List of works - Craig J Morton

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate

scientific article published on 14 November 2014

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

scientific article

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

scientific article published on 20 June 2019

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

scientific article published on 02 July 2019

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

scientific article

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

scientific article

Anxiety over GABA(A) receptor structure relieved by AChBP.

scientific article

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency.

scientific article

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

scientific article published on 19 August 2019

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

scientific article

Characterization of -mutant mice with microcytic phenotypes

scientific article published on 01 August 2018

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

scientific article published on 17 June 2019

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

scientific article published on 01 October 2002

Copper binding to the Alzheimer's disease amyloid precursor protein

scientific article

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

scientific article published in Journal of Biological Chemistry

Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis

scientific article

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

scientific article

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

scientific article published on 26 December 2014

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

scientific article published on 18 July 2005

Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.

scientific article published on 21 September 2014

Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.

scientific article published on 22 September 2008

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents

scientific article published on 10 April 2014

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

scientific article published on 19 July 2014

Electrostatic and hydrophobic forces tether the proximal region of the angiotensin II receptor (AT1A) carboxyl terminus to anionic lipids

scientific article

Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy ⬇️

scientific article published on February 27, 1998

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

scientific article

From glutathione transferase to pore in a CLIC.

scientific article

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

scientific article

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.

scientific article

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

scientific article published on 26 April 2006

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

scientific article published on 20 August 2008

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

scientific article published in June 2008

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

scientific article

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

scientific article published in June 2005

Insights into the structural basis for zinc inhibition of the glycine receptor

scientific article published on 9 May 2003

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

scientific article

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

scientific article

Molecular evolution of glutathione S-transferases in the genus Drosophila.

scientific article

Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus

scientific article published in August 2005

NMR studies of the solution properties of recombinant murine interleukin-6

scientific article published on 01 June 1995

Oncogenic protein interfaces: small molecules, big challenges.

scientific article published on 13 March 2014

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

scientific article published on 13 July 2010

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

scientific article

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

scientific article

Protein structure and computational drug discovery

scientific article published on 20 September 2018

Rational design of an organometallic glutathione transferase inhibitor

scientific article

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.

scientific article published on 24 April 2010

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

scientific article published on 9 March 2011

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

scientific article published on 26 November 2015

Solid-state NMR conformational studies of a melittin-inhibitor complex

scientific article published on 22 May 2002

Solution structure and peptide binding of the SH3 domain from human Fyn

scientific article

Solution structure of synthetic peptides corresponding to the C-terminal helix of interleukin-6

scientific article published on 01 January 1994

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

scientific article

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

scientific article published in July 2003

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

scientific article

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

scientific article published on 16 June 2011

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity ⬇️

scientific article published on October 15, 1997

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

scientific article published on 23 April 2019

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

scientific article

The biological function of an insect antifreeze protein simulated by molecular dynamics

scientific article

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.

scientific article published on 15 November 2014

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG

scientific article published on 01 October 1997

The folding kinetics and thermodynamics of the Fyn-SH3 domain.

scientific article

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

scientific article published on 09 November 2018

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.

scientific article published in September 2014

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

scientific article published on 05 August 2019

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

scientific article

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

scientific article published on 23 January 2017

List of works by Craig J Morton

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

Anxiety over GABA(A) receptor structure relieved by AChBP.

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency.

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

Characterization of -mutant mice with microcytic phenotypes

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

Copper binding to the Alzheimer's disease amyloid precursor protein

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.

Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

Electrostatic and hydrophobic forces tether the proximal region of the angiotensin II receptor (AT1A) carboxyl terminus to anionic lipids

Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy ⬇️

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

From glutathione transferase to pore in a CLIC.

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

Insights into the structural basis for zinc inhibition of the glycine receptor

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Molecular evolution of glutathione S-transferases in the genus Drosophila.

Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus

NMR studies of the solution properties of recombinant murine interleukin-6

Oncogenic protein interfaces: small molecules, big challenges.

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Protein structure and computational drug discovery

Rational design of an organometallic glutathione transferase inhibitor

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

Solid-state NMR conformational studies of a melittin-inhibitor complex

Solution structure and peptide binding of the SH3 domain from human Fyn

Solution structure of synthetic peptides corresponding to the C-terminal helix of interleukin-6

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity ⬇️

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

The biological function of an insect antifreeze protein simulated by molecular dynamics

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG

The folding kinetics and thermodynamics of the Fyn-SH3 domain.

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites