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List of works by Helena C Castro

3D-QSAR CoMFA of a series of DABO derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors

scientific article published in August 2008

4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease.

scientific article published in November 2012

Aminomethylnaphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals.

scientific article published on 25 February 2016

Antileishmanial Thioureas: Synthesis, Biological Activity and in Silico Evaluations of New Promising Derivatives

scientific article

Antiplatelet activity and structure-activity relationship study of Pyrazolopyridine Derivatives as potential series for treating thrombotic diseases.

scientific article published on 2 June 2010

Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

scientific article published in May 2003

Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization

scientific article published on 22 March 2016

Application of 4D-QSAR studies to a series of raloxifene analogs and design of potential selective estrogen receptor modulators.

scientific article published on 15 June 2012

Arylboronic acids inhibit P2X7 receptor function and the acute inflammatory response

scientific article published on 29 June 2019

Assessment of predictivity of volatile organic compounds carcinogenicity and mutagenicity by freeware in silico models

scientific article published on 29 September 2017

Bioequivalence studies and sugar-based excipients effects on the properties of new generic ketoconazole tablets formulations and stability evaluation by using direct compression method.

scientific article published in January 2009

Biotechnology: a non-existing word/world for the Brazilian deaf community

article

Bothroalternin, a thrombin inhibitor from the venom of Bothrops alternatus

scientific article published on 01 December 1998

Brown seaweed defensive chemicals: a structure-activity relationship approach for the marine environment

scientific article

COVID-19: don't forget deaf people

scientific article published on 01 March 2020

COVID-19: innovative antiviral drugs required for long-term prevention and control of coronavirus diseases

scientific article published on 27 October 2020

Cloning, characterization, and structural analysis of a C-type lectin from Bothrops insularis (BiL) venom

scientific article

Comparative analysis of viperidae venoms antibacterial profile: a short communication for proteomics.

scientific article

Comparative evaluation of immunological and structural similarities of snake venom C-type lectin proteins

scientific article published on 01 March 2003

Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease.

scientific article

DNA methylation: A promising target for the twenty-first century

scientific article published on 01 August 2008

Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives

scientific article published on 14 June 2006

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment.

scientific article published on 25 January 2016

Development and characterization of a new oral dapsone nanoemulsion system: permeability and in silico bioavailability studies

scientific article published on 28 September 2012

Development and validation of a HPLC-UV method for the determination in didanosine tablets

scientific article published in July 2005

Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties

scientific article published on 16 April 2011

Ecotin modulates thrombin activity through exosite-2 interactions.

scientific article

Ecotin: Exploring a feasible antithrombotic profile

scientific article published on 13 April 2015

Effect of 9-hydroxy-α- and 7-hydroxy-β-pyran naphthoquinones on Trypanosoma cruzi and structure-activity relationship studies

scientific article published on January 2014

Engineering ecotin for identifying proteins with a trypsin fold.

scientific article

Exploring N-Acylhydrazone Derivatives Against Clinical Resistant Bacterial Strains

scientific article published on 08 May 2014

Expression of B7-1 costimulatory molecules in patients with multibacillary leprosy and reactional states

scientific article published on 01 January 2007

Genetic Tests for Autism: The Challenges in the Laboratory Diagnosis

scientific article published on 07 June 2019

HIV-1 reverse transcriptase: a therapeutical target in the spotlight.

scientific article

Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile

scientific article published on 21 November 2017

Hologram QSAR models of 4-[(diethylamino)methyl]-phenol inhibitors of acetyl/butyrylcholinesterase enzymes as potential anti-Alzheimer agents.

scientific article published on 9 August 2012

Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme.

scientific article

Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel

scientific article published on 5 August 2013

Identification of Bothrojaracin-like proteins in snake venoms from Bothrops species and Lachesis muta

article

Identification of Nor-β-Lapachone Derivatives as Potential Antibacterial Compounds against Enterococcus faecalis Clinical Strain

scientific article published on 30 September 2010

Identification of a potential lead structure for designing new antimicrobials to treat infections caused by Staphylococcus epidermidis-resistant strains.

scientific article published on 23 September 2008

In Vitro–In Vivo Correlation of Efavirenz Tablets Using GastroPlus® ⬇️

scientific article published on August 14, 2013

In silico structural characteristics and α-amylase inhibitory properties of Ric c 1 and Ric c 3, allergenic 2S albumins from Ricinus communis seeds.

scientific article published on 5 April 2011

In vitro and in vivo analysis of the antithrombotic and toxicological profile of new antiplatelets N-acylhydrazone derivatives and development of nanosystems: determination of novel NAH derivatives antiplatelet and nanotechnological approach

scientific article published on 14 May 2014

Infection of Mouse Dermal Fibroblasts by the Monoxenous Trypanosomatid Protozoa Crithidia deanei and Herpetomonas roitmani

scientific article published on 01 September 2004

Influence of the efavirenz micronization on tableting and dissolution. ⬇️

scientific article published on 12 September 2012

Integrin inhibitors from snake venom: exploring the relationship between the structure and activity of RGD-peptides

scientific article

Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: new frontiers in the cellular immunology of leprosy.

scientific article

Isolation and molecular characterization of a major hemolymph serpin from the triatomine, Panstrongylus megistus

scientific article published on 14 January 2014

Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.

scientific article published on 23 July 2009

Looking at the proteases from a simple perspective.

scientific article published on March 2011

Molecular Cloning and Expression of Bothrojaracin, A Potent Thrombin Inhibitor from Snake Venom

scientific article published on 01 September 1997

Molecular Modeling of a Phenyl-Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl-Amidine Derivatives

scientific article published on 17 December 2012

Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi trypanothione reductase

scientific article published on 31 August 2009

Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase.

scientific article

Molecular modeling studies of the structural, electronic, and UV absorption properties of benzophenone derivatives.

scientific article

Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.

scientific article

Ornithobacterium rhinotracheale: An Update Review about An Emerging Poultry Pathogen

scientific article published on 27 December 2019

Oxoquinoline derivatives: identification and structure-activity relationship (SAR) analysis of new anti-HSV-1 agents.

scientific article published on 12 January 2011

Perceptions and Feelings of Brazilian Health Care Professionals Regarding the Effects of COVID-19: Cross-sectional Web-Based Survey

scientific article published on 22 October 2021

Platelets: still a therapeutical target for haemostatic disorders

scientific article

Preparation and evaluation of a new nano pharmaceutical excipients and drug delivery system based in polyvinylpyrrolidone and silicate

scientific article published on 01 January 2011

Preparation and evaluation of inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites: performance and substantivity studies

scientific article published in May 2008

Preparation of Dry Extract of Mikania glomerata Sprengel (Guaco) and Determination of Its Coumarin Levels by Spectrophotometry and HPLC-UV

scientific article published on 29 August 2012

Proteolytic action of Bothrops jararaca venom upon its own constituents.

scientific article

Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE).

scientific article published on 15 October 2010

Receptor-dependent 4D-QSAR analysis of peptidemimetic inhibitors of Trypanosoma cruzi trypanothione reductase with receptor-based alignment.

scientific article published on 20 February 2012

Residue-ligand interaction energy (ReLIE) on a receptor-dependent 3D-QSAR analysis of S- and NH-DABOs as non-nucleoside reverse transcriptase inhibitors.

scientific article published on 25 June 2012

Role of the undergraduate student research assistant in the new millennium.

scientific article published on January 2004

Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds

scientific article published on 08 December 2016

Snake Venom: Any Clue for Antibiotics and CAM?

scientific article

Sodium montmorillonite/amine-containing drugs complexes: new insights on intercalated drugs arrangement into layered carrier material

scientific article

Solving an ethical issue involved in experimentation with animals in a brazilian teaching laboratory*.

scientific article published on November 2004

Structural and pharmacological features of phospholipases A2 from snake venoms.

scientific article published on January 2009

Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?

scientific article published in June 2001

Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure-activity relationship study and analysis of interactions.

scientific article published on 12 March 2013

Structure-function inferences based on molecular modeling, sequence-based methods and biological data analysis of snake venom lectins

scientific article

Subunit dissociation, unfolding, and inactivation of bothrojaracin, a C-type lectin-like protein from snake venom

scientific article published in January 2003

Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening

scientific article published on 01 October 2012

Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones.

scientific article published on 3 February 2011

Synthesis and antiplatelet activity of antithrombotic thiourea compounds: biological and structure-activity relationship studies.

scientific article published on 20 April 2015

Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents

scientific article

Synthesis using microwave irradiation and antibacterial evaluation of new N,O-acetals and N,S-acetals derived from 2-amino-1,4-naphthoquinones

scientific article published on 23 January 2013

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors

scientific article published on 30 April 2019

Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series.

scientific article published on 5 November 2008

Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides

scientific article published in April 2009

Synthesis, antitubercular activity, and SAR study of N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides

scientific article published on 24 July 2011

Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives

scientific article

Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom

scientific article published on 24 September 2009

Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs. ⬇️

scientific article

Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series

scientific article published on 01 October 2006

Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives

scholarly article by Marilia S. Costa et al published December 2006 in Bioorganic & Medicinal Chemistry

The study of vancomycin use and its adverse reactions associated to patients of a Brazilian university hospital.

scientific article

Therapeutic nanosystems for oral administration of insulin.

scientific article published on January 2014

Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure–activity relationship (SAR)

scientific article published on 21 June 2011

Trypanocidal agents with low cytotoxicity to mammalian cell line: a comparison of the theoretical and biological features of lapachone derivatives.

scientific article published on 24 May 2006

Trypanosoma cruzi: in vitro activity of Epoxy-alpha-Lap, a derivative of alpha-lapachone, on trypomastigote and amastigote forms

scientific article published on 11 March 2009

Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity

scientific article

Tuberculosis: Finding a New Potential Antimycobacterium Derivative in a Aldehyde–Arylhydrazone–Oxoquinoline Series

scientific article published on 08 July 2012

Two novel defensin-encoding genes of the Chagas disease vector Triatoma brasiliensis (Reduviidae, Triatominae): gene expression and peptide-structure modeling

scientific article published on 17 June 2009

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