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List of works by Roland Lang

A Severe Case of Tuberculosis Radiologically and Endoscopically Mimicking Colorectal Cancer with Peritoneal Carcinomatosis.

scientific article published on 3 October 2017

A Specific Reduction in Aβ1-42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis.

scientific article published on 24 May 2018

A genome-wide analysis of LPS tolerance in macrophages

scientific article published on 19 November 2007

A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages

scientific article

A rapid method for semiquantitative analysis of the human Vβ-repertoire using TaqManR PCR

scientific article published on 01 April 1997

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance

scientific article

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

scientific article

Airborne indoor particles from schools are more toxic than outdoor particles

scientific article published on 16 August 2012

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

scientific article

Analysis of Corynebacterium diphtheriae macrophage interaction: Dispensability of corynomycolic acids for inhibition of phagolysosome maturation and identification of a new gene involved in synthesis of the corynomycolic acid layer

scientific article published on 7 July 2017

Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity

scientific article published on 26 June 2009

Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors

scientific article published on 21 November 2016

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis

scientific article published on 21 November 2017

Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1).

scientific article published on 20 October 2016

CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

scientific article published on 13 October 2020

Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements

scientific article

Cellular target genes of Epstein-Barr virus nuclear antigen 2.

scientific article

Class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II.

scientific article published on 2 November 2014

Comparison of Methods for Splitting of Touching and Overlapping Macrophages in Fluorescent Micrographs

Comparison of gene expression profiles between human and mouse monocyte subsets

scientific article

Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors

scientific article published on February 2017

Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

scientific article published on 22 July 2015

Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10.

scientific article

CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12

article by K Kranzer et al published February 2000 in Immunology

Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity

scientific article published on 15 June 2020

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

scientific article

Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection

scientific article published on August 2004

Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment.

scientific article

Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α.

scientific article

Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes

scientific article published on 03 July 2009

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function

scientific article published on 06 September 2019

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

scientific article published on 27 December 2005

Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool

scientific article published on 9 November 2017

Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.

scientific article

Enhancing automated micrograph-based evaluation of LPS-stimulated macrophage spreading

scientific article published on 10 January 2013

Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori

scientific article

Fatal Mycotic Aneurysm of the Basilar Artery Caused by Aspergillus fumigatus in a Patient with Pituitary Adenoma and Meningitis

scientific article

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

scientific article

Focal encephalitis in the Lewis rat induced by intracerebral enterotoxin superantigen and amplified by activated intravenous splenocytes

scientific article

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

scientific article published on 5 March 2018

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production

scientific article published on 5 December 2013

Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes

scientific article

Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms

scientific article published on 10 October 2006

Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling

scientific article

Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice

scientific article

Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation

scientific article

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells

scientific article published on 29 May 2014

IL-1α reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy?

scientific article

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance

scientific article published on 03 June 2016

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells

scientific article published in February 2004

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.

scientific article

Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.

scientific article published on 18 May 2010

Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.

scientific article

Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK.

scientific article published on 17 September 2008

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

scientific article

Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis

scientific article published in July 2007

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-β production in myeloid dendritic cells

scientific article published on 01 February 2007

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

scientific article

Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling

scientific article published on 11 January 2019

Measurement of TLR-Induced Macrophage Spreading by Automated Image Analysis: Differential Role of Myd88 and MAPK in Early and Late Responses

scientific article published on 18 October 2011

Mincle is not essential for controlling Mycobacterium tuberculosis infection.

scientific article published on 21 June 2012

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

scientific article published on 2 March 2016

MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae

scientific article published on 20 March 2007

Mycobacteria-induced granuloma necrosis depends on IRF-1.

scientific article

Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1

scientific article published on 12 August 2020

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

Of mice and men: Interaction of Corynebacterium diphtheriae strains with murine and human phagocytes

scientific article published on 01 December 2019

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

scholarly article

Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis

scientific article published on June 2006

Over expression of IL-10 by macrophages overcomes resistance to murine filariasis

scientific article published on 19 September 2011

Pronounced phenotype in activated regulatory T cells during a chronic helminth infection

scientific article from 2010

Proteins of the secretory pathway govern virus productivity during lytic gammaherpesvirus infection

scientific article published on 11 January 2008

Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis ⬇️

scientific article published on January 24, 2013

Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage

scientific article published on 22 December 2017

Role of viral factor E3L in modified vaccinia virus ankara infection of human HeLa Cells: regulation of the virus life cycle and identification of differentially expressed host genes

scientific article

SOCS3 regulates the plasticity of gp130 signaling

scientific article

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

scientific journal article

Segmentierung von Makrophagen in Fluoreszenzbildern mittels Fast Marching Level Set Verfahren

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production

scientific article published on 13 July 2015

Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4

scientific article

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

scientific article published on 10 November 2017

Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus

scientific article

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions

scientific article published on 21 June 2011

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response

scientific article

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling

scientific article

The phosphoproteome of toll-like receptor-activated macrophages

scientific article published on June 2010

The role of lipids in host microbe interactions.

scientific article

Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids

scientific article published on 14 December 2007

Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoids

Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids

scientific article published on 8 May 2017

Toll-Like Receptor–Dependent Activation of Antigen-Presenting Cells Affects Adaptive Immunity to Helicobacter pylori

scientific article published on 03 May 2007

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

article

Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint

scientific article published in April 2012

Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling

scientific article published on October 2004

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo

scientific article published on June 2016

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling

scientific article

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

scientific article published on 19 June 2009

Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection

scientific article

Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention

scientific article published on 26 September 2017

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

scientific article published on 20 April 2015

Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets

scientific article

Using multimodal information for the segmentation of fluorescent micrographs with application to virology and microbiology

scientific article

WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG.

scientific article published in April 2005

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