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List of works by Paolo Mignatti

A quantitative in vitro model of smooth muscle cell migration through the arterial wall using the human amniotic membrane

scientific article published on 03 April 2003

Activation of mitogen-activated protein kinases during preparation of vein grafts and modulation by a synthetic inhibitor.

scientific article published in September 2003

Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis

scientific article

Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts

scientific article published on 22 November 2005

Arrested Development: Infantile Hemangioma and the Stem Cell Teratogenic Hypothesis

scientific article published on 18 May 2017

Basic fibroblast growth factor (FGF-2): the high molecular weight forms come of age.

scientific article published on April 2007

Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner

scientific article published on December 1991

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex

scientific article published on April 1992

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity ⬇️

scientific article published on August 1, 1992

Biology and biochemistry of proteinases in tumor invasion.

scientific article published on January 1993

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants.

scientific article

Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosis

scientific article published on 09 March 2009

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms.

scientific article

Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.

scientific article

Expression of Von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: a potential method for objective assessment of tumor angiogenesis

scientific article published on 01 January 2000

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor ⬇️

scientific article published on June 1, 1991

Growth factor control of extracellular proteolysis ⬇️

scientific article published on December 2, 1990

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

scientific article

Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression

scientific article published on 01 April 2002

Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2-/- microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2)

scientific article published on 01 December 2003

Infantile Hemangioma Originates From A Dysregulated But Not Fully Transformed Multipotent Stem Cell.

scientific article

Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study.

scientific article published on 27 July 2016

Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3.

scientific article published on March 2009

Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice

scientific article published on 01 July 1998

Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells

scientific article published on 01 April 2002

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

article published in 2018

Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2

scientific article published on 11 November 2005

Mechanical endothelial damage results in basic fibroblast growth factor-mediated activation of extracellular signal-regulated kinases

scientific article published on 01 August 1999

Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

scientific article published on 01 June 1993

Mechanisms of c-reactive protein up-regulation in arterialized vein grafts.

scientific article

Membrane-Type 1 Matrix Metalloproteinase Downregulates Fibroblast Growth Factor-2 Binding to the Cell Surface and Intracellular Signaling.

scientific article

Mitral valve prolapse is associated with altered extracellular matrix gene expression patterns.

scientific article published on 05 April 2016

Modulation of matrix metalloproteinase activity in human saphenous vein grafts using adenovirus-mediated gene transfer

scientific article

Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase-dependent tumor cell invasion

scientific article published on 01 February 2000

New observations on the intracellular localization and release of bFGF.

scientific article published on January 1991

Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology.

scientific article

PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus

scientific article published in August 2005

Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism

scientific article published on 01 August 2002

Plasminogen activators and angiogenesis.

scientific article published on January 1996

Plasminogen activators, activation inhibitors and alpha 2-macroglobulin produced by cultured normal and malignant human cells

scientific article published on 01 May 1984

Proteases and extracellular environment

scientific article published on 01 February 2005

Purification and biological activities of an angiogenesis factor from human placenta

scientific article published on 01 July 1986

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism? ⬇️

scientific article published on November 1, 1991

Roles of MT1-MMP in the regulation of cell surface proteolysis

scientific article published on 01 June 1999

Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells

scientific article published on 30 September 2003

Soluble factor(s) released from neutrophils activates endothelial cell matrix metalloproteinase-2.

scientific article published in April 1998

TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling.

scientific article published on December 2008

TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.

scientific article published on 20 April 2012

TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis

scientific article published on 2 September 2015

The role of proteases in matrix breakdown during cellular invasion

scientific article published on 01 October 1989

Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2): a novel mechanism for the control of FGF-2 and thrombin activity

scientific article published on 29 October 2007

Topical mitogen-activated protein kinases inhibition reduces intimal hyperplasia in arterialized vein grafts.

scientific article

Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis

scientific article published on May 2009

Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase

scientific article published on 01 August 2002

Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF)

scientific article published on 01 November 2002

Tumor cell-conditioned medium stimulates expression of the urokinase receptor in vascular endothelial cells

scientific article published on 01 November 1996

Tumor cells secrete an angiogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells.

scientific article

Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade

scientific article published on 01 November 1986

Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1.

scientific article published on 2 November 2015

Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.

scientific article published in July 1997

Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells

scientific article published on 01 April 1995

Vascular injury and modulation of MAPKs: a targeted approach to therapy of restenosis.

scientific article published on 15 March 2007

Vein graft arterialization causes differential activation of mitogen-activated protein kinases.

scientific article published in May 2004

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