List of works - Derek A. Wainwright

A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model

scientific article published on 01 October 2018

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

scientific article published on 16 June 2020

Advanced age negatively impacts survival in an experimental brain tumor model.

scientific article published on August 2016

Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging

scientific article

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

scientific article published on 16 August 2016

CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model.

scientific article

Characterization and immunotherapeutic implications for a novel antibody targeting interleukin (IL)-13 receptor α2.

scientific article

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

scientific article published on 13 December 2018

Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.

scientific article published on 29 May 2015

Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma

scientific article

Developmental therapeutics for patients with breast cancer and central nervous system metastasis: current landscape and future perspectives.

scientific article published on January 2017

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.

scientific article

Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice.

scientific article published on 08 October 2009

Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma

scientific article

Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin

scientific article published on 29 January 2016

Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.

scientific article

IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival

scientific article

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

scientific article published on 2 March 2018

IDO1 in cancer: a Gemini of immune checkpoints.

scientific article published on 29 January 2018

IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection

scientific article

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod

scientific article published on 10 November 2018

Immunotherapy for cancer in the central nervous system: Current and future directions

scientific article

Improving vaccine efficacy against malignant glioma

scientific article published on 10 June 2016

Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer.

scientific article published on 4 May 2018

Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival

scientific article

Management of glioblastoma in elderly patients.

scientific article

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy.

scientific article

Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

scientific article published on 15 May 2014

Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy ⬇️

scientific article published on July 21, 2013

Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma.

scientific article published on 4 February 2017

Recent developments on immunotherapy for brain cancer

scientific article

Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model.

scientific article

Targeting Tregs in Malignant Brain Cancer: Overcoming IDO.

scientific article published on 15 May 2013

The Boosting Potential of Bacteria in Cancer Immunotherapy

scientific article published on 2 June 2017

The Challenge for Gene Therapy: Innate Immune Response to Adenoviruses ⬇️

scientific article published on March 1, 2011

The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine.

scientific article published on 9 September 2016

The expression of BST2 in human and experimental mouse brain tumors.

scientific article

The interplay among psychological distress, the immune system, and brain tumor patient outcomes

scientific article published on 26 February 2019

The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy

scientific article

The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma

scientific article

The role of IDO in brain tumor immunotherapy

scientific article

Therapeutic Hypothesis Testing With Rodent Brain Tumor Models.

scientific article published on 20 March 2017

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors ⬇️

scientific article published on September 8, 2011

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.

scientific article published on 18 February 2016

Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation

scientific article published on 22 July 2021

Updates from the Neuro-Oncology Section of the 2015 American Neurological Association Annual Meeting

scientific article published on 30 November 2015

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.

scientific article published on 19 September 2017

List of works by Derek A. Wainwright

A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

Advanced age negatively impacts survival in an experimental brain tumor model.

Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model.

Characterization and immunotherapeutic implications for a novel antibody targeting interleukin (IL)-13 receptor α2.

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.

Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma

Developmental therapeutics for patients with breast cancer and central nervous system metastasis: current landscape and future perspectives.

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors.

Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice.

Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma

Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin

Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.

IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

IDO1 in cancer: a Gemini of immune checkpoints.

IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod

Immunotherapy for cancer in the central nervous system: Current and future directions

Improving vaccine efficacy against malignant glioma

Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer.

Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival

Management of glioblastoma in elderly patients.

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy.

Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy ⬇️

Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma.

Recent developments on immunotherapy for brain cancer

Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model.

Targeting Tregs in Malignant Brain Cancer: Overcoming IDO.

The Boosting Potential of Bacteria in Cancer Immunotherapy

The Challenge for Gene Therapy: Innate Immune Response to Adenoviruses ⬇️

The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine.

The expression of BST2 in human and experimental mouse brain tumors.

The interplay among psychological distress, the immune system, and brain tumor patient outcomes

The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy

The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma

The role of IDO in brain tumor immunotherapy

Therapeutic Hypothesis Testing With Rodent Brain Tumor Models.

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors ⬇️

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium.

Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation

Updates from the Neuro-Oncology Section of the 2015 American Neurological Association Annual Meeting

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.