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List of works by R Largo

6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity

scientific article published on 30 August 2013

A fibrin based model for rheumatoid synovitis.

scientific article published on December 2003

A subgroup of lupus patients with nephritis, innate T cell activation and low vitamin D is identified by the enhancement of circulating MHC class I-related chain A

scientific article published on 27 February 2019

ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis

scientific article published on 01 December 1995

Activation of NF-kappaB in tubular epithelial cells of rats with intense proteinuria: role of angiotensin II and endothelin-1.

scientific article published on April 2001

An OA phenotype may obtain major benefit from bone-acting agents

scientific article published on 07 September 2013

An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis

scientific article published on 01 September 1996

An update on the up and coming therapies to treat osteoarthritis, a multifaceted disease.

scientific article published on 21 June 2016

Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria

scientific article published on 01 February 1999

Aromatase expression in human chondrocytes: An induction due to culture

scientific article published on 07 December 2015

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

scientific article published on 01 May 2008

Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis.

scientific article published on 7 July 2011

Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits

scientific article published on 25 October 2005

Characterization of a new experimental model of osteoporosis in rabbits

scientific article

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.

scientific article published on 27 August 2015

Chondrocyte enlargement is a marker of osteoarthritis severity

scientific article published on 30 April 2019

Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis

scientific article published on 28 April 2010

Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: a novel model of atherosclerosis associated with chronic inflammation

scientific article published in September 2008

Científicos españoles con los Dres. Greg Winter y Richard A. Lerner, premios Príncipe de Asturias en Investigación Científica y Técnica 2012

article

Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Plac

scientific article published on 31 July 2016

Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis.

scientific article

Corrigendum: The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction

scientific article published on 19 August 2016

Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

scientific article published on 28 September 2020

DXA in the assessment of subchondral bone mineral density in knee osteoarthritis--A semi-standardized protocol after systematic review

scientific article published on 19 June 2015

Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.

scientific article

Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes.

scientific article

Does oral glucosamine prevent subchondral bone loss in an animal model of osteoarthritis? Comment on the article by Wang et al.

scientific article published in February 2008

EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts.

scientific article published on October 2004

Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis.

scientific article published in May 2009

Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth

scientific article published on 01 April 1996

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis

scientific article published on 27 August 2012

Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits

scientific article published on 01 June 2010

Endothelin-1 expression during early response after antigen challenge in brown-norway rats

scientific article published on 01 April 1998

Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril

scientific article published on 01 May 1997

Expression of the peptide C4b-binding protein beta in the arthritic joint

scientific article published on 5 May 2006

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

scientific article published in 2022

Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis

scientific article published on 01 January 2003

Glomerular up-regulation of EIIIA and V120 fibronectin isoforms in proliferative immune complex nephritis

scientific article published on 01 September 1996

Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?

scientific article published on 18 June 2020

Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes

scientific article published in April 2003

Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis

scientific article published on 01 November 2004

Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration

scientific article published on 13 August 2013

Improvement of experimental accelerated atherosclerosis by chondroitin sulphate.

scientific article published on 24 April 2010

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis.

scientific article published on 23 July 2011

Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

scientific article published in December 2017

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

scientific article published on 29 January 2019

Interaction of intimal fibroblasts with intracavitary fibrin: a morphologic follow up in ovalbumin arthritis.

scientific article published on 4 February 2002

Is lecturing in Rheumatology Satellite Symposia a male attribute?

scientific article

Lipid transport and metabolism in healthy and osteoarthritic cartilage

scientific article published on 16 October 2013

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis

scientific article

Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation.

scientific article

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure

scientific article

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition

scientific article published in July 2001

Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.

scientific article published in February 2010

O-linked N-acetylglucosamine (O-GlcNAc) protein modification is increased in the cartilage of patients with knee osteoarthritis.

scientific article published on 12 December 2013

Osteoarthritis: Chondroitin sulfate - CONCEPT clear, uncertainties unchanged

scientific article published on 17 August 2017

Osteoarthritis: a progressive disease with changing phenotypes.

scientific article published on 22 July 2013

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits

scientific article published on 24 July 2006

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

scientific article published on 19 December 2015

PTH increases jaw mineral density in a rabbit model of osteoporosis

scientific article

Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains.

scientific article published in January 2018

Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta

scientific article published on 01 August 1997

Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha

scientific article published on 31 March 2007

Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis

scientific article published on 01 May 1997

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

scientific article

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

scientific article published in Nature Communications

Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage

scientific article published on 01 January 1999

Reply

scientific article published on 29 August 2017

SDF-1 signaling: a promising target in rheumatic diseases

scientific article

Selective estrogen receptor modulators (SERMs): new alternatives for osteoarthritis?

scientific article published on 15 February 2014

Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis

scientific article published on August 2004

Studies of piroxicam absorption by oral mucosa.

scientific article published in January 2002

Subchondral bone as a key target for osteoarthritis treatment.

scientific article published on 22 September 2011

Subchondral bone remodelling and osteoarthritis

scientific article

TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.

scientific article

Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression

scientific article published on 27 February 2019

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

scientific article published on 05 December 2018

Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice

scientific article published on 25 February 2019

The Increase in O-Linked N-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Both in Vitro and in Vivo ⬇️

scientific article published on August 2, 2012

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.

scientific article published on 07 July 2016

The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits

scientific article published on 11 November 2016

Tight blood pressure control decreases apoptosis during renal damage

scientific article published in March 2004

Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis

scientific article published on 23 June 2017

Treating osteoporotic osteoarthritis, or the art of cutting a balding man's hair

scientific article published on 18 December 2019

Unexpected Bone Formation Produced by RANKL Blockade.

scientific article

Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure

scientific article

Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis

scientific article published on 24 April 2018

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