Search filters

List of works by Floyd E Romesberg

A Method for the Exponential Synthesis of RNA: Introducing the Polymerase Chain Transcription (PCT) Reaction.

scientific article

A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.

scientific article published on 17 January 2018

A broader take on DNA

scientific article published in Nature

A high-resolution probe of protein folding

scientific article published in March 2004

A putative cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus.

scientific article published on 9 March 2015

A semi-synthetic organism with an expanded genetic alphabet

scientific article

A semisynthetic organism engineered for the stable expansion of the genetic alphabet.

scientific article

Amplify this! DNA and RNA get a third base pair

scientific article published on 01 September 2006

An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus

scientific article

Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations

scientific article

Carbon-deuterium bonds as non-perturbative infrared probes of protein dynamics, electrostatics, heterogeneity, and folding

scientific article published on 01 January 2014

Carbon-deuterium bonds as probes of dihydrofolate reductase

scientific article published on 16 April 2008

Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes

scientific article

Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet

scientific article

Chemical frustration in the protein folding landscape: grand canonical ensemble simulations of cytochrome c.

scientific article

Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation.

scientific article published on September 2007

Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid.

scientific article published on 26 May 2017

Cyano groups as probes of protein microenvironments and dynamics

scientific article published on 20 July 2011

Determinants of unnatural nucleobase stability and polymerase recognition

scientific article

Development of a universal nucleobase and modified nucleobases for expanding the genetic code.

scientific article published in November 2002

Directed evolution of novel polymerases.

scientific article

Directed polymerase evolution.

scientific article

Discovery of novel antibacterials.

scientific article

Efforts toward broadening the spectrum of arylomycin antibiotic activity.

scientific article published on 14 August 2013

Eight-Letter DNA

scientific article published on 22 May 2019

Enzymatic Synthesis, Amplification, and Application of DNA with a Functionalized Backbone

scientific article published on 15 September 2017

Enzymatic phosphorylation of unnatural nucleosides

scientific article published in December 2002

Evolved polymerases facilitate selection of fully 2'-OMe-modified aptamers

scientific article published on 16 October 2017

Expansion of the Genetic Alphabet: A Chemist's Approach to Synthetic Biology.

scientific article published on 2 December 2017

Exploring the energy landscape of antibody-antigen complexes: protein dynamics, flexibility, and molecular recognition

scientific article published on 13 June 2008

IR probes of protein microenvironments: utility and potential for perturbation

scientific article published on 12 February 2014

Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.

scientific article published on 8 April 2008

In Vivo Structure-Activity Relationships and Optimization of an Unnatural Base Pair for Replication in a Semi-Synthetic Organism.

scientific article published on 10 August 2017

Inhibition of Protein Secretion in Escherichia coli and Sub-MIC Effects of Arylomycin Antibiotics

scientific article published on 29 January 2019

Initial Analysis of the Arylomycin D Antibiotics

scientific article published on 02 July 2020

Major Groove Substituents and Polymerase Recognition of a Class of Predominantly Hydrophobic Unnatural Base Pairs ⬇️

scientific article published on December 21, 2011

Major groove derivatization of an unnatural base pair.

scientific article

Multidisciplinary experimental approaches to characterizing biomolecular dynamics.

scientific article

Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair

scientific article published on 27 January 2020

Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications

scientific article

New codons for efficient production of unnatural proteins in a semisynthetic organism

scientific article published on 06 April 2020

Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence

scientific article

Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism

scientific article published on 26 June 2019

Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.

scientific article published on 15 March 2018

Optimization of interstrand hydrophobic packing interactions within unnatural DNA base pairs

scientific article published in November 2004

Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication

scientific article

Optimization of unnatural base pair packing for polymerase recognition.

scientific article published on May 2006

Origins of Yersinia pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase

scientific article published on 20 April 2015

Phosphatases, DNA damage checkpoints and checkpoint deactivation

scientific article published on 20 September 2007

Polymerase Chain Transcription: Exponential Synthesis of RNA and Modified RNA.

scientific article published on 17 July 2017

Polymerase evolution: efforts toward expansion of the genetic code

scientific article published on September 2005

Polymerase recognition and stability of fluoro-substituted pyridone nucleobase analogues

scientific article published on 01 September 2007

Preliminary characterization of light harvesting in E. coli DNA photolyase

scientific article

Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet

scientific article published on 12 November 2018

Progress toward Eukaryotic Semisynthetic Organisms: Translation of Unnatural Codons

scientific article published on 16 December 2019

Protein dynamics and the diversity of an antibody response.

scientific article

Reply to Hettinger: Hydrophobic unnatural base pairs and the expansion of the genetic alphabet

scientific article

Reprograming the Replisome of a Semisynthetic Organism for the Expansion of the Genetic Alphabet

scientific article published on 8 January 2018

SOS regulatory elements are essential for UPEC pathogenesis

scientific article published on 11 May 2010

Scalable Access to Arylomycins via C-H Functionalization Logic.

scientific article

Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties.

scientific article published on 20 February 2017

Selection of Aptamers with Large Hydrophobic 2'-Substituents

scientific article published on 21 January 2020

Semisynthetic Organisms with Expanded Genetic Codes

scientific article published on 06 April 2018

Several novel approaches to developing therapeutics that target both bacterial and human proteins

scientific article published on 14 August 2008

Side effects may include evolution

scientific article published on 01 August 2006

Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases This work was supported by the National Institutes of Health (GM 60005 to F.E.R.) and the Skaggs Institute for Chemical Biology (F.E.R. and P.G.S.). A.K.O. thank

scientific article published on 01 August 2000

Structure and Dynamics of Stacking Interactions in an Antibody Binding Site

scientific article published on 19 June 2019

Synthesis and biological characterization of arylomycin B antibiotics

scientific article

Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.

scientific article

Synthetic Biology Parts for the Storage of Increased Genetic Information in Cells

scientific article

Tautomerization dynamics of a model base pair in DNA.

scientific article published in May 2001

The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation.

scientific article published on 10 June 2009

The expanded genetic alphabet

scientific article published on 25 August 2015

The folding energy landscape and free energy excitations of cytochrome c

scientific article

The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.

scientific article

Topological Evidence of Previously Overlooked Ni+1-H···Ni H-Bonds and Their Contribution to Protein Structure and Stability

scientific article published on 20 December 2017

Transcription and Reverse Transcription of an Expanded Genetic Alphabet In Vitro and in a Semisynthetic Organism

scientific article published on 29 October 2020

Transcription of an expanded genetic alphabet.

scientific article published on April 2009

Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II

scientific article published on 17 June 2021

Transparent Window Vibrational Probes for the Characterization of Proteins With High Structural and Temporal Resolution

scientific article published on 20 January 2017

Unnatural substrate repertoire of A, B, and X family DNA polymerases.

scientific article

Paulina is supported by:

About Paulina

Help