List of works - Ilse Dewachter

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

scientific article

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

scientific article

APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation

scientific article published on 30 December 2015

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

scientific article published on 27 January 2016

Alzheimer's disease: old problem, new views from transgenic and viral models

scientific article published on 21 March 2010

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

scientific article

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

scientific article published on April 2013

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

scientific article

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

scientific article

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

scientific article published on 10 March 2008

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

scientific journal article

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

scientific article published on 23 March 2017

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

scientific article

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

scientific article

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

scientific article published on 10 May 2016

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

scientific article published on 6 January 2016

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

scientific article

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

scientific article published on 25 May 2013

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

scientific article

Neuropathobiology in transgenic mice. The case of Alzheimer's disease.

scientific article

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

scientific article published on October 2003

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

scientific article

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

scientific article

Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

scientific article

Secretases as targets for the treatment of Alzheimer's disease: the prospects

scientific article

Tau association with synaptic vesicles causes presynaptic dysfunction

scientific article

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

scientific article

Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease

scientific article published on 6 March 2014

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

scientific article published on 11 April 2015

The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil

scientific article

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

scholarly article

Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects.

scientific article

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

scientific article

List of works by Ilse Dewachter

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

Alzheimer's disease: old problem, new views from transgenic and viral models

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

Neuropathobiology in transgenic mice. The case of Alzheimer's disease.

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

Secretases as targets for the treatment of Alzheimer's disease: the prospects

Tau association with synaptic vesicles causes presynaptic dysfunction

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects.

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice