List of works - Jayakrishnan Nandakumar

A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes.

scientific article

Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D

scholarly article

Combining conservation and species-specific differences to determine how human telomerase binds telomeres

scientific article published on 10 December 2019

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe

scientific article

Dissecting the telomere-inner nuclear membrane interface formed in meiosis.

scientific article published on 30 October 2017

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

scientific article published on 17 September 2021

Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2.

scientific article published on 25 April 2005

Finding the end: recruitment of telomerase to telomeres

scientific article

Functional interaction between telomere protein TPP1 and telomerase

scientific article

How an RNA ligase discriminates RNA versus DNA damage

scientific article published in October 2004

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA

scientific article

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.

scientific article

Human POT1 protects the telomeric ds-ss DNA junction by capping the 5′ end of the chromosome

scientific article published on 17 August 2023

Inhibition of telomerase recruitment and cancer cell death

scientific article

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.

scientific article

RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward

scientific article published on 01 October 2006

RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2.

scientific article published on 13 April 2004

Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme

scientific article published on 8 May 2007

Structural and functional consequences of a disease mutation in the telomere protein TPP1.

scientific article

Structural basis for nick recognition by a minimal pluripotent DNA ligase

scientific article

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

scientific article published on 28 April 2020

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

scientific article

The shelterin complex and hematopoiesis.

scientific article published on 2 May 2016

List of works by Jayakrishnan Nandakumar

A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes.

Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D

Combining conservation and species-specific differences to determine how human telomerase binds telomeres

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe

Dissecting the telomere-inner nuclear membrane interface formed in meiosis.

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2.

Finding the end: recruitment of telomerase to telomeres

Functional interaction between telomere protein TPP1 and telomerase

How an RNA ligase discriminates RNA versus DNA damage

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.

Human POT1 protects the telomeric ds-ss DNA junction by capping the 5′ end of the chromosome

Inhibition of telomerase recruitment and cancer cell death

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.

RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward

RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2.

Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme

Structural and functional consequences of a disease mutation in the telomere protein TPP1.

Structural basis for nick recognition by a minimal pluripotent DNA ligase

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

The shelterin complex and hematopoiesis.