List of works by Linda L Demer

A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.

scientific article

A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells".

scientific article published on 25 October 2007

A skeleton in the atherosclerosis closet

scientific article published on 01 October 1995

Active serum vitamin D levels are inversely correlated with coronary calcification

scientific article (publication date: 16 September 1997)

Adipose rex: fat and fats that rule differentiation

scientific article published on 01 February 2002

Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?

scientific article published on October 1997

Assessment of coronary artery disease severity by positron emission tomography. Comparison with quantitative arteriography in 193 patients

scientific article published on 01 April 1989

Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells

scientific article (publication date: December 1999)

Atherogenic high-fat diet reduces bone mineralization in mice

scientific article published in January 2001

Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.

scientific article

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics

scientific article

Bone morphogenetic protein expression in human atherosclerotic lesions.

scientific article published on April 1993

Boning up (or down) on statins

scientific article published on 01 October 2001

COMP-lex Mechanics: Matricrine Signaling.

scientific article published on July 2016

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

scientific article

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

scientific article published in October 2011

Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol

scientific article published on 01 April 1997

Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification

scientific article

Changes in myocardial perfusion reserve after PTCA: noninvasive assessment with positron tomography

scientific article published on 01 August 1987

Conflicting forces of warfarin and matrix gla protein in the artery wall

scientific article published in January 2015

Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation

scientific article published on 11 April 2019

Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.

scientific article published on May 1996

Determinants of instantaneous pressure in canine left ventricle. Time and volume specification.

scientific article published in February 1980

Development of Ni-4 wt.% Si thermoseeds for hyperthermia cancer treatment ⬇️

scientific article published on April 1, 1988

Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice.

scientific article published in July 1991

Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells.

scientific article

Effect of calcification and formalin fixation on in vitro distensibility of human femoral arteries

scientific article published in February 1993

Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation.

scientific article

Effect of inflation pressures on coronary angioplasty balloons

scientific article published on 01 January 1986

Effects of bioactive lipids and lipoproteins on bone.

scientific article published on 30 October 2013

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.

scientific article published on 16 February 2018

Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt).

scientific article published in May 2002

Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers.

scientific article

Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography.

scientific article

Exosomes: nanosized cellular messages.

scientific article published on April 2015

FGF23 protein expression in coronary arteries is associated with impaired kidney function.

scientific article

Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory

scientific article published on 01 December 1998

Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells.

scientific article published on 11 July 2012

Genetic determination of cartilaginous metaplasia in mouse aorta.

scientific article published in December 1995

HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells.

scientific article

High intensity ultrasound increases distensibility of calcific atherosclerotic arteries

scientific article published on 01 November 1991

High-density lipoprotein regulates calcification of vascular cells.

scientific article published in October 2002

Hyperlipidemia impairs osteoanabolic effects of PTH.

scientific article

Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo

scientific article published on 11 December 2003

Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro

scientific article

In vivo assessment of vascular dilatation during percutaneous transluminal coronary angioplasty

scientific article published on 01 November 1987

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

scientific article published on 5 July 2016

Inflammatory, metabolic, and genetic mechanisms of vascular calcification.

scientific article published on April 2014

Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.

scientific article published on October 1999

Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways

scientific article published on 3 February 2005

Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease

scientific article published on 03 July 2019

Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics.

scientific article

Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.

scientific article published in April 1997

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

scientific article published on 23 November 2018

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

scientific article published on 13 February 2020

Mechanical response of a calcified plaque model to fluid shear force

scientific article published on 28 September 2006

Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability

scientific article published on 19 June 2009

Mechanism of calcification in atherosclerosis

scientific article

Mechanisms linking osteoporosis with cardiovascular calcification.

scientific article published on July 2009

Mesenchymal stem cells and the artery wall.

scientific article published in October 2004

Metabolic and functional recovery of ischemic human myocardium after coronary angioplasty

scientific article published on 01 October 1991

Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses.

scientific article published in February 2004

Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture

scientific article published on 4 September 2003

Mineralocorticoid receptor activation promotes vascular cell calcification

scientific article published on 18 January 2007

Monocyte/macrophage regulation of vascular calcification in vitro

scientific article

Multilineage potential of cells from the artery wall.

scientific article published on 27 October 2003

Multiscale light-sheet for rapid imaging of cardiopulmonary system

scientific article published on 23 August 2018

N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways.

scientific article published on 2 March 2006

Nanoscale architecture in atherosclerotic calcification

scientific article published on November 2008

Noninvasive assessment of coronary collaterals in man by PET perfusion imaging

scientific article published on 01 March 1990

Novel mechanisms in accelerated vascular calcification in renal disease patients.

scientific article

Osteopontin. Between a rock and a hard plaque

scientific article published on 01 February 1999

Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.

scientific article published on 02 January 2008

Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship

scientific article published on February 2016

Oxidative stress modulates osteoblastic differentiation of vascular and bone cells

scientific article

Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss

scientific article

PKA-induced Receptor Activator of NF-κB Ligand (RANKL) Expression in Vascular Cells Mediates Osteoclastogenesis but Not Matrix Calcification ⬇️

scientific article published on July 27, 2010

Passive biaxial mechanical properties of isolated canine myocardium

scientific article published on 01 June 1983

Pathogenesis of atherosclerosis

scientific article published in September 1995

Pattern formation by vascular mesenchymal cells.

scientific article

Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts

scientific article published on 01 April 2000

Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification

scientific article published on 23 July 2008

Physician-scientists as missing persons. Association of Subspecialty Professors

scientific article published on 01 December 1995

Pitting Phosphate Transport Inhibitors Against Vascular Calcification

scientific article published on 14 April 2006

Placental calcification: a metastatic process?

scientific article published in July 2001

Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification.

scientific article published on 10 April 2015

Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells

scientific article published in November 2001

Recent advances in multifactorial regulation of vascular calcification.

scientific article

Regulation of RANKL-induced osteoclastic differentiation by vascular cells

scientific article published in August 2005

Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids

scientific article

Regulation of vascular calcification in atherosclerosis

scientific article published on 01 January 2001

Regulatory mechanisms in vascular calcification

scientific article published in September 2010

Regulatory mechanisms in vascular calcification.

scientific article

Reply: Evolutionary approach sheds light on the significance of vascular calcification.

scientific article

Return to Ectopia

scientific article published in July 2005

Rigor and Reproducibility in Analysis of Vascular Calcification

scientific article published in April 2017

Role of Molecular Regulation in Vascular Calcification ⬇️

scientific article published on January 1, 1996

Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification.

scientific article published on November 2006

Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells

scientific article published in November 2002

Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts.

scientific article published on January 2014

Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages.

scientific article

Serotonin receptor type 2B activation augments TNF-α-induced matrix mineralization in murine valvular interstitial cells

scientific article published on 09 September 2020

Skeleton key to vascular disease**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology

scientific article published in November 2004

Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation

scientific article published on 12 July 2018

Steroid Hormone Vitamin D: Implications for Cardiovascular Disease

scientific article published on 01 May 2018

Systems biology of vascular calcification

scientific article

T0901317, an LXR agonist, augments PKA-induced vascular cell calcification

scientific article published on 25 March 2009

TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.

scientific article

The Autism Spectrum: Human Rights Perspectives

scientific article published on 01 April 2018

The atherosclerosis-calcification link?

scientific article

The bone-vascular axis in chronic kidney disease.

scientific article

The leading edge of vascular calcification

scientific article published on 3 December 2014

The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification

scientific article

Thematic series on the pathobiology of vascular calcification: an introduction.

scientific article published on May 2011

Training the physician-scientist: views from program directors and aspiring young investigators

scientific article published on 06 December 2018

Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway

scientific article published on 01 November 2000

Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.

scientific article published on 8 February 2016

Vascular calcification

scientific article published on 01 October 2007

Vascular calcification and its relation to bone calcification: possible underlying mechanisms.

scientific article

Vascular calcification: pathobiology of a multifaceted disease

scientific article

Vitamin D and osteogenic differentiation in the artery wall

scientific article

cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.

scientific article published in March 1998

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