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List of works by David A. Lee

A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation

scientific article published in January 1998

A system for monitoring the response of uniaxial strain on cell seeded collagen gels

scientific article published on 01 June 2000

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles

scientific article published on 25 October 2005

An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.

scientific article

Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.

scientific article published in August 2011

Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes

scientific article

Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture.

scientific article published in January 2005

Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen

scientific article published on 22 January 2016

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

scientific article

Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates.

scientific article

Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.

scientific article published in February 2002

Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.

scientific article published on September 2012

Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs

scientific article published in January 2009

Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs

scientific article published in September 2004

Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion.

scientific article published on 16 December 2015

Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields.

scientific article

Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.

scientific article

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose

scientific article published on 01 May 2001

Compressive Deformation and Damage of Muscle Cell Subpopulations in a Model System

article

Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose

scientific article published on 01 March 1997

Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose

scientific article published on 01 March 2000

Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells

scientific article published on 12 October 2012

Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels

scientific article published in March 2004

Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.

scientific article published on February 2014

Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.

scientific article published in October 2005

Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification

scientific article published on 2 February 2017

Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro

scientific article published on 26 November 2008

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

scientific article

Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs

scientific article published in September 2003

Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

scientific article published on 18 March 2008

Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs

scientific article published in August 2001

Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study

scientific article published on 18 July 2011

Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose

scientific article published on 01 October 1998

Dynamic regulation of nuclear architecture and mechanics-a rheostatic role for the nucleus in tailoring cellular mechanosensitivity.

scientific article published on 2 February 2017

Effects of ascorbate on myogenesis in micromass culture

scientific article published on 01 March 1990

Electrospray deposited fibronectin retains the ability to promote cell adhesion.

scientific article published on January 2011

Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques

scientific article published in February 2003

Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain.

scientific article published on 24 May 2010

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment

scientific article published on 11 December 2018

Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.

scientific article

Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs.

scientific article published in December 2006

Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage

scientific article published on 01 January 2004

Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels

scientific article published in August 2003

Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes

scientific article published on 17 March 2006

Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes

scientific article

Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.

scientific article published in January 2010

Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.

scientific article

Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose

scientific article published on 27 June 2005

Mechanical conditioning influences the metabolic response of cell-seeded constructs.

scientific article published on January 2003

Mechanical regulation of nuclear structure and function.

scientific article published on 22 May 2012

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells.

scientific article

Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.

scientific article published on 12 June 2008

Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach.

scientific article

Oxygen tension modulates the effects of TNFα in compressed chondrocytes

scientific article published on 22 September 2016

Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants

scientific article published on 01 September 1994

Quantification of chromatin condensation level by image processing

scientific article published on 5 October 2013

Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue

scientific article published in December 1996

Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration

scientific article published on February 2006

Response of chondrocyte subpopulations cultured within unloaded and loaded agarose

scientific article published on 01 November 1998

Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells

scientific article published on 17 December 2018

Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression

scientific article published in July 2008

Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.

scientific article

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.

scientific article

Stem cell mechanobiology.

scientific article published on January 2011

Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor

scientific article published on 21 December 2018

Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival

scientific article published on 11 December 2018

Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression

scientific article published in September 2003

The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin

scientific article published on 17 November 2011

The control of cell division in articular chondrocytes

scientific article published on 01 April 1993

The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes

scientific article published on 01 December 1995

The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties.

scientific article published in January 2009

The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose

scientific article published on 01 October 1998

The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.

scientific article published in August 2005

The influence of swelling and matrix degradation on the microstructural integrity of tendon.

scientific article published on 12 July 2006

The mechanics of flexor tendon adhesions

scientific article published on 14 December 2011

The metabolism of human mesenchymal stem cells during proliferation and differentiation.

scientific article

Time dependence of cyclic tensile strain on collagen production in tendon fascicles

scientific article published on 13 August 2007

Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility.

scientific article published in January 2016

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