List of works - Takamasa Ueno

A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection

scientific article published in February 1999

A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome.

scientific article

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion

scientific article published on 25 August 2015

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses

scientific article published on 25 August 2021

Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection

scientific article

Attenuation of multiple Nef functions in HIV-1 elite controllers

scientific article published on 7 January 2013

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope

scientific article

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

article

Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.

scientific article published on June 2015

Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay

scientific article published on February 1997

Conserved Vδ1 binding geometry in a setting of locus-disparate pHLA recognition by δ/αβTCRs: insight into recognition of HIV peptides by TCR.

scientific article published on 14 June 2017

Cross-reactivity analysis of T cell receptors specific for overlapping HIV-1 Nef epitopes of different lengths.

scientific article

Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope

scientific article published in May 2008

Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan

scientific article published on 01 June 1998

Different in vivo effects of HIV-1 immunodominant epitope-specific cytotoxic T lymphocytes on selection of escape mutant viruses.

scientific article published on 24 March 2010

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

scientific article

Domain structures of the MS ring component protein (FliF) of the flagellar basal body of Salmonella typhimurium.

scientific article

Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection ⬇️

scientific article published on July 7, 2010

Dynamic range of Nef functions in chronic HIV-1 infection

scientific article published on 13 March 2013

Dynamic range of Nef-mediated evasion of HLA class II-restricted immune responses in early HIV-1 infection

scientific article

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

scientific article

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.

scientific article published on 22 June 2011

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

scientific article

Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells

scientific article

Flagellar filament elongation can be impaired by mutations in the hook protein FlgE of Salmonella typhimurium: a possible role of the hook as a passage for the anti-sigma factor FlgM.

scientific article published on March 1998

Functionally impaired HIV-specific CD8 T cells show high affinity TCR-ligand interactions.

scientific article published in November 2004

HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations.

scientific article published on 30 January 2017

HLA class I-restricted recognition of an HIV-derived epitope peptide by a human T cell receptor alpha chain having a Vdelta1 variable segment.

scientific article published on October 2003

Identification of two unique naturally occurring Vpr sequence polymorphisms associated with clinical parameters in HIV-1 chronic infection.

scientific article

Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral activity of HIV-specific CTL.

scientific article published in May 2009

Impaired Nef function is associated with early control of HIV-1 viremia

scientific article published on 25 June 2014

Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target.

scientific article published in August 2002

Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety

scientific article published on 01 May 2000

Inhibition of telomerase by linear-chain fatty acids: a structural analysis.

scientific article

Inhibition of the hepatitis C virus NS3 protease activity by Fv fragment of antibody 8D4.

scientific article published in February 2001

M ring, S ring and proximal rod of the flagellar basal body of Salmonella typhimurium are composed of subunits of a single protein, FliF.

scientific article published on October 1992

Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu.

scientific article published on 7 April 2012

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

scientific article published on 20 March 2015

Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels

scientific article published on 24 February 2016

Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection.

scientific article published on 17 November 2010

Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex.

scientific article published on 15 July 2014

Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes

scientific article published on 01 December 2004

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

scientific article

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

scientific article published on 18 October 2017

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation

scientific article

Selection of TI8-8V mutant associated with long-term control of HIV-1 by cross-reactive HLA-B*51:01-restricted cytotoxic T cells

scientific article published on 10 October 2014

Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA class I molecules

scientific article published on 01 November 2002

Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.

scientific article

Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress human immunodeficiency virus type 1 (HIV-1) replication in HIV-1-infected CD4+ T cells and macrophages

scientific article published on 20 May 2009

Structural analysis of chick ephrin-A2 by function-blocking and non-blocking monoclonal antibodies.

scientific article

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.

scientific article published in September 2000

Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models

scientific article published on 01 December 2000

The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity ⬇️

scientific article published on April 1, 1998

The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin

scientific article published on 01 October 2000

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement

scientific article

The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication

scientific article published in January 2002

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

scientific article published on 02 May 2022

List of works by Takamasa Ueno

A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection

A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome.

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses

Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection

Attenuation of multiple Nef functions in HIV-1 elite controllers

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.

Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay

Conserved Vδ1 binding geometry in a setting of locus-disparate pHLA recognition by δ/αβTCRs: insight into recognition of HIV peptides by TCR.

Cross-reactivity analysis of T cell receptors specific for overlapping HIV-1 Nef epitopes of different lengths.

Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope

Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan

Different in vivo effects of HIV-1 immunodominant epitope-specific cytotoxic T lymphocytes on selection of escape mutant viruses.

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

Domain structures of the MS ring component protein (FliF) of the flagellar basal body of Salmonella typhimurium.

Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection ⬇️

Dynamic range of Nef functions in chronic HIV-1 infection

Dynamic range of Nef-mediated evasion of HLA class II-restricted immune responses in early HIV-1 infection

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells

Flagellar filament elongation can be impaired by mutations in the hook protein FlgE of Salmonella typhimurium: a possible role of the hook as a passage for the anti-sigma factor FlgM.

Functionally impaired HIV-specific CD8 T cells show high affinity TCR-ligand interactions.

HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations.

HLA class I-restricted recognition of an HIV-derived epitope peptide by a human T cell receptor alpha chain having a Vdelta1 variable segment.

Identification of two unique naturally occurring Vpr sequence polymorphisms associated with clinical parameters in HIV-1 chronic infection.

Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral activity of HIV-specific CTL.

Impaired Nef function is associated with early control of HIV-1 viremia

Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target.

Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety

Inhibition of telomerase by linear-chain fatty acids: a structural analysis.

Inhibition of the hepatitis C virus NS3 protease activity by Fv fragment of antibody 8D4.

M ring, S ring and proximal rod of the flagellar basal body of Salmonella typhimurium are composed of subunits of a single protein, FliF.

Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu.

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels

Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection.

Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex.

Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation

Selection of TI8-8V mutant associated with long-term control of HIV-1 by cross-reactive HLA-B*51:01-restricted cytotoxic T cells

Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA class I molecules

Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.

Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress human immunodeficiency virus type 1 (HIV-1) replication in HIV-1-infected CD4+ T cells and macrophages

Structural analysis of chick ephrin-A2 by function-blocking and non-blocking monoclonal antibodies.

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.

Suppressive effect of topically applied CX-659S, a novel diaminouracil derivative, on the contact hypersensitivity reaction in various animal models

The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity ⬇️

The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement

The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike