List of works by Eoin P Cummins

A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network

article

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

scientific article published on 6 February 2013

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.

scientific article published on 6 July 2015

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.

scientific article published on 13 December 2010

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

scientific article published on 15 May 2017

Carbon dioxide-sensing in organisms and its implications for human disease.

scientific article published on 18 September 2013

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

scientific article published on 03 December 2019

Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability

scientific article published on 04 June 2007

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

scientific journal article

Gremlin plays a key role in the pathogenesis of pulmonary hypertension

scientific article

HIF-2α - a mediator of stem cell altruism?

scientific article published on 18 December 2012

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes

scientific article published on 30 January 2019

Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].

scientific article published on 27 October 2016

Hydroxylases as therapeutic targets in inflammatory bowel disease.

scientific article published on 18 February 2013

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

scientific article published on 04 April 2016

Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.

scientific article published on 6 March 2012

Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway

scientific article published on September 2009

Hypoxia and inflammatory bowel disease.

scientific article published on 20 September 2016

Hypoxia-dependent regulation of inflammatory pathways in immune cells

scientific article

Hypoxia-responsive transcription factors.

scientific article

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function

scientific article published on 30 June 2010

Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals

scientific article published on 20 September 2019

MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia

scientific article published on August 2011

NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells

scientific article published on 3 September 2010

PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

scholarly article

Physiological gases in health and disease - key regulatory factors, not just a lot of hot air.

scientific article published in April 2017

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

scientific article published on 26 April 2016

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

scientific article published on 26 April 2019

REST is a hypoxia-responsive transcriptional repressor

scientific article

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.

scientific article published on 9 December 2015

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

scientific article published on 21 October 2013

Regulation of gene expression by carbon dioxide

scientific article (publication date: 15 February 2011)

Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism

scientific article published in October 2006

Respiratory gases and the regulation of transcription.

scientific article

Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia

scientific article published on December 2010

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

scientific article

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

scientific article published on 16 September 2015

The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells

scientific article

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

scientific article published on 10 October 2007

The role of HIF in immunity and inflammation.

scientific article

The role of NF-kappaB in hypoxia-induced gene expression.

scientific article published on October 2009

Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

scientific article

Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity.

scientific article published on 6 August 2013

Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.

scientific article published on 27 April 2016

c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia

scientific article published in December 2004

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