-S4 linker, and modulated by extracellular potassium

scientific article

Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization

scientific article published on 10 January 2014

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart

scientific article published on 29 September 2006

SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5.

scientific article published on 6 September 2006

Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker

scientific article published in January 2017

The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel ⬇️

scientific article published on October 2, 2003

The Zebrafish Heart as a Model of Mammalian Cardiac Function

scientific article

Two pore residues mediate acidosis-induced enhancement of C-type inactivation of the Kv1.4 K(+) channel

scientific article published in October 2002

Voltage clamp fluorimetry reveals a novel outer pore instability in a mammalian voltage-gated potassium channel.

scientific article

Voltage clamp fluorimetry studies of mammalian voltage-gated K(+) channel gating.

scientific article published on November 2007

Voltage-Dependent Gating of hERG Potassium Channels ⬇️

scientific article published on 08 May 2012

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