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List of works by Rene E Toes

A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes

article

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis

scientific article

A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis

scientific article

A dual function for CD40 agonists

scientific article published on 01 June 2000

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

scientific article published in March 2013

A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

scientific article published on 21 May 2013

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

scientific article

A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis

scientific article published on 26 October 2007

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

scientific article

A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels.

scientific article published on 17 December 2015

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes

scientific article

A prediction rule for disease outcome in patients with Recent-onset undifferentiated arthritis: How to guide individual treatment decisions

scientific article published on 01 February 2007

A rapid isolation procedure for dendritic cells from mouse spleen by centrifugal elutriation

scientific article published on 01 October 1992

ACPA (anti-citrullinated protein antibodies) and rheumatoid arthritis.

scientific article published in July 2011

Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.

scientific article

Ability of Interleukin-33- and Immune Complex-Triggered Activation of Human Mast Cells to Down-Regulate Monocyte-Mediated Immune Responses

article

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response

Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells

scientific article published on 13 November 2013

Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes

scientific article published in January 2006

Activation or frustration of anti-tumor responses by T-cell-based immune modulation ⬇️

scientific article published on October 1, 1997

Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region

scientific article published on 5 February 2018

Adipocyte-derived lipids modulate CD4+ T-cell function

scientific article published on 24 April 2013

Adipocytes from the infrapatellar fat pad of OA patients modulate CD4+ T cell cytokine production

scientific article published on 23 November 2011

Adipocytes modulate the phenotype of human macrophages through secreted lipids

scientific article published in July 2013

Adoptive T Cell Immunotherapy of Human Uveal Melanoma Targeting gp100

scientific article published on 01 December 2000

Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritis

scientific article published on 31 October 2009

An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility

scientific article published on 01 September 2005

An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting.

scientific article

Animal models for arthritis: innovative tools for prevention and treatment

scientific article published on 30 May 2011

Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies.

scientific article published on 8 May 2014

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid

scientific article published on 02 October 2020

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

scientific article published on 13 December 2013

Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis

scientific article published in April 2013

Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis.

scientific article

Anti-carbamylated protein antibodies in rheumatoid arthritis patients of Asian descent: Fig. 1

article

Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage

scientific article

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

scientific article published on 2 November 2017

Anti-carbamylated protein antibodies: a specific hallmark for rheumatoid arthritis. Comparison to conditions known for enhanced carbamylation; renal failure, smoking and chronic inflammation

scientific article published on 29 April 2016

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles.

scientific article published on 17 February 2012

Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis.

scientific article published on 06 July 2011

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

scientific article published on 08 October 2013

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis.

scientific article

Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens

scientific article

Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities

scientific article published on 24 August 2010

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

scientific article published on 01 July 2009

Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis

scientific article published on 16 January 2018

Antibodies against collagen type II are not a general marker of acute arthritis onset

scientific article published on 24 August 2017

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

scientific article published on 10 February 2020

Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis

scientific article

Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives

scientific article published on 01 May 2010

Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis

scientific article

Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients

scientific article published on 19 July 2013

Anticarbamylated protein antibodies are associated with long-term disability and increased disease activity in patients with early inflammatory arthritis: results from the Norfolk Arthritis Register.

scientific article published on 06 October 2015

Anticarbamylated protein antibodies can be detected in animal models of arthritis that require active involvement of the adaptive immune system

scientific article published on 04 February 2015

Anticytomegalovirus seropositivity in rheumatoid arthritis is not associated with the presence of severe extraarticular complications: comment on the article by Pierer et al.

scientific article published in August 2012

Antigen-specific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells

scientific article published on 01 October 2004

Antisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis

scientific article published on 24 November 2017

Are ACPA-positive and ACPA-negative RA the same disease?

scientific article published on 01 April 2011

Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?

scientific article published in April 2014

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

scientific article

Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis

article

Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population

scientific article published on 01 November 2009

Association of Variants inIL2RAWith Progression of Joint Destruction in Rheumatoid Arthritis

scientific article published on 01 July 2013

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

article

Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis

scientific article

Association of anti-carbamylated protein antibodies with long-term disability and increased disease activity in patients with early inflammatory arthritis: results from the Norfolk Arthritis Register.

scientific article published on February 2015

Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis

scientific article published in February 2004

Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts

scientific article published in December 2013

Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles.

scientific article published on September 2007

Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis

article

Association of the CCR5Δ32 variant with juvenile idiopathic arthritis in a meta-analysis.

scientific article published on 14 September 2011

Association of the CD226 (DNAM-1) Gly307Ser polymorphism with juvenile idiopathic arthritis.

scientific article

Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.

scientific article

Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis.

scientific article published in March 2009

Association of tumor necrosis factor α polymorphism and radiographic progression in rheumatoid arthritis: Comment on the article by Khanna et al

scientific article published on 01 March 2007

Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies.

scientific article published on April 2015

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.

scientific article

Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study

scientific article published in March 2004

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors

scientific article published on 13 November 2018

Autoantibody testing to predict response to therapy in RA

article

Autoimmune responses in the rheumatoid synovium.

scientific article

Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis

scientific article published on 01 May 2012

B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation

scientific article published on 23 August 2017

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

scientific article published on 13 April 2014

Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes.

scientific article published on 26 February 2018

Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis

scientific article published on 01 September 2011

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis.

scientific article published on 9 March 2017

Bioorthogonal Antigens Allow The Study Of Intracellular Processing And Presentation Of Post-Translationally Modified Antigens

C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.

scientific article published on December 2005

C57BL/6 NK cell gene complex is crucially involved in vascular remodeling

scientific article published on 5 September 2013

CD226(DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis

scientific article published on 23 July 2014

CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.

scientific article

CD25+ regulatory cells from HLA-DQ8 transgenic mice are capable of modulating collagen-induced arthritis

scientific article published on 01 November 2004

CD4+T Cells Are Able to Promote Tumor Growth through Inhibition of Tumor-Specific CD8+T-Cell Responses in Tumor-Bearing Hosts

article

CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

article

Cellular immunity against DNA tumour viruses: possibilities for peptide-based vaccines and immune escape.

scientific article published on August 1995

Cellular-based immune modulation in arthritis

scientific article

Characterization of an immuno 'stealth' derivative of the herpes simplex virus thymidine-kinase gene.

scientific article

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

scientific article published on 05 November 2020

Chimerism levels after stem cell transplantation are primarily determined by the ratio of donor to host stem cells

scientific article published on 01 April 2011

Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis

scientific article published on 26 April 2013

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

scientific article published on 01 December 1997

Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.

scientific article published on April 2005

Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens

scientific article published on 19 May 2015

Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis".

scientific article

Comment on “Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis”

scientific article published on 01 July 2015

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

scientific article published on 14 September 2008

Communication between human mast cells and CD4(+) T cells through antigen-dependent interactions

scientific article published on 13 May 2013

Competition inhibition of cytotoxic T-lymphocyte (CTL) lysis, a more sensitive method to identify candidate CTL epitopes than induction of antibody-detected MHC class I stabilization.

scientific article

Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis

scientific article published in May 2009

Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis.

scientific article

Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation

scientific article published on 16 December 2004

Correction: A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis

scientific article

Correlation between expression of CD44 splice variant v8-v9 and invasiveness of fibroblast-like synoviocytes in an in vitro system.

scientific article

Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1.

scientific article published on November 2003

Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells

article

Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis

scientific article published on 5 May 2015

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

scientific article published on 01 March 2008

DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg

scientific article published in July 2009

DX5(+)CD4(+) T cells modulate cytokine production by CD4(+) T cells towards IL-10 via the production of IL-4.

scientific article published on October 2010

DX5+ CD4+ T cells modulate CD4+ T-cell response via inhibition of IL-12 production by DCs.

scientific article published in February 2013

Decreased serum cell-free DNA levels in rheumatoid arthritis.

scientific article

Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo

scientific article published on 21 September 2006

Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases.

scientific article published on 5 July 2006

Design and evaluation of antigen-specific vaccination strategies against cancer.

scientific article

Detection and Structural Elucidation of Esterified Oxylipids in Human Synovial Fluid by Electrospray Ionization-Fourier Transform Ion-Cyclotron Mass Spectrometry and Liquid Chromatography-Ion Trap-MS3: Detection of Esterified Hydroxylated Docosapenta

scientific article published on 30 May 2013

Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis.

scientific article published on 17 May 2009

Differences in synovial tissue infiltrates between anti–cyclic citrullinated peptide–positive rheumatoid arthritis and anti–cyclic citrullinated peptide–negative rheumatoid arthritis

scientific article published on 01 January 2008

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

scientific article published on 31 May 2019

Differential TLR-induced cytokine production by human mast cells is amplified by FcɛRI triggering.

scientific article published on April 2015

Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study

scientific article

Do autoantibody-responses mature between presentation with arthralgia suspicious for progression to rheumatoid arthritis and development of clinically apparent inflammatory arthritis? A longitudinal serological study

scientific article published on 03 November 2020

Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status

scientific article published on 14 August 2019

Dysferlin regulates cell adhesion in human monocytes.

scientific article

Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes

scientific article published in October 2002

Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.

scientific article

Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double-blind, randomized, placebo-controlled trial

scientific article published on 01 May 2007

Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC.

scientific article published in July 1998

Efficient tumor eradication by adoptively transferred cytotoxic T-cell clones in allogeneic hosts

scientific article published on 01 May 1996

Enhanced concentrations of interleukin 16 are associated with joint destruction in patients with rheumatoid arthritis.

scientific article

Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors

scientific article published on 01 May 1996

Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells

scientific article published on 01 May 1998

Epistasis between two HLA antigens defines a subset of individuals at a very high risk for ankylosing spondylitis

scientific article

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

scientific article

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

scientific article published on 30 March 2018

Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.

scientific article

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.

scientific article

Extensive cross-reactivity of CD4+ adenovirus-specific T cells: implications for immunotherapy and gene therapy.

scientific article

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.

scientific article published on 13 January 2015

FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians

scientific article

Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation

scientific article published on 15 January 2018

Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation

scientific article published on 01 March 2007

Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients

scientific article published on 01 March 2006

Fibroblast-like synoviocytes from rheumatoid arthritis patients express less FLICE-inhibitory protein than fibroblast-like synoviocytes from trauma patients: Comment on the article by Schedel et al

scientific article published on 01 March 2003

Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.

scientific article published on December 2007

Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?

scientific article

Functional and phenotypical analysis of IL-6-secreting CD4+ T cells in human adipose tissue

scientific article published on 28 December 2017

Functional killer Ig-like receptors on human memory CD4+ T cells specific for cytomegalovirus.

scientific article published on April 2009

Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis.

scholarly article

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis

scientific article published on 2 April 2007

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

scientific article

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis

scientific article published on 13 December 2013

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis

scientific article published on 5 October 2012

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

scientific article

Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study

scientific article published on 22 March 2012

Genetic variants in the prediction of rheumatoid arthritis

scientific article published on 03 May 2010

Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.

scientific article published in July 2013

Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis.

scientific article

Genetic variation of the Fc gamma receptor 3B gene and association with rheumatoid arthritis.

scientific article

Genetics of rheumatoid arthritis contributes to biology and drug discovery

scientific article

Genetics of rheumatoid arthritis: what have we learned?

scientific article published on 10 May 2011

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis

scientific article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

scientific article

Genome-wide single-nucleotide polymorphism studies in rheumatology: hype or hope?

scientific article published on September 2008

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

scientific article published in June 2010

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

scientific article

Guiding the action of the immune system: Interactions between the immune system and non-immune tissues

scientific article published on 17 February 2011

HLA and rheumatoid arthritis: how do they connect?

scientific article published on 09 May 2014

HLA class II and rheumatoid arthritis: the bumpy road of revelation

scientific article

HLA-B60 and the HLA-B27/HLA-B60 genotype are not risk factors for acute anterior uveitis.

scientific article

High Levels of Adenovirus DNA in Serum Correlate with Fatal Outcome of Adenovirus Infection in Children after Allogeneic Stem‐Cell Transplantation

scientific article published on 31 July 2002

High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review.

scientific article

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

scientific article

How undifferentiated arthritis evolves into chronic arthritis.

scientific article

Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus

scientific article published in September 2006

Human mast cells costimulate T cells through a CD28-independent interaction

scientific article published on 10 February 2016

IL-17-producing CD4+ T cells are increased in early, active axial spondyloarthritis including patients without imaging abnormalities

scientific article published on 6 October 2014

IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-κB pathway in human B cells to boost antibody production

scientific article published on 16 September 2013

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.

scientific article

Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint

article

Identification of Lifelines participants at high risk for development of rheumatoid arthritis

article

Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis.

scientific article published on 16 August 2013

Identification of a novel non-coding mutation in C1qB in a Dutch child with C1q deficiency associated with recurrent infections.

scientific article published on 18 October 2014

Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis

scientific article published on 10 March 2017

Identification of citrullinated vimentin peptides as T cell epitopes in HLAâ DR4â positive patients with rheumatoid arthritis

scientific article published on 01 January 2010

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

scientific article published on 8 January 2013

IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation.

scientific article

IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis

Immature Dendritic Cells Suppress Collagen-Induced Arthritis by In Vivo Expansion of CD49b+ Regulatory T Cells

scientific article published on 01 September 2006

Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli.

scientific article published in July 2000

Immune response to post-translationally modified proteins in rheumatoid arthritis: what makes it special?

Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion.

scientific article published on April 2004

Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum.

scientific article published on 20 November 2008

Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment

article

Immunomodulatory Dendritic Cells Inhibit Th1 Responses and Arthritis via Different Mechanisms

article

Immunotherapy of cancer by peptide-based vaccines for the induction of tumor-specific T cell immunity ⬇️

scientific article published on November 1, 1996

Importance of CD4(+) T helper cell responses in tumor immunity.

scientific article

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

scientific article published on 01 April 2002

In vivo detection of fluorescent tumor-specific cytotoxic T cell clones

scientific article published on 01 July 1993

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance.

scientific article published on 10 December 2013

Inducing tissue specific tolerance in autoimmune disease with tolerogenic dendritic cells

scientific article published on 12 October 2015

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

scientific article

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

scientific article published on 16 April 2012

Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia.

scientific article published on 3 May 2018

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients.

scientific article published on 10 August 2017

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis

scientific article

Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

scientific article published on February 2004

Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10.

scientific article published on November 2002

Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis

scientific article published on 01 July 2005

Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells

scientific article

Isotype distribution of ANTI–CYCLIC citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response

article

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS

scientific article

Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance

scientific article published on 31 May 2005

Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti-citrullinated protein antibodies

scientific article published on 25 April 2017

Longevity of Antigen Presentation and Activation Status of APC Are Decisive Factors in the Balance Between CTL Immunity Versus Tolerance

scientific article published on 01 September 2001

Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG

scholarly article by Jasmin Knopf et al published July 2018 in Journal of Neuroimmunology

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis.

scientific article published on 5 March 2013

Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease

article

Mast cells in rheumatic disease.

scientific article published on 02 May 2015

Mechanisms of oral tolerance revisited.

scientific article published on 25 April 2008

Mesenchymal stem cells in autoimmune diseases: hype or hope?

scientific article published on 18 June 2010

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

scientific journal article

Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells

scientific article published on 04 December 2007

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.

scientific article published on 11 August 2017

Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8+ T cells in vivo

scientific article published on 28 February 2006

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

scientific article published in 2024

Natural Killer Cells and CD4 + T-Cells Modulate Collateral Artery Development

article

Neutralization of IL-4 reverses the nonresponsiveness of CD4+ T cells to regulatory T-cell induction in non-responder mouse strains.

scientific article published on 25 September 2010

New biomarkers in rheumatoid arthritis

scientific article published on November 1, 2012

Novel genetic association of theVTCN1region with rheumatoid arthritis

scientific article published on 09 February 2012

On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis

scientific article published on 30 August 2019

PADI4 polymorphism predisposes male smokers to rheumatoid arthritis

scientific article published on 09 November 2010

Pathogenic effector functions of ACPA: Where do we stand?

scientific article published on 20 April 2019

Pathogenic relevance of anti–citrullinated vimentin antibodies: Comment on the article by Montes et al ⬇️

scientific article published on February 1, 2013

Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

scientific article published on July 1996

Peptide-based cancer vaccines

scientific article published on 01 October 1996

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

scientific article published on 01 November 2020

Persisting NK cell alloreactivity in the presence of long-term stable hematopoietic chimerism

scientific article published on 25 April 2009

Pitfalls in the detection of citrullination and carbamylation

scientific article published in December 2017

Platelets and autoimmunity.

scientific article published on 26 April 2013

Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis.

scientific article

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands.

scientific article published on 2 January 2017

Pretreatment serum levels of anti-cyclic citrullinated peptide antibodies are associated with the response to methotrexate in recent-onset arthritis

article

Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts

scientific article published on 01 August 2009

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated pr

scientific article

Protection against rheumatoid arthritis by HLA: nature and nurture.

scientific article published on December 2008

Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

scientific article published on December 1997

Protective antitumor immunity induced by immunization with completely allogeneic tumor cells

scientific article published on 01 August 1996

Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA.

scientific article published on 29 December 2015

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

scientific article published on April 2009

RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro

scientific article published on 01 September 2007

RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians

scientific article published on 19 July 2005

Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells

scientific article published on 01 March 2001

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

scientific article

Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method

scientific article

Redefining the HLA and RA association: to be or not to be anti-CCP positive.

scientific article

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins

scientific article

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

scientific article

Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis.

scientific article

Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue

article

Reply

scientific article published on 09 October 2016

Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation

scientific article published on 22 July 2008

Response to: "How to communicate in science" by Klareskog et al

scientific article published on 13 August 2019

Response to: 'Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases' by Visser et al.

scientific article published on 23 November 2017

Response to: 'Comment on editorial 'Pathogenic effector functions of ACPA: where do we stand'' by Holmdahl

scientific article published on 03 July 2019

Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present.

scientific article published in April 2016

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy

scientific article published on July 2010

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation

scientific article published on 01 April 2018

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

scientific article published on 4 August 2017

Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients

scientific article published on 06 March 2007

Rituximab in relapsing Graves' disease, a phase II study.

scientific article published on 15 July 2008

Role of Anti-Carbamylated Protein Antibodies Compared to Anti-Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First-Degree Relatives, and Healthy Controls.

scientific article published on 4 March 2016

Role of TRAIL and IFN-gamma in CD4+ T cell-dependent tumor rejection in the anterior chamber of the eye.

scientific article published on September 2003

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study.

scientific article published on December 2016

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans

scientific article

Studying associations between variants inTRAF1-C5andTNFAIP3-OLIG3and the progression of joint destruction in rheumatoid arthritis in multiple cohorts

scientific article published on 14 May 2012

Successful immunotherapy of an intraocular tumor in mice.

scientific article published in October 1999

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

scientific article published on 09 February 2022

Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies

scientific article published on 11 April 2016

T cell avidity determines the level of CTL activation

scientific article published in July 2004

T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development

article

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

scientific article published in June 1998

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells

scientific article published on 16 April 2014

TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey

scientific article

Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans.

scientific article published on 8 February 2017

Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation

article

The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population

scientific article published on 29 November 2006

The ACPA recognition profile and subgrouping of ACPA-positive RA patients

scientific article published on 13 October 2011

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

scientific article published on 8 February 2018

The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

article

The HLA–DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide

scientific article published on 01 February 2007

The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus

scientific article published on 7 April 2018

The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of HLA-DRB1*0401

scientific article published on 17 January 2006

The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases.

scientific article published on 10 May 2009

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis

scientific article published on 01 July 2008

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis.

scientific article published on 15 September 2008

The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor

scientific article published on 26 April 2016

The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations

scientific article published on 13 March 2013

The contribution of autoantibodies to post-translationally modified proteins to inflammatory arthritis.

scientific article published on 12 December 2016

The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM

scientific article published on 26 July 2017

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

scientific article published on 01 August 2000

The human 26 S and 20 S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate

scientific article published in July 2000

The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules

scientific article published on 3 November 2016

The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis

scientific article

The influence of ACPA status and characteristics on the course of RA.

scientific article published on 31 January 2012

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype.

scientific article

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

scientific article published on 15 August 2017

The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA)

scientific article published on 01 December 2011

The pathogenic potential of autoreactive antibodies in rheumatoid arthritis.

scientific article published on 25 April 2014

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical.

scientific article

The problems and promises of research into human immunology and autoimmune disease

scientific article published on 06 January 2012

The production and secretion of complement component C1q by human mast cells

scientific article

The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia.

scientific article

The role of anticitrullinated protein antibodies in the early stages of rheumatoid arthritis

scientific article published on 4 March 2016

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis.

scientific article published on 24 November 2015

The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment

scientific article published in May 2004

The window of opportunity in ACPA-positive rheumatoid arthritis is not explained by ACPA characteristics

scientific article published on 10 April 2011

Tic-tac-toe does not provide lessons for appreciating the HLA-rheumatoid arthritis relationship: Comment on the editorial by Bridges et al

scientific article published on 01 November 2008

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

scientific article published on 12 May 2014

Toward a data-driven evaluation of the 2010 American College of Rheumatology/European League Against Rheumatism criteria for rheumatoid arthritis: is it sensible to look at levels of rheumatoid factor?

scientific article

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level

scientific article published on 15 June 2004

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

scientific article published on 01 January 2007

Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis

scientific article published on 16 September 2018

Update on autoantibodies to modified proteins.

scientific article

Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice.

scientific article published on 9 October 2009

Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis a

scientific article published on 01 August 2009

Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?

scientific article

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis

scientific article

Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity

scientific article published on 17 February 2016

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