List of works - Kyle L. Hoehn

A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.

scientific article

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

scientific article published in Nature Communications

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses

scientific article

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

scientific article

Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy.

scientific article

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

scientific article published on 17 August 2015

Analysis of the circular RNA transcriptome in endometrial cancer.

scientific article published on 20 December 2017

Assaying AKT/protein kinase B activity

scientific article published on January 2003

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

scientific article

CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms

scientific article published on 23 September 2019

CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes

scientific journal article

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function

scientific article published on 30 January 2019

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

scientific article

Defining Eosinophil Function in Adiposity and Weight Loss

scientific article published on 22 August 2018

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice

scientific article

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

scientific article published on 01 December 2019

Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine

scientific article

Dietary sugar intake increases liver tumor incidence in female mice

scientific article

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

scientific article published on 17 October 2018

Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection

scientific article

Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition

scientific article published on 18 January 2018

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

scientific article published in December 2017

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

scientific article published on 10 June 2020

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

scientific article

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

scientific article published on 22 May 2007

Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring

scientific article

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

scientific article

Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3

scientific article

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

scientific article published on 13 February 2018

IRS1-independent defects define major nodes of insulin resistance

scientific article

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

scientific article

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells

scientific article published on 01 January 2019

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

scientific article

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

scientific article

Insulin resistance is a cellular antioxidant defense mechanism

scientific article

Knockout of glucose transporter GLUT6 has minimal effects on whole-body metabolic physiology in mice.

scientific article published on 17 April 2018

Lipid mediators of insulin resistance

scientific article published on June 2007

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.

scientific article

Metabolic vulnerabilities in endometrial cancer

scientific article

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

scientific article published on 14 December 2015

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

scientific article

Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors

scientific article

Mitochondrial regulation of insulin action

scientific article

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

scientific article published on 14 May 2020

Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer.

scientific article

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

scientific article

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

scientific article

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice

scientific article published on May 2012

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

scientific article published in June 2012

Pigment epithelium-derived factor contributes to insulin resistance in obesity.

scientific article published in July 2009

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

scientific article published on 25 June 2004

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity

scientific article

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

scientific article

Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators

scientific article

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth

Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation

scientific article

Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.

scientific article

Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.

scientific article

Subclassification of fatty liver by its pathogenesis: cIEFing is believing

scientific article published on 16 February 2016

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

scientific article published on 01 January 2019

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

scientific article

The emerging role of long non-coding RNAs in endometrial cancer

scientific article

The race to find endometrial cancer biomarkers

scientific article published on 8 February 2017

The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil.

scientific article published on 12 December 2012

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes

scientific article published on 29 January 2018

Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer

scientific article published on 16 October 2017

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition

scientific article

UGCG influences glutamine metabolism of breast cancer cells

scientific article published on 30 October 2019

Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life

scientific article

List of works by Kyle L. Hoehn

A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy.

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

Analysis of the circular RNA transcriptome in endometrial cancer.

Assaying AKT/protein kinase B activity

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms

CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

Defining Eosinophil Function in Adiposity and Weight Loss

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine

Dietary sugar intake increases liver tumor incidence in female mice

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection

Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

IRS1-independent defects define major nodes of insulin resistance

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Insulin resistance is a cellular antioxidant defense mechanism

Knockout of glucose transporter GLUT6 has minimal effects on whole-body metabolic physiology in mice.

Lipid mediators of insulin resistance

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.

Metabolic vulnerabilities in endometrial cancer

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors

Mitochondrial regulation of insulin action

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer.

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

Pigment epithelium-derived factor contributes to insulin resistance in obesity.

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth

Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation

Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.

Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.

Subclassification of fatty liver by its pathogenesis: cIEFing is believing

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

The emerging role of long non-coding RNAs in endometrial cancer

The race to find endometrial cancer biomarkers

The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes

Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition

UGCG influences glutamine metabolism of breast cancer cells

Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life