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List of works by Manuel Serrano

"Super p53" mice display retinal astroglial changes.

scientific article

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

scientific article

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

scientific article published in September 2017

A functional link between the tumour suppressors ARF and p33ING1.

scientific article published on 10 April 2006

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

scientific article

A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity ⬇️

scientific article published on April 1, 2011

A new mechanism of inactivation of the INK4/ARF locus

scientific article

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

scientific article

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

scientific article

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

scientific article (publication date: 27 August 2009)

A strategy to study tyrosinase transgenes in mouse melanocytes.

scientific article

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

A versatile drug delivery system targeting senescent cells

scientific article published on 01 September 2018

AAVvector-mediated in vivo reprogramming into pluripotency

scientific article published in Nature Communications

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2

Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1).

scientific article published in November 2002

Activation of replication origins in phi29-related phages requires the recognition of initiation proteins to specific nucleoprotein complexes

scientific article

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

scientific article

Ageing: Tools to eliminate senescent cells

scientific article published on 10 May 2017

An OFF-ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

scientific article published on 18 June 2017

Analysis of p16INK4aand Its Interaction with CDK4

article

Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.

scientific article

Anti-aging activity of the Ink4/Arf locus.

scientific article

Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds

scientific article published on 16 September 2020

Bladder cancer and the Notch pathway

scientific article published in January 2015

Bmi1 puSHHes reprogramming.

scientific article published on 9 August 2011

Cancer Regression by Senescence

scientific article published on 01 May 2007

Cancer and ageing: convergent and divergent mechanisms

scientific article published on September 2007

Cancer: a lower bar for senescence.

scientific article published in March 2010

Cellular senescence in cancer and aging

scientific article

Cellular senescence limits regenerative capacity and allograft survival.

scientific article

Cellular senescence: from physiology to pathology

scientific article

Characterization of a DNA binding protein of bacteriophage PRD1 involved in DNA replication

scientific article published in November 1990

Cloning and characterization of murine p16INK4a and p15INK4b genes

scientific article published on August 17, 1995

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation

scientific article

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

scientific article published on 8 February 2016

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

scientific article published on 02 February 2017

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

scientific article

DNA structure in the nucleoprotein complex that activates replication of phage phi 29.

scientific article published on May 1994

Delayed ageing through damage protection by the Arf/p53 pathway

scientific article published in Nature

Deletion of the p16 and p15 Genes in Human Bladder Tumors

article

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway.

scientific article published on 9 October 2010

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

scientific article published on 03 July 2020

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice

scientific article published on 01 October 2004

Dissecting the role of mTOR complexes in cellular senescence

scientific article published on 15 June 2012

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

scientific article published in 2021

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours

scientific article

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells

scientific article

El ciclo celular y el gen p53. Aproximación a la oftalmología molecular

scientific article published on 01 July 2010

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

scientific article published on 6 June 2013

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

scientific article published on May 2011

Erratum: A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

scholarly article published in Nature Structural & Molecular Biology

Exome sequencing of three cases of familial exceptional longevity.

scientific article

Final act of senescence

scientific article published in Nature

Free [NADH]/[NAD(+)] regulates sirtuin expression.

scientific article

G6PD overexpression protects from oxidative stress and age-related hearing loss

scientific article published on 22 November 2020

G6PD protects from oxidative damage and improves healthspan in mice.

scientific article published on 15 March 2016

GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.

scientific article published on 10 June 2014

Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression

scientific article

Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.

scientific article published on March 2003

Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.

scientific article

Genomic Profiling of Circulating Plasma RNA for the Analysis of Cancer

article

Genomic instability in iPS: time for a break ⬇️

scientific article published on March 16, 2011

Ghrelin requires p53 to stimulate lipid storage in fat and liver

scientific article published on 5 July 2013

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

scientific article published on 28 September 2020

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

scientific article

Histone macroH2A isoforms predict the risk of lung cancer recurrence

scientific article published on 03 August 2009

IFNalpha 2b induces apoptosis and proteasome-mediated degradation of p27Kip1 in a human lung cancer cell line.

scientific article

Identification and characterization of Cardiac Glycosides as senolytic compounds

scientific article published on 21 October 2019

Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.

scientific article

Identification of the gene immediately downstream of the murine INK4a/ARF locus

article

Imaging Cancer in Mice by PET, CT, and Combined PET-CT

scientific article published on 01 March 2011

Impact of Sirt1 on mammalian aging.

scientific article

In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.

scientific article

Inactivation of imprinted genes induced by cellular stress and tumorigenesis

scientific article published in January 2005

Inactivation of the Candidate Tumor Suppressor Par-4 in Endometrial Cancer

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

scientific article published in March 1997

Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging.

scientific article published on 5 December 2012

Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency

scientific article published on 10 November 2011

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline.

scientific article

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

scientific article

Increased gene dosage of the Ink4/Arf locus does not attenuate atherosclerosis development in hypercholesterolaemic mice.

scientific article published on 17 December 2011

Increased p53 activity does not accelerate telomere-driven ageing

scientific article

Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis

article

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

scientific article published on 04 July 2020

Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin

scientific article published in August 2007

Induction of senescence by oncogenic Ras.

scientific article published in January 2001

Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress

scientific article

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

scientific article published in January 1995

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

scientific article published in Journal of Biological Chemistry

Limited role of Sirt1 in cancer protection by dietary restriction

scientific article published on July 2011

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

scientific article

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

scientific article

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

scientific article

Lysosomal trapping of palbociclib and its functional implications

scientific article published on 28 January 2019

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

scientific article

Metformin and reprogramming into iPSCs

scientific article published on 15 March 2012

Mitochondrial Damage Induces Senescence with a Twisted Arm

scientific article published on 01 February 2016

Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas

scientific article published in May 1999

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

scientific article published on 02 March 2022

Multimeric complexes formed by DNA-binding proteins of low sequence specificity.

scientific article

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

scientific article published on September 1999

Mutational effects on the p16INK4a tumor suppressor protein.

scientific article published in June 1995

Mutations and altered expression of p16INK4 in human cancer.

scientific article published in November 1994

Mutations associated with familial melanoma impair p16INK4 function

scientific article published in May 1995

Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer

scientific article (publication date: April 1995)

NOTCH pathway inactivation promotes bladder cancer progression

scientific article

NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.

scientific article published on 08 September 2016

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

scientific article published on 5 February 2018

Nephrin deficiency activates NF-kappaB and promotes glomerular injury

scientific article published on 04 June 2009

Networks of tumor suppressors. Workshop: tumor suppressor networks

scientific article

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

scientific article published on 24 October 2014

Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1).

scientific article published on 11 September 2006

Notching up a new therapeutic strategy for non-small cell lung carcinoma (NSCLC).

scientific article published in September 2012

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

scientific article

Oncogenicity of the developmental transcription factor Sox9.

scientific article

PI3Kα inhibition reduces obesity in mice

scientific article (publication date: 4 November 2016)

PTEN in cancer, metabolism, and aging.

scientific article published on 12 December 2012

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

scientific article published on 18 January 2016

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

scientific article published on June 2011

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis

scientific article

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

scientific article published on 14 October 2015

Phage Ø29 protein p6: A viral histone-like protein

scientific article published on 01 January 1994

Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.

scientific article

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

scientific article

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling ⬇️

scientific article published on October 1, 1998

Programmed cell senescence during mammalian embryonic development

scientific article published on 14 November 2013

Protein-nucleic acid interactions in bacteriophage phi 29 DNA replication.

scientific article

Protein-primed replication of bacteriophage Φ29 DNA

scientific article published on 01 December 1988

Pten positively regulates brown adipose function, energy expenditure, and longevity

scientific article

Putting the stress on senescence

scientific article

Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1).

scientific article published in March 2009

Regulation of mature T lymphocyte proliferation and differentiation by Par-4

scientific journal article

Regulation of the INK4a/ARF locus by histone deacetylase inhibitors

scientific article

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer

scientific article published on 10 June 2013

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

scientific article

Resistance to viral infection of super p53 mice.

scientific article published in April 2005

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

scientific article published on 28 May 2021

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.

scientific article published on 28 April 2015

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

scientific journal article

Role of the INK4a locus in tumor suppression and cell mortality

scientific article

SHP2: a new target for pro-senescence cancer therapies.

scientific article published on 27 April 2015

SIRT1 contributes to telomere maintenance and augments global homologous recombination

scientific article

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.

scientific article published on 31 March 2014

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

scientific article

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.

scientific article

SIRT1 stabilizes PML promoting its sumoylation

scientific article

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.

scientific article

SIRT1: recent lessons from mouse models.

scientific article published on 24 November 2010

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

scientific article

Senescence and Cancer: In the Name of Immunosuppression

scientific article published in October 2016

Senescence helps regeneration

scientific article published in December 2014

Senescence promotes in vivo reprogramming through p16INK4a and IL-6.

scientific article published on 27 December 2017

Shifting senescence into quiescence by turning up p53 ⬇️

scientific article published on November 28, 2010

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.

scholarly article

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

scientific article published on 12 April 2010

Sirt1 protects against high-fat diet-induced metabolic damage

scholarly article

Sirt1 protects from K-Ras-driven lung carcinogenesis

scientific article published on 18 July 2018

Sirtuin 1 regulation of developmental genes during differentiation of stem cells.

scientific article

Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer

scientific article published on 31 January 2013

Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis

scientific article published on 01 September 2006

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.

scientific article published on 2 February 2016

Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4.

scientific article published on May 1996

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

scientific article published on 01 August 2018

Targeting senescence

scientific article published on 01 August 2018

Targeting γ-secretases protect against angiotensin II-induced cardiac hypertrophy

scientific article published on April 2015

Telomerase reverse transcriptase delays aging in cancer-resistant mice

scientific article

Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells

scientific article

The Arf/p53 pathway in cancer and aging

scientific article published on August 2008

The InflammTORy Powers of Senescence.

scientific article

The Ink4/Arf locus is a barrier for iPS cell reprogramming

scientific article (publication date: 27 August 2009)

The PTEN/NRF2 axis promotes human carcinogenesis

scientific article

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

scientific article published in January 2018

The TRIP from ULF to ARF

scientific article published on 01 April 2010

The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine

scientific article

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis

scientific article published in February 2004

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

scientific article published in February 2000

The common biology of cancer and ageing

scientific article published on August 2007

The hallmarks of aging

scientific article

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

scientific journal article

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

scientific journal article

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

scientific article published on 19 May 2015

The power and the promise of oncogene-induced senescence markers

scientific article

The senescent side of tumor suppression

scientific article

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

scientific article published on 13 February 2011

The tumor suppressor protein p16INK4a.

scientific article published on November 1997

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

scientific article published on August 14, 2012

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

scientific article

Transcription activation at a distance by phage phi 29 protein p4. Effect of bent and non-bent intervening DNA sequences

scientific article

Transcription regulation in Bacillus subtilis phage phi 29.

scientific article published on September 1991

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins.

scientific article published on February 2015

Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells

scientific article published on 02 July 2020

Troponin-I enhances and is required for oncogenic overgrowth

scientific article published on 15 July 2016

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

scientific article published on August 2003

Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.

scientific article published on 4 February 2002

Tumor suppressors and oncogenes in cellular senescence.

scientific article

Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma

scientific article

Tumour biology: Policing of oncogene activity by p53

scientific article published in Nature

Tumour biology: senescence in premalignant tumours

scientific article published on August 2005

Understanding Aging

scientific article published in March 2017

Unraveling the links between cancer and aging.

scientific article published on 30 December 2015

WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway

scientific article

Young and Lean: Elimination of Senescent Cells Boosts Adaptive Thermogenesis.

scientific article published in February 2017

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

scientific article

p16 INK4 Mutations and Altered Expression in Human Tumors and Cell Lines ⬇️

scientific article published on January 1, 1994

p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis

scientific article

p19ARF links the tumour suppressor p53 to Ras

scientific article published in Nature

p21(Cip1) plays a critical role in the physiological adaptation to fasting through activation of PPARα.

scientific article published on 10 October 2016

p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.

scientific article published on December 2012

p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo

scientific article

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

scientific article

p53: guardian of the genome and policeman of the oncogenes.

scientific article published on 28 May 2007

p73β-Mediated Apoptosis Requires p57kip2Induction and IEX-1 Inhibition

scientific article published on 01 March 2005

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

scientific article published on 31 March 2017

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