List of works - Fred van Leuven

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease

scientific article

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

scientific article

Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders

scientific article

Alzheimer's disease: old problem, new views from transgenic and viral models

scientific article published on 21 March 2010

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

scientific article

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

scientific article

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease

scientific article published on 6 January 2011

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

scientific article

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

scientific article published on 10 March 2008

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

scientific journal article

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

scientific article

Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration

scientific article

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy

scientific article published on 03 February 2014

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

scientific article

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

scientific article

GSK3 and Alzheimer’s disease: facts and fiction… ⬇️

scientific article published on August 26, 2011

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein ⬇️

scientific article published on August 27, 2012

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

scientific article published on May 2012

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease

scientific article

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

scientific article (publication date: 2013)

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

scientific journal article

Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease

scientific article published on 24 August 2010

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

scientific article

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

scientific article

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

scientific article published on 25 May 2013

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

scientific article

Neuropathobiology in transgenic mice. The case of Alzheimer's disease.

scientific article

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

scientific article published on 30 December 2016

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

scientific article

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model ⬇️

scientific article published on September 2, 2010

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease

scientific article published on June 2016

Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease

scientific article

Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease ⬇️

scientific article published on June 8, 2012

Protein folding diseases and neurodegeneration: lessons learned from yeast

scientific article published on 11 February 2008

Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

scientific article

Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice

scientific article published on July 2002

Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo ⬇️

scientific article published on October 24, 2011

Secretases as targets for the treatment of Alzheimer's disease: the prospects

scientific article

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

scientific article

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

scientific article

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study

scientific article

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare

scientific article

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

scholarly article

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

scientific article

List of works by Fred van Leuven

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders

Alzheimer's disease: old problem, new views from transgenic and viral models

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

GSK3 and Alzheimer’s disease: facts and fiction… ⬇️

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein ⬇️

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

Neuropathobiology in transgenic mice. The case of Alzheimer's disease.

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model ⬇️

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease

Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease

Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease ⬇️

Protein folding diseases and neurodegeneration: lessons learned from yeast

Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice

Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo ⬇️

Secretases as targets for the treatment of Alzheimer's disease: the prospects

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice