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List of works by Arn van den Maagdenberg

A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression

scientific article (publication date: 4 March 2004)

A high-density association screen of 155 ion transport genes for involvement with common migraine

scientific article

A metabolomic profile is associated with the risk of incident coronary heart disease

scientific article published on 4 April 2014

A miniaturized push-pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain

scientific article published on 01 April 2019

Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments

scientific article (publication date: 2013)

Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans

scientific article

Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

scientific article

Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1.

scientific article

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice

scientific article published on October 2009

Apnea Associated with Brainstem Seizures in Cacna1a S218L Mice Is Caused by Medullary Spreading Depolarization

scientific article published on 18 October 2019

Automated Ischemic Lesion Segmentation in MRI Mouse Brain Data after Transient Middle Cerebral Artery Occlusion

scientific article

Automated segmentation of in vivo and ex vivo mouse brain magnetic resonance images

scientific article published in January 2009

Automatic generic registration of mass spectrometry imaging data to histology using nonlinear stochastic embedding

scientific article

Automatic registration of mass spectrometry imaging data sets to the Allen brain atlas

scientific article

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

scientific article

CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures

scientific article

Calcium channel mutations and migraine

scientific article

Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators inCacna1aS218LMutant Mice ⬇️

scientific article published on October 31, 2012

Cerebellar output controls generalized spike-and-wave discharge occurrence

scientific article published on June 2015

Clinical and genetic aspects of idiopathic epilepsies in childhood

scientific article

Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood-a study of 155 patients

scientific article

Coding of facial expressions of pain in the laboratory mouse

scientific article

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families

article by Padhraig Gormley et al published September 2018 in Neuron

Comprehensive analysis of the mouse brain proteome sampled in mass spectrometry imaging

scientific article published on 13 January 2015

Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies

scientific article published on September 2014

Conditional inactivation of the Cacna1a gene in transgenic mice

scientific article published in December 2006

Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel ⬇️

scientific article published on October 11, 2010

Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine

scientific article published on 31 March 2016

De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila

scientific article

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

scientific article

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

scientific article published on 18 April 2017

Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study

scientific article published on 17 December 2013

Distinct neurological disorders with ATP1A3 mutations

scientific article

Divergent sodium channel defects in familial hemiplegic migraine

scholarly article

Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice

scientific article

Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study

scientific article published on January 2017

Epigenetic mechanisms in migraine: a promising avenue? ⬇️

scientific article published on February 4, 2013

Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake

scientific article

Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article published in October 2016

Ethanol contamination of cerebrospinal fluid during standardized sampling and its effect on (1)H-NMR metabolomics

scientific article published on 3 May 2015

Familial cortical myoclonic tremor with epilepsy: a single syndromic classification for a group of pedigrees bearing common features

scientific article

Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

scientific article

Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions

scientific article

Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects

scientific article

First FHM3 mouse model shows spontaneous cortical spreading depolarizations

scientific article published on 27 December 2019

Focal and generalized seizure activity after local hippocampal or cortical ablation of NaV 1.1 channels in mice

scientific article published on 19 March 2020

From migraine genes to mechanisms

scientific article published on April 2015

Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine

scientific article

Funnel-freezing versus heat-stabilization for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model

scientific article

Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential

scientific article

Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas

scientific article published on 22 February 2016

Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness

scientific article published in January 2005

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

scientific article published on 8 December 2015

Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

scientific article published on 14 July 2021

Genetic analysis for a shared biological basis between migraine and coronary artery disease

scientific article published on June 2015

Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.

scientific article

Genetic models of migraine

scientific article published on May 2007

Genetics of migraine: an update with special attention to genetic comorbidity

scientific article

Genome-wide association analysis identifies susceptibility loci for migraine without aura

scientific article

Genome-wide association studies in migraine: current state and route to follow

scientific article published on 10 March 2016

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.

scientific article

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

scientific article

Genome-wide meta-analysis identifies new susceptibility loci for migraine

scientific article

High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice

scientific article

Identifying a gene expression signature of cluster headache in blood

scientific article published on 11 January 2017

Imaging mass spectrometry to visualize biomolecule distributions in mouse brain tissue following hemispheric cortical spreading depression

scientific article

In silico phenotyping via co-training for improved phenotype prediction from genotype

scientific article

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

scientific article published on 12 May 2016

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses

scientific article

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Involvement of astrocyte and oligodendrocyte gene sets in migraine

scientific article published on 7 December 2015

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Limited regional cerebellar dysfunction induces focal dystonia in mice ⬇️

scientific article published on July 28, 2012

MRI Mouse Brain Data of Ischemic Lesion after Transient Middle Cerebral Artery Occlusion

scientific article published on 6 September 2017

Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice

scientific article

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

scientific article

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

scientific article

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolomic changes in CSF of migraine patients measured with 1H-NMR spectroscopy

scientific article published on 13 October 2016

Migraine and epilepsy: genetically linked?

scientific article

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

scientific article

Migraine genetics: an update

scientific article

Migraine is not associated with enhanced atherosclerosis

scientific article published on 12 November 2012

Migraine mutations impair hippocampal learning despite enhanced long-term potentiation

scientific article

Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations

scientific article published on 5 December 2011

Migraine pathophysiology: lessons from mouse models and human genetics

scientific article

Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice

scientific article

Migraine: gene mutations and functional consequences

scientific article published on June 2007

Migraine: new treatment options from molecular biology

scientific article

Molecular genetics of migraine

scientific article

Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine

scientific article (publication date: June 2002)

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine

scientific article

Mutations in DEPDC5 cause familial focal epilepsy with variable foci

scientific journal article

Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease

scientific article

Novel hypotheses emerging from GWAS in migraine?

scientific article published on 11 January 2019

Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions

scientific article (publication date: September 2003)

Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice

scientific article

Pearls and pitfalls in genetic studies of migraine ⬇️

scientific article published on June 1, 2013

Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis--mass spectrometry

scientific article published on May 2015

Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held ⬇️

scientific article published on September 5, 2012

Progression and Classification of Granular Osmiophilic Material (GOM) Deposits in Functionally Characterized Human NOTCH3 Transgenic Mice

scientific article published on 30 October 2019

Purkinje cell-specific ablation of Cav2.1 channels is sufficient to cause cerebellar ataxia in mice ⬇️

scientific article published on March 1, 2012

Recent findings in headache genetics

scientific article published on June 2004

Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction

scientific journal article

Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations

scientific article published on 6 September 2016

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.

scientific article published in May 2015

Shared genetic factors in migraine and depression: evidence from a genetic isolate

scientific article

Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants

scientific article published on 28 September 2017

Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma

scientific article (publication date: 6 May 2005)

Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid hemorrhage

scientific article published on 30 November 2015

Startle syndromes

scientific article (publication date: June 2006)

Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i

scientific article

Systematic re-evaluation of genes from candidate gene association studies in migraine using a large genome-wide association data set.

scientific article

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine

scientific article

The 3D Moore-Rayleigh test for the quantitative groupwise comparison of MR brain images

scientific article published in January 2009

The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation

scientific article

The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings

scientific article published on 30 May 2009

The first knockin mouse model of episodic ataxia type 2

scientific article

The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1).

scientific article

The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan

scientific article

Toward a molecular genetic classification of familial hemiplegic migraine

scientific article published on June 2004

Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine

scientific article

Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3

scientific article published on 29 October 2019

Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage

scientific article published on 27 December 2016

cATR Tracing Approach to Identify Individual Intermediary Neurons Based on Their Input and Output: A Proof-of-Concept Study Connecting Cerebellum and Central Hubs Implicated in Developmental Disorders

scientific article published in 2022

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