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List of works by Mark J. Crabtree

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice

scientific article published on 27 January 2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

scientific article published on 16 January 2017

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization

scientific article published on 21 August 2013

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

scientific journal article

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation

scientific article published on 26 November 2007

CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension.

scientific article published on 27 April 2015

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

scientific article published on 12 July 2012

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation

scientific article published on 28 April 2014

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

scientific article

Dihydrofolate reductase and biopterin recycling in cardiovascular disease

scientific article published on 30 September 2009

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

scientific article published on 12 March 2011

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification

scientific article

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection

scientific article

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice

scientific article published on 27 January 2012

Endothelin-1 increases superoxide production in human coronary artery bypass grafts

scientific article published on 28 March 2012

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression

scientific article published on 13 March 2009

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

scientific article published on 13 July 2021

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling

scientific article published on 8 November 2012

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases

scientific article published in September 2003

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

scientific article published in February 2016

Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen

scientific article published in September 2004

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

scientific article published on 01 July 2019

Nitric oxide synthases in heart failure

scientific article

Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine.

scientific article published in December 2007

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock

scientific article

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers

scientific article published on 14 November 2014

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen

scientific article published on 11 December 2003

Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase

scientific article published on 31 August 2007

Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.

scientific article published on 11 January 2016

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression

scientific article

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.

scientific article published on 11 January 2008

Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling ⬇️

scientific article published on September 1, 2012

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

scientific article

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

scientific article published in Nature Communications

Roles for Endothelial Cell and Macrophage Gch1 and Tetrahydrobiopterin in Atherosclerosis Progression ⬇️

scientific article published on 27 March 2018

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease ⬇️

scientific article published on April 22, 2011

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

scientific article

Systemic oxidative stress associated with lung resection during single lung ventilation

scientific article published on 20 July 2006

Targeting Vascular Redox Biology Through Antioxidant Gene Delivery: A Historical View and Current Perspectives ⬇️

scientific article published on 01 May 2011

Tetrahydrobiopterin in cardiovascular health and disease

scientific article

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

scientific article published in Scientific Reports

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

scientific article published on 6 May 2010

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

scientific article published on 19 October 2013

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