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List of works by Andrew W. Trafford

2,3-Butanedione monoxime (BDM) decreases sarcoplasmic reticulum Ca content by stimulating Ca release in isolated rat ventricular myocytes

scientific article published on 01 October 1998

A functional role for transverse (t-) tubules in the atria

scientific article

A measurable reduction of s.r. Ca content follows spontaneous Ca release in rat ventricular myocytes

scientific article published on 01 November 1997

A mechanism distinct from the L-type Ca current or Na–Ca exchange contributes to Ca entry in rat ventricular myocytes

scientific article published on 24 March 2006

A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.

scientific article

A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes

scientific article published on 01 February 1999

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged

scientific article published on 30 March 2012

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

scientific article published on 31 March 2022

Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart.

scientific article published on 16 May 2007

Author Correction: Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

correction of a scholarly article

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

scientific article

Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content

scientific article published on 17 January 2011

Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes

scientific article published on 01 April 1998

Calcium flux balance in the heart

scientific article published on 05 December 2012

Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias

scientific article

Can changes of ryanodine receptor expression affect cardiac contractility?

scientific article published on 01 March 2000

Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes.

scientific article published on 8 August 2011

Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure

scientific article published on 29 July 2009

Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling

scientific article published on 01 January 2020

Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)

scientific article

Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.

scientific article

Differences in intracellular calcium homeostasis between atrial and ventricular myocytes

scientific article published on 14 November 2008

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

scientific article

Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

scientific article published in 2021

Enhanced sarcolemmal Ca2+ efflux reduces sarcoplasmic reticulum Ca2+ content and systolic Ca2+ in cardiac hypertrophy

scientific article published in June 2004

Extracellular matrix profiles in the progression to heart failure. European Young Physiologists Symposium Keynote Lecture-Bratislava 2007.

scientific article published on 28 June 2008

Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes

scientific article published on 01 October 1993

From the ryanodine receptor to cardiac arrhythmias.

scientific article published on 10 August 2009

Heart failure and the ryanodine receptor: does Occam's razor rule?

scientific article published in November 2002

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

scientific article

How does CaMKIIdelta phosphorylation of the cardiac ryanodine receptor contribute to inotropy?

scientific article published on 21 July 2010

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

scientific article

Illuminating Sarcoplasmic Reticulum Calcium

scientific article published on 01 July 2003

Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure

article by Sarah J Briston et al published 15 March 2011 in Journal of Physiology

In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves

scientific article

Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes

scientific article published on 28 July 2017

Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves

scientific article published on 16 November 2006

Keeping the beat: life without SERCA--is it possible?

scientific article

Life, sudden death, and intracellular calcium.

scientific article published in August 2006

Localised micro-mechanical stiffening in the ageing aorta.

scientific article

Location, location, location: new avenues to determine the function of the cardiac Na+–Ca2+ exchanger? ⬇️

scientific article published on 01 November 2003

MAPS; acute safety data of the St Jude accent - tendril IPG system during prolonged max power CMR scanning.

scientific article published on 3 February 2015

Measurement of sarcoplasmic reticulum Ca2+content and sarcolemmal Ca2+fluxes in isolated rat ventricular myocytes during spontaneous Ca2+release

scientific article published on 01 May 1997

Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium

scientific article published on 01 December 2004

Na/Ca exchange: regulator of intracellular calcium and source of arrhythmias in the heart.

scientific article published on March 2007

No role for a voltage sensitive release mechanism in cardiac muscle

scientific article published in February 2003

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

scientific article published on 01 May 2019

Photoperiod-dependent modulation of cardiac excitation contraction coupling in the Siberian hamster.

scientific article published on 4 November 2004

Physiological and pathological modulation of ryanodine receptor function in cardiac muscle.

scientific article published on June 2004

Primum non nocere: when will ryanodine receptor leak find its role in heart failure?

scientific article

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

scientific article published on 17 December 2009

Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes.

scientific article published on 13 April 2006

Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i

scientific article published on 11 October 2007

Sarcoplasmic reticulum Ca-ATPase and heart failure 20 years later

scientific article published on September 2013

Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure

scientific article published on 27 October 2006

Stability and instability of regulation of intracellular calcium.

scientific article

Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca.

scientific article published in March 1998

The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation.

scientific article published in June 1998

The control of sarcoplasmic reticulum Ca content in cardiac muscle.

scientific article

The devil is in the details: methodological reviews - a new JMCC initiative

scientific article published on 01 June 2011

The effect of acidosis on systolic Ca2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes

scientific article published on 01 December 2000

The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes

scientific article published on 01 October 2000

The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate.

scientific article published on 06 March 2009

The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes

scientific article published in April 2001

The ryanodine receptor: cause or consequence of diabetic heart failure?

scientific article published in July 2000

The sarcoplasmic reticulum and arrhythmogenic calcium release

scientific article published on 13 September 2007

Three-dimensional reconstruction of cardiac sarcoplasmic reticulum reveals a continuous network linking transverse-tubules: this organization is perturbed in heart failure

scientific article published on 17 September 2013

Tissue section AFM: In situ ultrastructural imaging of native biomolecules

scientific article

Transverse tubules are a common feature in large mammalian atrial myocytes including human.

scientific article published on 12 August 2011

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