List of works - Stan B. Floresco

A role for neurogenesis in probabilistic reward learning

scientific article published on 07 May 2020

Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning

scientific article

Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making ⬇️

scientific article published on May 9, 2012

Acute stress impairs set-shifting but not reversal learning

scientific article published on 10 June 2013

Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.

scientific article

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

scientific article published in September 2003

Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists

scientific article published on 3 June 2006

Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder

scientific article

Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions

scientific article published on 10 April 2019

Alterations in time-place learning induced by lesions to the rat medial prefrontal cortex

scientific article published in August 2002

Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine

scientific article published on 06 November 2019

Androgen Regulation of the Mesocorticolimbic System and Executive Function.

scientific article published on 5 June 2018

Association Basolateral amygdala stimulation evokes glutamate receptor‐dependent dopamine efflux in the nucleus accumbens of the anaesthetized rat ⬇️

scientific article published on April 1, 1998

Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex

scientific article

Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

scientific article published on 8 March 2011

Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex

scientific article published on March 2014

Chronic methamphetamine self-administration alters cognitive flexibility in male rats.

scientific article published on 2 April 2016

Contributions of basolateral amygdala and nucleus accumbens subregions to mediating motivational conflict during punished reward-seeking

scientific article published on 24 February 2017

Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making

scientific article published in March 2011

Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues

scientific article published on 29 April 2010

Cooperative and dissociable involvement of the nucleus accumbens core and shell in the promotion and inhibition of actions during active and inhibitory avoidance

scientific article published on 22 May 2018

Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation

scientific article published on 15 June 2019

D-Cycloserine Facilitates Reversal in an Animal Model of Post-traumatic Stress Disorder

scientific article published on 23 March 2018

D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat.

scientific article

DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting

scientific article published on 22 February 2019

Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.

scientific article published in November 2016

Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia

scientific article published on 3 August 2005

Differential contributions of nucleus accumbens subregions to cue-guided risk/reward decision making and implementation of conditional rules.

scientific article published on 18 January 2018

Differential effects of corticotropin-releasing factor and acute stress on different forms of risk/reward decision-making

scientific article published on 17 January 2020

Differential effects of dopaminergic manipulations on risky choice

scientific article published on 22 May 2010

Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning

scientific article published on 28 November 2007

Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information

scientific article

Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell

scientific article published in April 2010

Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats ⬇️

scientific article published on December 1, 1997

Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure

scientific article published on 21 March 2009

Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making.

scientific article published in June 2011

Dissociable roles for the nucleus accumbens core and shell in regulating set shifting.

scientific article published in March 2006

Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making

scientific article published on 25 October 2019

Dopamine D1 and NMDA receptors mediate potentiation of basolateral amygdala-evoked firing of nucleus accumbens neurons.

scientific article published in August 2001

Dopamine Neurons, Input Integration, and Reward Prediction Errors: E Pluribus Unum

scientific article published in September 2016

Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks.

scientific article published on 20 October 2014

Dopaminergic circuitry and risk/reward decision making: implications for schizophrenia

scientific article published on 17 November 2014

Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway

scientific journal article

Dopaminergic regulation of limbic-striatal interplay.

scientific article

Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making

scientific article

Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats

scientific article published on 28 August 2018

Electrophysiological interactions between striatal glutamatergic and dopaminergic systems

scientific article published on November 2003

Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.

scientific article published on 26 July 2011

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex

scientific article published in December 1995

Fundamental contribution by the basolateral amygdala to different forms of decision making.

scientific article published in April 2009

Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area

scientific article (publication date: May 2003)

Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.

scientific article

High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory

scientific article published in November 2001

Hyperlocomotion and increased dopamine efflux in the rat nucleus accumbens evoked by electrical stimulation of the ventral subiculum: role of ionotropic glutamate and dopamine D 1 receptors

scientific article published on 01 August 2000

Involvement of the ventral pallidum in working memory tasks with or without a delay.

scientific article

Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task.

scientific article published on January 2004

Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research

scientific article published on 23 April 2012

Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection.

scientific article published in April 2001

Modulation of risk/reward decision making by dopaminergic transmission within the basolateral amygdala.

scientific article

Multifaceted Contributions by Different Regions of the Orbitofrontal and Medial Prefrontal Cortex to Probabilistic Reversal Learning

scientific article published in February 2016

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.

scientific article published on 10 September 2011

Neural circuits subserving behavioral flexibility and their relevance to schizophrenia.

scientific article published on 06 December 2008

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models.

scientific article published on 11 June 2015

Neuronal Gonadotrophin-Releasing Hormone (GnRH) and Astrocytic Gonadotrophin Inhibitory Hormone (GnIH) Immunoreactivity in the Adult Rat Hippocampus.

scientific article published on 10 August 2015

Noradrenaline and dopamine: sharing the Workload

scientific article published on 14 July 2015

Noradrenergic modulation of risk/reward decision making

scientific article

Operant procedures for assessing behavioral flexibility in rats.

scientific article

Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior.

scientific article published on 9 April 2008

Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making

scientific article published on 01 November 2018

Overriding phasic dopamine signals redirects action selection during risk/reward decision making

scientific article

Persistent cognitive and morphological alterations induced by repeated exposure of adolescent rats to the abused inhalant toluene

scientific article

Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

scientific article

Perturbations in reward-related decision-making induced by reduced prefrontal cortical GABA transmission: Relevance for psychiatric disorders

scientific article published on 8 October 2015

Pharmacological enhancement of memory and executive functioning in laboratory animals.

scientific article

Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts.

scientific article published in March 2014

Prefrontal Dopamine D1 and D2 Receptors Regulate Dissociable Aspects of Decision Making via Distinct Ventral Striatal and Amygdalar Circuits.

scientific article published on 25 May 2017

Prefrontal NMDA receptors and cognition: working 2B remembered

scientific article published in February 2013

Prefrontal cortical GABA modulation of spatial reference and working memory.

scientific article published on January 2014

Prefrontal cortical GABA transmission modulates discrimination and latent inhibition of conditioned fear: relevance for schizophrenia

scientific article published on 2 May 2014

Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding

scientific article published on 24 September 2016

Prefrontal cortical and nucleus accumbens contributions to discriminative conditioned suppression of reward-seeking

scientific article published on 15 September 2020

Prefrontal cortical contribution to risk-based decision making.

scientific article published on 5 November 2009

Prefrontal cortical gamma-aminobutyric acid transmission and cognitive function: drawing links to schizophrenia from preclinical research

scientific article

Prefrontal dopamine and behavioral flexibility: shifting from an “inverted-U” toward a family of functions ⬇️

scientific article published on April 19, 2013

Prelimbic and Infralimbic Prefrontal Regulation of Active and Inhibitory Avoidance and Reward-Seeking

scientific article published on 11 May 2020

Receptor-specific modulation of risk-based decision making by nucleus accumbens dopamine.

scientific article published on 29 November 2012

Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia

scientific article published on 10 December 2010

Regional specificity in dopamine signaling during reward-related learning (Commentary on Aragona et al.).

scientific article published on 11 November 2009

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

scientific article published on 2 April 2007

Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABAA transmission: comparison with NMDA transmission.

scientific article published on 24 June 2017

Repeated amphetamine exposure disrupts dopaminergic modulation of amygdala-prefrontal circuitry and cognitive/emotional functioning ⬇️

scientific article published in August 2011

Reversible lesions of the rhinal cortex produce delayed non-matching-to-sample deficits in rats

scientific article published in February 2000

Selective involvement by the medial orbitofrontal cortex in biasing risky, but not impulsive, choice

scientific article published on 4 October 2012

Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay.

scientific article published in March 1997

Separate prefrontal-subcortical circuits mediate different components of risk-based decision making

scientific article published on February 2012

Sex differences in response to amphetamine in adult Long-Evans rats performing a delay-discounting task

scientific article published on 31 December 2013

Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens.

scientific article published in May 1997

Strategy set-shifting and response inhibition in adult rats exposed to an environmental polychlorinated biphenyl mixture during adolescence

scientific article published on 16 August 2017

Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.

scientific article

Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory

scientific article published on 26 May 2006

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

scientific article

Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm maze.

scientific article published in December 1999

Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shifting

scientific article published on 8 September 2006

The Abused Inhalant Toluene Impairs Medial Prefrontal Cortex Activity and Risk/Reward Decision-Making during a Probabilistic Discounting Task

scientific article published on 23 September 2019

The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

scientific article

The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behavior.

scientific article published on 20 April 2007

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

scientific article (publication date: 24 November 2013)

List of works by Stan B. Floresco

A role for neurogenesis in probabilistic reward learning

Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning

Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making ⬇️

Acute stress impairs set-shifting but not reversal learning

Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists

Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder

Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions

Alterations in time-place learning induced by lesions to the rat medial prefrontal cortex

Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine

Androgen Regulation of the Mesocorticolimbic System and Executive Function.

Association Basolateral amygdala stimulation evokes glutamate receptor‐dependent dopamine efflux in the nucleus accumbens of the anaesthetized rat ⬇️

Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex

Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex

Chronic methamphetamine self-administration alters cognitive flexibility in male rats.

Contributions of basolateral amygdala and nucleus accumbens subregions to mediating motivational conflict during punished reward-seeking

Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making

Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues

Cooperative and dissociable involvement of the nucleus accumbens core and shell in the promotion and inhibition of actions during active and inhibitory avoidance

Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation

D-Cycloserine Facilitates Reversal in an Animal Model of Post-traumatic Stress Disorder

D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat.

DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting

Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.

Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia

Differential contributions of nucleus accumbens subregions to cue-guided risk/reward decision making and implementation of conditional rules.

Differential effects of corticotropin-releasing factor and acute stress on different forms of risk/reward decision-making

Differential effects of dopaminergic manipulations on risky choice

Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning

Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information

Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell

Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats ⬇️

Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure

Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making.

Dissociable roles for the nucleus accumbens core and shell in regulating set shifting.

Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making

Dopamine D1 and NMDA receptors mediate potentiation of basolateral amygdala-evoked firing of nucleus accumbens neurons.

Dopamine Neurons, Input Integration, and Reward Prediction Errors: E Pluribus Unum

Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks.

Dopaminergic circuitry and risk/reward decision making: implications for schizophrenia

Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway

Dopaminergic regulation of limbic-striatal interplay.

Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making

Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats

Electrophysiological interactions between striatal glutamatergic and dopaminergic systems

Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex

Fundamental contribution by the basolateral amygdala to different forms of decision making.

Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area

Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.

High levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory

Hyperlocomotion and increased dopamine efflux in the rat nucleus accumbens evoked by electrical stimulation of the ventral subiculum: role of ionotropic glutamate and dopamine D 1 receptors

Involvement of the ventral pallidum in working memory tasks with or without a delay.

Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task.

Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research

Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection.

Modulation of risk/reward decision making by dopaminergic transmission within the basolateral amygdala.

Multifaceted Contributions by Different Regions of the Orbitofrontal and Medial Prefrontal Cortex to Probabilistic Reversal Learning

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.

Neural circuits subserving behavioral flexibility and their relevance to schizophrenia.

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models.

Neuronal Gonadotrophin-Releasing Hormone (GnRH) and Astrocytic Gonadotrophin Inhibitory Hormone (GnIH) Immunoreactivity in the Adult Rat Hippocampus.

Noradrenaline and dopamine: sharing the Workload

Noradrenergic modulation of risk/reward decision making

Operant procedures for assessing behavioral flexibility in rats.

Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior.

Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making

Overriding phasic dopamine signals redirects action selection during risk/reward decision making

Persistent cognitive and morphological alterations induced by repeated exposure of adolescent rats to the abused inhalant toluene

Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

Perturbations in reward-related decision-making induced by reduced prefrontal cortical GABA transmission: Relevance for psychiatric disorders

Pharmacological enhancement of memory and executive functioning in laboratory animals.

Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts.

Prefrontal Dopamine D1 and D2 Receptors Regulate Dissociable Aspects of Decision Making via Distinct Ventral Striatal and Amygdalar Circuits.

Prefrontal NMDA receptors and cognition: working 2B remembered

Prefrontal cortical GABA modulation of spatial reference and working memory.

Prefrontal cortical GABA transmission modulates discrimination and latent inhibition of conditioned fear: relevance for schizophrenia