List of works - Marko D. Mihovilovic

A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan

scientific article published on 08 July 2019

Accessing tetrahydrofuran-based natural products by microbial Baeyer-Villiger biooxidation

scientific article published on 19 June 2006

Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility

scientific article published on 24 February 2020

Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives.

scientific article

Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

scientific article published on 14 January 2011

Asymmetric Baeyer-Villiger oxidations of 4-mono- and 4,4-disubstituted cyclohexanones by whole cells of engineered Escherichia coli

scientific article

Asymmetric bioreduction of activated carbon-carbon double bonds using Shewanella yellow enzyme (SYE-4) as novel enoate reductase

scientific article published on September 2012

Author Correction: Opportunities and challenges for combining chemo- and biocatalysis

scholarly article

Baeyer-Villiger monooxygenases in aroma compound synthesis.

scientific article

Baeyer-Villiger oxidations: biotechnological approach.

scientific article published on 21 June 2016

Baker's Yeast-Mediated Reductions of alpha-Keto Esters and an alpha-Keto-beta-Lactam. Two Routes to the Paclitaxel Side Chain

scientific article published on 01 September 1999

Biocompatible metal-assisted C-C cross-coupling combined with biocatalytic chiral reductions in a concurrent tandem cascade

Biooxidation of bridged cycloketones using Baeyer-Villiger monooxygenases of various bacterial origin

scientific article

Cascade catalysis--strategies and challenges en route to preparative synthetic biology.

scientific article published on 05 February 2015

Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds.

scientific article published on 5 October 2017

Cloning and characterization of the Type I Baeyer-Villiger monooxygenase from Leptospira biflexa

scientific article

Construction of a xylanase A variant capable of polymerization

scientific article

Continuous testing system for Baeyer-Villiger biooxidation using recombinant Escherichia coli expressing cyclohexanone monooxygenase encapsulated in polyelectrolyte complex capsules.

scientific article

Corrigendum to "Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands" [Bioorg. Med. Chem. Lett. 25/2 (2015) 400-403].

scientific article published on 20 February 2015

Design and Synthesis of a Compound Library Exploiting 5-Methoxyleoligin as Potential Cholesterol Efflux Promoter

scientific article published on 04 February 2020

Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes

scientific article

Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.

scientific article

Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms

scientific article

Discovery and resupply of pharmacologically active plant-derived natural products: A review ⬇️

scientific article

Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

scientific article published on 03 May 2013

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project

scientific article

Efficient biooxidations catalyzed by a new generation of self-sufficient Baeyer-Villiger monooxygenases

scientific article published on 01 November 2009

Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives

scientific article

Efforts to induce cardiac electrophysiological properties in skeletal myoblasts in vitro.

scientific article published on 5 November 2008

Enantiocomplementary access to carba-analogs of C-nucleoside derivatives by recombinant Baeyer-Villiger monooxygenases.

scientific article published in March 2013

Enantioselective kinetic resolution of 3-phenyl-2-ketones using Baeyer–Villiger monooxygenases

Encapsulation of recombinant E. coli expressing cyclopentanone monooxygenase in polyelectrolyte complex capsules for Baeyer-Villiger biooxidation of 8-oxabicyclo[3.2.1]oct-6-en-3-one.

scientific article published on 29 January 2010

Enzymatic synthesis of enantiomerically pure beta-amino ketones, beta-amino esters, and beta-amino alcohols with Baeyer-Villiger monooxygenases

scientific article published in August 2010

Esters of valerenic acid as potential prodrugs.

scientific article

Exploiting the Regioselectivity of Baeyer-Villiger Monooxygenases for the Formation of β-Amino Acids and β-Amino Alcohols

scientific article published on 01 June 2010

Exploration of C-H and N-H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines

scientific article published on 15 September 2014

Extending the substrate scope of a Baeyer-Villiger monooxygenase by multiple-site mutagenesis.

scientific article

Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman

scientific article published on 22 October 2010

Family clustering of Baeyer-Villiger monooxygenases based on protein sequence and stereopreference

scientific article published on 01 June 2005

First chemo-enzymatic synthesis of the (R)-Taniguchi lactone and substrate profiles of CAMO and OTEMO, two new Baeyer-Villiger monooxygenases

scientific article published on 21 December 2016

First enantiodivergent Baeyer-Villiger oxidation by recombinant whole-cells expressing two monooxygenases from Brevibacterium.

scientific article published in April 2003

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C-H activation.

scientific article published on 3 April 2013

Fusion proteins of an enoate reductase and a Baeyer-Villiger monooxygenase facilitate the synthesis of chiral lactones.

scientific article published on 11 June 2016

Halogenated 2'-chlorobithiazoles via Pd-catalyzed cross-coupling reactions

scientific article published on 01 May 2006

Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface

scientific article published on May 2013

Immobilized Cell Physiology Imaging and Stabilization of Enzyme Cascade Reaction Using Recombinant Cells Escherichia coli Entrapped in Polyelectrolyte Complex Beads by Jet Break-Up Encapsulator

scientific article published in 2020

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.

scientific article published on 24 March 2016

In vitro characterization of an enzymatic redox cascade composed of an alcohol dehydrogenase, an enoate reductases and a Baeyer-Villiger monooxygenase

scientific article published on 16 April 2014

Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis - a novel transformation in carbohydrate chemistry

scientific article published on 01 October 2019

Investigation of a New Type I Baeyer-Villiger Monooxygenase from Amycolatopsis thermoflava Revealed High Thermodynamic but Limited Kinetic Stability

scientific article published on 09 January 2020

Investigations of the halogen dance reaction on N-substituted 2-thiazolamines.

scientific article published in January 2005

Kinetic Modeling of an Enzymatic Redox Cascade In Vivo Reveals Bottlenecks Caused by Cofactors

Kinetic resolution of aliphatic acyclic beta-hydroxyketones by recombinant whole-cell Baeyer-Villiger monooxygenases--formation of enantiocomplementary regioisomeric esters

scientific article

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

scientific article published on 24 May 2016

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

scientific article published on 14 May 2019

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation

scientific article

Magnolol dimer-derived fragments as PPARγ-selective probes

scientific article published on 01 October 2018

Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution.

scientific article published on 13 November 2017

Mechanistic and Kinetic Studies of the Direct Alkylation of Benzylic Amines: A Formal C(sp(3))-H Activation Proceeds Actually via a C(sp(2))-H Activation Pathway

scientific article published on 8 December 2014

Metal-assisted multicomponent reactions involving carbon monoxide--towards heterocycle synthesis

scientific article published on 01 January 2007

Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands

scientific article

Microbial Baeyer-Villiger oxidation of terpenones by recombinant whole-cell biocatalysts--formation of enantiocomplementary regioisomeric lactones.

scientific article published on 25 April 2007

Microbial Baeyer-Villiger oxidation: stereopreference and substrate acceptance of cyclohexanone monooxygenase mutants prepared by directed evolution

scientific article

Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes.

scientific article

Morpholine-based buffers activate aerobic photobiocatalysis spin correlated ion pair formation

scientific article published on 11 February 2019

Non-hazardous Baeyer-Villiger oxidation of levulinic acid derivatives: alternative renewable access to 3-hydroxypropionates

scientific article published on 01 February 2015

Non-hazardous biocatalytic oxidation in Nylon-9 monomer synthesis on a 40 g scale with efficient downstream processing

scientific article published on 14 April 2017

Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy.

scientific article published in June 2005

Opportunities and challenges for combining chemo- and biocatalysis

Palladium(II)-Catalyzed Regioselective Ortho Arylation of sp(2) C-H Bonds of N-Aryl-2-amino Pyridine Derivatives

scientific article published on 13 June 2012

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters.

scientific article published on 08 July 2016

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation

scientific article published on 01 July 2015

Recent Developments in the Application of Baeyer–Villiger Monooxygenases as Biocatalysts ⬇️

scientific article published on November 2, 2010

Recombinant whole-cell mediated baeyer-villiger oxidation of perhydropyran-type ketones.

scientific article

Regiodivergent Baeyer-Villiger oxidation of fused ketones by recombinant whole-cell biocatalysts

scientific article published in January 2008

Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv.

scientific article

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates

scientific article published on 26 March 2012

Ruthenium(II)-catalyzed sp3 C-H bond arylation of benzylic amines using aryl halides

scientific article published on 12 July 2012

Selective Ru(0)-catalyzed deuteration of electron-rich and electron-poor nitrogen-containing heterocycles

scientific article published on 24 April 2012

Self-sufficient Baeyer-Villiger monooxygenases: effective coenzyme regeneration for biooxygenation by fusion engineering

scientific article published in January 2008

Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells

scientific article

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

scientific article published on 31 July 2020

Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters

scientific article published on 02 February 2011

Synthesis of Enantiomerically Pure Bicyclo[4.2.0]octanes by Cu-Catalyzed [2+2] Photocycloaddition and Enantiotopos-Differentiating Ring Opening

scientific article published on 01 August 2006

Synthesis of an antiviral drug precursor from chitin using a saprophyte as a whole-cell catalyst.

scientific article

Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents.

scientific article

Synthesis of novel sterically demanding carbo- and heterocyclic beta-ketoesters

scientific article published on 10 May 2006

Synthesis of pyrrolo[2,3-d][1,2,3]thiadiazole-6-carboxylates via the Hurd-Mori reaction. Investigating the effect of the N-protecting group on the cyclization.

scientific article published on 28 February 2005

Tandem catalysis: from alkynoic acids and aryl iodides to 1,2,3-triazoles in one pot

scientific article published on 10 March 2011

Targeting aphA : a new high-throughput screening assay identifies compounds that reduce prime virulence factors of Vibrio cholerae.

scientific article published on 12 May 2016

Thiophene ring-fragmentation reactions: Principles and scale-up towards NLO materials

Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.

scientific article published on 26 September 2013

VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes.

scientific article published on August 2013

Variations on a scaffold - Novel GABAA receptor modulators

scientific article published on 05 July 2019

List of works by Marko D. Mihovilovic

A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan

Accessing tetrahydrofuran-based natural products by microbial Baeyer-Villiger biooxidation

Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility

Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives.

Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production

Asymmetric Baeyer-Villiger oxidations of 4-mono- and 4,4-disubstituted cyclohexanones by whole cells of engineered Escherichia coli

Asymmetric bioreduction of activated carbon-carbon double bonds using Shewanella yellow enzyme (SYE-4) as novel enoate reductase

Author Correction: Opportunities and challenges for combining chemo- and biocatalysis

Baeyer-Villiger monooxygenases in aroma compound synthesis.

Baeyer-Villiger oxidations: biotechnological approach.

Baker's Yeast-Mediated Reductions of alpha-Keto Esters and an alpha-Keto-beta-Lactam. Two Routes to the Paclitaxel Side Chain

Biocompatible metal-assisted C-C cross-coupling combined with biocatalytic chiral reductions in a concurrent tandem cascade

Biooxidation of bridged cycloketones using Baeyer-Villiger monooxygenases of various bacterial origin

Cascade catalysis--strategies and challenges en route to preparative synthetic biology.

Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds.

Cloning and characterization of the Type I Baeyer-Villiger monooxygenase from Leptospira biflexa

Construction of a xylanase A variant capable of polymerization

Continuous testing system for Baeyer-Villiger biooxidation using recombinant Escherichia coli expressing cyclohexanone monooxygenase encapsulated in polyelectrolyte complex capsules.

Corrigendum to "Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands" [Bioorg. Med. Chem. Lett. 25/2 (2015) 400-403].

Design and Synthesis of a Compound Library Exploiting 5-Methoxyleoligin as Potential Cholesterol Efflux Promoter

Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes

Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.

Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms

Discovery and resupply of pharmacologically active plant-derived natural products: A review ⬇️

Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project

Efficient biooxidations catalyzed by a new generation of self-sufficient Baeyer-Villiger monooxygenases

Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives

Efforts to induce cardiac electrophysiological properties in skeletal myoblasts in vitro.

Enantiocomplementary access to carba-analogs of C-nucleoside derivatives by recombinant Baeyer-Villiger monooxygenases.

Enantioselective kinetic resolution of 3-phenyl-2-ketones using Baeyer–Villiger monooxygenases

Encapsulation of recombinant E. coli expressing cyclopentanone monooxygenase in polyelectrolyte complex capsules for Baeyer-Villiger biooxidation of 8-oxabicyclo[3.2.1]oct-6-en-3-one.

Enzymatic synthesis of enantiomerically pure beta-amino ketones, beta-amino esters, and beta-amino alcohols with Baeyer-Villiger monooxygenases

Esters of valerenic acid as potential prodrugs.

Exploiting the Regioselectivity of Baeyer-Villiger Monooxygenases for the Formation of β-Amino Acids and β-Amino Alcohols

Exploration of C-H and N-H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines

Extending the substrate scope of a Baeyer-Villiger monooxygenase by multiple-site mutagenesis.

Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman

Family clustering of Baeyer-Villiger monooxygenases based on protein sequence and stereopreference

First chemo-enzymatic synthesis of the (R)-Taniguchi lactone and substrate profiles of CAMO and OTEMO, two new Baeyer-Villiger monooxygenases

First enantiodivergent Baeyer-Villiger oxidation by recombinant whole-cells expressing two monooxygenases from Brevibacterium.

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C-H activation.

Fusion proteins of an enoate reductase and a Baeyer-Villiger monooxygenase facilitate the synthesis of chiral lactones.

Halogenated 2'-chlorobithiazoles via Pd-catalyzed cross-coupling reactions

Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface

Immobilized Cell Physiology Imaging and Stabilization of Enzyme Cascade Reaction Using Recombinant Cells Escherichia coli Entrapped in Polyelectrolyte Complex Beads by Jet Break-Up Encapsulator

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.

In vitro characterization of an enzymatic redox cascade composed of an alcohol dehydrogenase, an enoate reductases and a Baeyer-Villiger monooxygenase

Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis - a novel transformation in carbohydrate chemistry

Investigation of a New Type I Baeyer-Villiger Monooxygenase from Amycolatopsis thermoflava Revealed High Thermodynamic but Limited Kinetic Stability

Investigations of the halogen dance reaction on N-substituted 2-thiazolamines.

Kinetic Modeling of an Enzymatic Redox Cascade In Vivo Reveals Bottlenecks Caused by Cofactors

Kinetic resolution of aliphatic acyclic beta-hydroxyketones by recombinant whole-cell Baeyer-Villiger monooxygenases--formation of enantiocomplementary regioisomeric esters

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation

Magnolol dimer-derived fragments as PPARγ-selective probes

Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution.

Mechanistic and Kinetic Studies of the Direct Alkylation of Benzylic Amines: A Formal C(sp(3))-H Activation Proceeds Actually via a C(sp(2))-H Activation Pathway

Metal-assisted multicomponent reactions involving carbon monoxide--towards heterocycle synthesis

Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands

Microbial Baeyer-Villiger oxidation of terpenones by recombinant whole-cell biocatalysts--formation of enantiocomplementary regioisomeric lactones.

Microbial Baeyer-Villiger oxidation: stereopreference and substrate acceptance of cyclohexanone monooxygenase mutants prepared by directed evolution

Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes.

Morpholine-based buffers activate aerobic photobiocatalysis spin correlated ion pair formation

Non-hazardous Baeyer-Villiger oxidation of levulinic acid derivatives: alternative renewable access to 3-hydroxypropionates

Non-hazardous biocatalytic oxidation in Nylon-9 monomer synthesis on a 40 g scale with efficient downstream processing

Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy.

Opportunities and challenges for combining chemo- and biocatalysis

Palladium(II)-Catalyzed Regioselective Ortho Arylation of sp(2) C-H Bonds of N-Aryl-2-amino Pyridine Derivatives

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters.

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation

Recent Developments in the Application of Baeyer–Villiger Monooxygenases as Biocatalysts ⬇️

Recombinant whole-cell mediated baeyer-villiger oxidation of perhydropyran-type ketones.

Regiodivergent Baeyer-Villiger oxidation of fused ketones by recombinant whole-cell biocatalysts

Resolution of fused bicyclic ketones by a recombinant biocatalyst expressing the Baeyer-Villiger monooxygenase gene Rv3049c from Mycobacterium tuberculosis H37Rv.

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates

Ruthenium(II)-catalyzed sp3 C-H bond arylation of benzylic amines using aryl halides

Selective Ru(0)-catalyzed deuteration of electron-rich and electron-poor nitrogen-containing heterocycles