List of works by Oliver Howes

'Truman' signs and vulnerability to psychosis.

scientific article

30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis

scientific article

A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis

scientific article published on 01 September 2019

A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia

scientific article published on 11 October 2017

A comprehensive review and model of putative prodromal features of bipolar affective disorder.

scientific article published on 14 September 2010

A neurobiological hypothesis for the classification of schizophrenia: type A (hyperdopaminergic) and type B (normodopaminergic).

scientific article published in July 2014

A potential biomarker for treatment stratification in psychosis: evaluation of an [18F] FDOPA PET imaging approach

scientific article published on 22 September 2020

A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance

scientific article published on February 2004

ALTERATIONS IN BRAIN STRUCTURE, FUNCTION AND CHEMISTRY PRIOR TO THE ONSET OF PSYCHOSIS

Abnormal P300 in people with high risk of developing psychosis.

scientific article published on 4 January 2008

Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study

scientific article published on July 2010

Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis

scientific article published in December 2009

Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis

scientific article

Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study

scientific article

Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors

scientific article published on 3 November 2017

Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation

scientific article published on 06 September 2012

Adversity in childhood linked to elevated striatal dopamine function in adulthood

scientific article published on 23 June 2016

Alendronic acid for antipsychotic-related osteopenia

scientific article published in April 2004

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies

scientific article published on June 2014

Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies

scientific article published on 24 June 2014

Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis

scientific article

Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications

scientific article published on 28 February 2019

Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis

scientific article published on 17 July 2010

An initial investigation of abnormal bodily phenomena in subjects at ultra high risk for psychosis: Their prevalence and clinical implications

scientific article

An overview of functional, structural and neurochemical imaging studies in individuals with a clinical high risk for psychosis

Antipsychotic drugs for prevention of relapse

scientific article published on 3 May 2012

Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia.

scientific article published on 26 October 2017

Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors.

scientific article published on 11 April 2017

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.

scientific article published on 25 July 2013

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

scientific article published on 01 June 2021

Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis

scientific article published on 15 March 2017

Associative blocking to reward-predicting cues is attenuated in ketamine users but can be modulated by images associated with drug use.

scientific article

Authors' reply

Authors' reply

Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment

scientific article published on June 2005

Bone mineral density and prolactin associations in patients with chronic schizophrenia

scientific article published in January 2004

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [(11)C]PBR28 study

scientific article published on 8 September 2017

Calculating occupancy when one does not have baseline: a comparison of different options

scientific article

Cannabis use and transition to psychosis in people at ultra-high risk

scientific article published in September 2014

Characterization of the anterior cingulate's role in the at-risk mental state using graph theory.

scientific article published on 22 February 2011

Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis.

scientific article published on 5 October 2017

Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging

scientific article published on 11 October 2008

Cognitive functioning in prodromal psychosis: a meta-analysis

scientific article

Cognitive therapy: at last an alternative to antipsychotics?

scientific article published in The Lancet

Comment on Hyperprolactinaemia and antipsychotic therapy in schizophrenia

scientific article published on 01 October 2004

Commentary on a study of the prevalence of mental disorders by Breslau et al.

scientific article

Comments on "Prolactin levels and erectile function in patients treated with risperidone" (J Clin Psychopharmacol 2004;24:161-166).

scientific article published in August 2005

Compulsions in depression: stalking by text message

scientific article

Correction to: Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models

scientific article published on 01 June 2019

Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

scientific article published on 01 December 2018

Cortical GABA In Subjects At Ultra-High Risk Of Psychosis: Relationship To Negative Prodromal Symptoms.

scientific article

Decreased regional gray matter volume in S’ allele carriers of the 5-HTTLPR triallelic polymorphism

scientific article published on 02 November 2010

Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: a longitudinal study

scientific article published on 8 October 2010

Diabetic keto-acidotic (DKA) coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine

scientific article published in September 2004

Does human presynaptic striatal dopamine function predict social conformity?

scientific article published on 20 November 2013

Dopamine function in cigarette smokers: an [¹⁸F]-DOPA PET study

scientific article

Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study

scientific article published on 18 July 2011

Dopamine synthesis capacity in patients with treatment-resistant schizophrenia

scientific article published in November 2012

Dopamine transporter imaging: nonindependence of regional measures

scientific article published on 4 March 2014

Dopaminergic basis of salience dysregulation in psychosis

scientific article published on 02 January 2014

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

scientific article published on 29 June 2013

Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations

scientific article published on 26 January 2012

Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase

scientific article

Early detection and intervention in bipolar affective disorder: targeting the development of the disorder

scientific article published on December 2011

Economic impact of early detection and early intervention of psychosis

scientific article published on January 2012

Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study.

scientific article published on 4 August 2017

Effect of clozapine on mortality

scientific article published in November 2003

Effect of lifestyle, medication and ethnicity on cardiometabolic risk in the year following the first episode of psychosis: prospective cohort study

scientific article published on 01 December 2019

Effects of citalopram on serotonin neurotransmission

scientific article published on 01 December 2012

Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.

scientific article

Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis.

scientific article published on 5 January 2017

Elevated striatal dopamine function linked to prodromal signs of schizophrenia

scientific article published in January 2009

Facial and prosodic emotion recognition deficits associate with specific clusters of psychotic symptoms in schizophrenia

scientific article published on 20 June 2013

First-Episode Schizophrenia and Diabetes Risk—Reply

scientific article published on 01 July 2017

From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments

scientific article published on January 2012

Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis

scientific article published on 23 September 2012

Functional neuroimaging in schizophrenia: diagnosis and drug discovery

scientific article

Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation

scientific article

Functionally defined regions may aid interpretation of striatal dopamine elevation in schizophrenia

scientific article published on 27 February 2009

Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding

scientific article published on April 2010

Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum

scientific article published on 25 March 2015

Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities

scientific article published in January 2017

Glutamate and dopamine in schizophrenia: an update for the 21st century

scientific article published on 13 January 2015

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users

scientific article published on 22 November 2013

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

scientific article published on 16 October 2019

Health anxiety in medical students

scientific article published in May 1998

Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia: A Meta-analysis

scientific article published on 27 September 2017

History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability

scientific article published on 2 September 2011

Hyperprolactinaemia caused by antipsychotic drugs. Endocrine antipsychotic side effects must be systemically assessed

scientific article

Hyperprolactinaemia in first episode psychosis - A longitudinal assessment.

scientific article

Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis.

scientific article published on 11 January 2017

Impaired verbal self-monitoring in individuals at high risk of psychosis.

scientific article published on 2 December 2009

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

scientific article

Inflammation: its role in schizophrenia and the potential anti-inflammatory effects of antipsychotics

scientific article published on 01 January 2014

Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

scientific article published on 13 October 2020

Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance

scientific article published in 2022

Interpersonal sensitivity in the at-risk mental state for psychosis.

scientific article

Interpreting the neurodevelopmental hypothesis of schizophrenia in the context of normal brain development and ageing

scientific article published on 4 May 2015

Is antipsychotic treatment linked to low bone mineral density and osteoporosis? A review of the evidence and the clinical implications

scientific article published on 09 January 2012

Is clinical intervention in the ultra high risk phase effective?

scientific article published on October 2011

Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models

scientific article published on 09 May 2018

Johann Cristian Reil on the 200th anniversary of the first description of the insula (1809).

scientific article published in December 2009

Julius Wagner-Jauregg, 1857-1940.

scientific article published in April 2009

Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators

scientific article published on April 2012

Long-Term Heavy Ketamine Use is Associated with Spatial Memory Impairment and Altered Hippocampal Activation.

scientific article

Longitudinal PET imaging in a patient with schizophrenia did not show marked changes in dopaminergic function with relapse of psychosis

scientific article

Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis

scientific article published on 10 January 2020

Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies

scientific article

Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study.

scientific article published on 5 June 2012

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.

scientific article published on January 2009

Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study

scientific article published on 03 October 2013

Mind the mortality gap: the importance of metabolic function in mental illnesses

scientific article

Mind the translation gap: problems in the implementation of early intervention services.

scientific article published on 7 September 2009

Misattributing speech and jumping to conclusions: a longitudinal study in people at high risk of psychosis

scientific article published on 12 December 2014

Molecular imaging as a guide for the treatment of central nervous system disorders

scientific article published on September 2013

Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis

scientific article published on December 2007

Multimodal functional imaging investigation before and after the onset of psychosis

scientific article

Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study

scientific article

Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis

scientific article published on 12 December 2012

Neuropathological changes in the substantia nigra in schizophrenia but not depression.

scientific article published on 29 December 2013

Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia.

scientific article published on 3 December 2008

Optimising treatment of refractory schizophrenia

scientific article published on 09 April 2013

Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method

scientific article published on 13 March 2013

Pathways to schizophrenia: the impact of environmental factors

scientific article published on March 2004

Practitioner attitudes to clozapine initiation

scientific article published on 05 September 2013

Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship

scientific article published on 21 December 2011

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

scientific article published on 30 January 2018

Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain

scientific article

Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study.

scientific article published on May 2014

Presynaptic dopaminergic function: implications for understanding treatment response in psychosis

scientific article

Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort.

scientific article

Prevalence and implications of Truman symptoms in subjects at ultra high risk for psychosis

scientific article

Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis

scientific article

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study.

scientific article published on March 2011

Pseudohallucinations Versus True Hallucinations in Prodromal Psychosis

article by Paolo Fusar-Poli et al published 15 July 2009 in The Journal of Clinical Psychiatry

Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example

scientific article published on 3 August 2011

Reduced mismatch negativity predates the onset of psychosis

scientific article published on 24 October 2011

Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.

scientific article

Relationship between brain glutamate levels and clinical outcome in individuals at ultra high risk of psychosis

scientific article

Reply to: Hippocampal Glutamate Levels and Striatal Dopamine D 2/3 Receptor Occupancy in Subjects at Ultra High Risk of Psychosis

scholarly article by James M. Stone et al published July 2011 in Biological Psychiatry

Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis

scientific article published on 18 December 2015

Schizophrenia: an integrated sociodevelopmental-cognitive model

scientific article

Sensory gating deficits in the attenuated psychosis syndrome

scientific article published on 30 December 2014

Serum glutamic acid decarboxylase 65 antibody levels in people with schizophrenia and their families

scientific article published in March 2005

Sex hormone augmentation as an adjunctive treatment in schizophrenia.

scientific article

Sexual dysfunction in people with prodromal or first-episode psychosis.

scientific article

Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder.

scientific article published on March 2007

Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [18 F]-FDOPA PET study.

scientific article published on 26 October 2017

Spatial working memory ability in individuals at ultra high risk for psychosis

scientific article

Street slang and schizophrenia

scientific article published on December 2007

Striatal dopamine synthesis capacity in twins discordant for schizophrenia

scientific article published on 22 March 2011

Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [(99m)Tc]-TRODAT-1 and a meta-analysis

scientific article published on 8 December 2011

Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory

scientific article published on 10 July 2019

Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

scientific article

The Enduring Centrality of Dopamine in the Pathophysiology of Schizophrenia

scholarly article published 2014

The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An 18F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients

scientific article published in 2022

The Role of Antipsychotic Plasma Levels in the Treatment of Schizophrenia.

scientific article

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study

scientific article published on 21 April 2012

The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment

scientific article

The dopamine hypothesis of schizophrenia: version III--the final common pathway

scientific article

The dopaminergic basis of human behaviors: A review of molecular imaging studies

scientific article published on 27 May 2009

The effect of ageing on grey and white matter reductions in schizophrenia

scientific article published on 17 May 2009

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

scientific article published on 28 November 2017

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

scientific article

The enduring centrality of dopamine in the pathophysiology of schizophrenia: in vivo evidence from the prodrome to the first psychotic episode.

scientific article

The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review.

scientific article published on 31 January 2017

The importance of venous thromboembolism - a physical consequence of psychiatric treatments

scientific article published on 01 July 2010

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study.

scientific article published on 3 April 2014

The nature of dopamine dysfunction in schizophrenia and what this means for treatment

scientific article published on August 2012

The practical management of refractory schizophrenia--the Maudsley Treatment REview and Assessment Team service approach.

scientific article published on 09 September 2014

The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study

scientific article

The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole

scientific article published on 28 December 2012

The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients

scientific article published on December 2006

The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET.

scientific article

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

scientific article published on 17 July 2021

The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression

scientific article published on 31 July 2015

The synaptic hypothesis of schizophrenia version III: a master mechanism

scientific article published in 2023

The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function

scientific article

The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study

scientific article published on 19 April 2011

Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals

scientific article

Translation and cross-cultural adaptation of the Sexual Function Questionnaire (SFQ) into Brazilian Portuguese

scientific article

Treating negative symptoms of schizophrenia: current approaches and future perspectives

scientific article published in 2023

Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms

scientific article published on 18 March 2015

Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics

scientific article published in October 2008

Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study

scientific article

Vitamin D deficiency in first episode psychosis: a case-control study

scientific article published on 20 September 2013

manongarivo Environmentally friendly health care begins in Madagascar

scientific article published in The Lancet

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