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List of works by Paul H. Weinreb

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

scientific article published on 16 November 2020

Aggregated SOD1 causes selective death of cultured human motor neurons

scientific article published in Scientific Reports

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

scientific article published on January 2007

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

scientific article

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

scientific article published on 01 January 2008

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

scientific article published on 25 October 2010

Blockade of Nogo receptor ligands promotes functional regeneration of sensory axons after dorsal root crush.

scientific article

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

scientific article published on 01 February 1998

Characterization of integrin beta6 and thrombospondin-1 double-null mice

scientific journal article

Characterization of trisulfide modification in antibodies

scientific article published on 18 January 2010

Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice

scientific article

Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment

scientific article (publication date: 11 April 2003)

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

scientific article published on November 2006

Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma.

scientific article

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.

scientific article

Effect of wound type on Smad 2 and 4 translocation

scientific article

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

scientific article published on April 2001

Fibronectin-guided migration of carcinoma collectives

scientific article published on 19 January 2017

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes

scientific article published on 11 February 2004

Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice.

scientific article

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

article

High expression of integrin β6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers.

scientific article published on 17 May 2016

Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin

scientific journal article

Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.

scientific article

Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation

scientific article

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis

scientific article

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

scientific article published on 07 February 2014

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

scientific article published on 6 January 2017

Integrin alphavbeta6 and mediators of extracellular matrix deposition are up-regulated in experimental biliary atresia.

scientific article published on 20 June 2008

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.

scientific article published on 08 October 2015

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

scientific article published on 14 February 2008

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

scientific article published on 28 September 2020

Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β

scientific article

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

scientific article published on 15 January 2009

Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

scientific article published on January 2009

Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo

scientific article published on 01 May 2003

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.

scientific article published on 04 June 2009

Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival

scientific article published on 01 July 2007

Overexpression of the alphavbeta6 integrin in endometrial cancer

scientific article published on 01 December 2008

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation

scientific article published on 04 October 2007

Post-translational modification of polyketide and nonribosomal peptide synthases ⬇️

scientific article published on October 1, 1997

Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.

scientific article published on March 2007

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression

scientific article published on 9 February 2016

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

scientific article published on September 1, 2010

Role of ITGAE in the development of autoimmune diabetes in non-obese diabetic mice

scientific article published on 18 December 2014

Stoichiometry and Specificity of In Vitro Phosphopantetheinylation and Aminoacylation of the Valine-Activating Module of Surfactin Synthetase ⬇️

scientific article published on February 10, 1998

Stromal features are predictive of disease mortality in oral cancer patients

scientific article published on 05 January 2011

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

scientific article published on 23 April 2018

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

scientific article published on 29 April 2014

Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1.

scientific article published on 16 April 2015

The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle.

scientific article published on October 2005

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

scientific article (publication date: 31 August 2016)

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

scientific article

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

scientific article published on 01 March 1995

Therapeutic targeting of integrin αvβ6 in breast cancer

scientific article

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

scientific article published in April 2017

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis

scientific article

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

scientific article

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor

scientific article

αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease

scientific article

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