List of works - Annamaria De Luca

"The Social Network" and Muscular Dystrophies: The Lesson Learnt about the Niche Environment as a Target for Therapeutic Strategies

scientific article published on 09 July 2020

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

scientific article

A stereospecific binding site regulates the C1− ion channel in rat skeletal muscle

scientific article published on 01 December 1988

Aging and chloride channel regulation in rat fast-twitch muscle fibres

scientific article published on 01 May 1994

Aging-associated down-regulation of ClC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance

scientific article published on 01 April 1999

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

scientific article published on 30 May 2013

Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase

scientific article

Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats

scientific article published on 01 March 2000

Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone

scientific article published on 27 February 2016

Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.

scientific article published in October 2001

Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids

scientific article published in March 2001

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

scientific article

Changes of chloride channel regulation in rat skeletal muscle during aging

scientific article published in December 1992

Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice

scientific article published on 01 October 1995

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

scientific article published on January 2013

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

scientific article

Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points

scientific article published on 5 January 2017

Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse

scientific article published on 6 May 2011

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

scientific article published on 15 August 2003

Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide.

scientific article published in October 1996

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

scientific article

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

scientific article

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

scientific article

Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions.

scientific article published on 10 October 2006

Effect of exercise on telomere length and telomere proteins expression in mdx mice

scientific article published on 23 May 2020

Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia

scientific article published on 01 May 1999

Effect of taurine depletion on excitation-contraction coupling and C1− conductance of rat skeletal muscle

scientific article published on 01 January 1996

Effects of HMG-CoA reductase inhibitors on excitation–contraction coupling of rat skeletal muscle

scientific article published on 01 January 1999

Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation

scientific article (publication date: 2015)

Effects of aging on the mechanical threshold of rat skeletal muscle fibers

scientific article published on 01 March 1992

Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice

scientific article published on 25 March 2013

Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation.

scientific article

Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

scientific article published on 13 June 2011

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

scientific article

Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice

scientific article published on 6 July 2011

Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise

scientific article published on 30 July 2020

Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy.

scientific article published in April 2011

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

scientific article

First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant

scientific article published on 15 March 2006

GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy

scientific article published on 22 March 2013

Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical-metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy

scientific article published on 10 June 2014

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

scientific article published on 23 July 2008

Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse

scientific article

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

scientific article

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

scientific article published on 10 March 2017

Higher content of insulin-like growth factor-I in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function

scientific article published on 01 January 1999

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

scientific article

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)

scientific article published on 07 February 2020

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

scientific article published on November 1999

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

scientific article

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

scientific article published on 12 October 2016

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

scientific article published in January 2004

Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy

article

Isolation and characterization of neural stem cells from dystrophic mdx mouse.

scientific article published on 22 March 2016

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

scientific article

Membrane ionic conductances in normal and denervated skeletal muscle of the rat during development

article

Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres

scientific article published in August 1998

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

scientific article

Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests.

scientific article published on 8 January 2009

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

scientific article

Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse.

scientific article published on 17 April 2009

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

scientific article

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

scientific article published in November 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

scientific article published in October 2003

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

scientific article published on 28 September 2006

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

scientific article

Pharmacological Interventions for the Changes of Chloride Channel Conductance of Aging Rat Skeletal Musclea

scientific article published on 01 June 1994

Pharmacological block of chloride channels of developing rat skeletal muscle affects the differentiation of specific contractile properties

scientific article published on 01 April 1990

Pharmacology of CLC Chloride Channels and Transporters

scholarly article by Michael Pusch et al published 2006 in Advances in Molecular and Cell Biology

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

scientific article

Prednisone in dystrophin-deficient Caernorabditis elegans

scientific article published in October 2004

Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ.

scientific article published on 20 March 2014

Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds

scientific article

Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile

scientific article published on 01 March 2005

Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach

scientific article published in June 2007

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

scientific article

Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy.

scientific article published on July 2016

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin.

scientific article published in July 2016

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

scientific article

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

scientific article published on August 2003

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

scientific article published in March 2010

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

scientific article

Taurine and skeletal muscle disorders

scientific article published on January 2004

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

scientific article

The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo

scientific article published in November 2004

Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery

scientific article

Therapeutic screening in the mdx mouse.

scientific article

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

scientific article published on 9 April 2008

β-Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation

scientific article published on 23 November 2021

List of works by Annamaria De Luca

"The Social Network" and Muscular Dystrophies: The Lesson Learnt about the Niche Environment as a Target for Therapeutic Strategies

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

A stereospecific binding site regulates the C1− ion channel in rat skeletal muscle

Aging and chloride channel regulation in rat fast-twitch muscle fibres

Aging-associated down-regulation of ClC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase

Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats

Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone

Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.

Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Changes of chloride channel regulation in rat skeletal muscle during aging

Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points

Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide.

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions.

Effect of exercise on telomere length and telomere proteins expression in mdx mice

Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia

Effect of taurine depletion on excitation-contraction coupling and C1− conductance of rat skeletal muscle

Effects of HMG-CoA reductase inhibitors on excitation–contraction coupling of rat skeletal muscle

Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation

Effects of aging on the mechanical threshold of rat skeletal muscle fibers

Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice

Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation.

Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice

Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise

Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy.

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant

GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy

Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical-metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

Higher content of insulin-like growth factor-I in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy

Isolation and characterization of neural stem cells from dystrophic mdx mouse.

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

Membrane ionic conductances in normal and denervated skeletal muscle of the rat during development

Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests.

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse.

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

Pharmacological Interventions for the Changes of Chloride Channel Conductance of Aging Rat Skeletal Musclea

Pharmacological block of chloride channels of developing rat skeletal muscle affects the differentiation of specific contractile properties

Pharmacology of CLC Chloride Channels and Transporters

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

Prednisone in dystrophin-deficient Caernorabditis elegans

Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ.

Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds

Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile

Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy.