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List of works by David Meyerholz

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

scientific article published on 03 August 2020

A Novel Model of Severe Gallstone Pancreatitis: Murine Pancreatic Duct Ligation Results in Systemic Inflammation and Substantial Mortality ⬇️

scientific article published on October 26, 2010

A forensic investigation into the etiology of bat mortality at a wind farm: barotrauma or traumatic injury?

scientific article published on 30 January 2012

A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

scientific article

A porcine model of neurofibromatosis type 1 that mimics the human disease

scientific article published on 21 June 2018

Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension.

scientific article published on 13 January 2017

Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice

scientific article

Actinobacillus capsulatus septicemia in a domestic rabbit (Oryctolagus cuniculus).

scientific article published in January 2005

Adaptive Immunity Does Not Strongly Suppress Spontaneous Tumors in a Sleeping Beauty Model of Cancer ⬇️

scientific article published on March 8, 2013

Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs.

scientific article published on October 2004

Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

scientific article published in 2024

Advancing translational research

scientific article published on 01 March 2011

Air trapping and airflow obstruction in newborn cystic fibrosis piglets

scientific article published on December 2013

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

scientific article published on January 2016

Alcian Blue and Pyronine Y histochemical stains permit assessment of multiple parameters in pulmonary disease models.

scientific article

Allograft Inflammatory Factor 1 as an Immunohistochemical Marker for Macrophages in Multiple Tissues and Laboratory Animal Species

scientific article published on 18 September 2018

An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis

scientific article published on November 2011

An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate.

scientific article

An investigation of p53 in skeletal muscle aging

scientific article published on 29 August 2019

Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways

scientific article published on 22 February 2019

Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology.

scientific article

Animal models: Software for study design falls short

scientific article published on 01 April 2016

Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease

scientific article

Approaches to Evaluate Lung Inflammation in Translational Research.

scientific article

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

scientific article published on 01 November 2019

Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae

scientific article

CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjögren syndrome

scientific article published on 3 May 2017

CF airway smooth muscle transcriptome reveals a role for PYK2.

scientific article published on 7 September 2017

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

scientific article published on 09 November 2020

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

scientific article published on 9 August 2011

Challenges and Opportunities for the Veterinary Pathologist in Biomedical Research

scientific article published on 17 December 2020

Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation

scientific article

Citation Index Is Not Critically Important to Veterinary Pathology, Medicine, and Research

scientific article published on 01 July 2018

Collectins and cationic antimicrobial peptides of the respiratory epithelia.

scientific article published on September 2006

Common Pitfalls in Analysis of Tissue Scores

scientific article published on 21 August 2018

Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model.

scientific article published on 29 January 2009

Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model

scientific article

Congenital fetal rhabdomyoma in a foal

scientific article published on 01 September 2004

Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.

scientific article

Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence

scientific article published on 2 August 2010

Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility

scientific article published on 21 October 2015

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

scientific article

Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice.

scientific article

Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis

scientific article published on 27 April 2007

Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis

scientific article published on 01 April 2018

Derivation of adult canine intestinal organoids for translational research in gastroenterology

scientific article published on 11 April 2019

Development and translational imaging of a TP53 porcine tumorigenesis model

scientific article

Development of a porcine model of cystic fibrosis.

scientific article published on January 2009

Developmental expression and distribution of sheep beta-defensin-2.

scientific article published in February 2004

Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus.

scientific article published in January 2006

Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia.

scientific article

Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus

scientific article

Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome

scientific article

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

scientific article

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

scientific article published on September 2008

Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression.

scientific article

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice.

scientific article published on February 2016

Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileum.

scientific article published in November 2002

Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model

scientific article published on 27 July 2020

Ecology: Bat deaths from wind turbine blades.

scientific article published in August 2012

Ectopic Expression of Zmiz1 Induces Cutaneous Squamous Cell Malignancies in a Mouse Model of Cancer ⬇️

scientific article published on February 20, 2013

Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia

scientific article

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense

scientific article published on 22 January 2016

Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

scientific article published on 28 October 2019

Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs

scientific article

Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.

scientific article published on 27 October 2017

Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations

scientific article published in 2024

Evolving challenges to model human diseases for translational research

scientific article published on 04 March 2020

Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of the fetal lung ⬇️

scientific article published on December 15, 2010

Ferret lung transplant: an orthotopic model of obliterative bronchiolitis.

scientific article published on 3 December 2012

Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections

scientific article published on June 2009

Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection

scientific article

Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia

scientific article published on 22 January 2014

Fundamental Concepts for Semiquantitative Tissue Scoring in Translational Research

scientific article published on 01 December 2018

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.

scientific article published on 15 March 2014

Gel-forming mucins form distinct morphologic structures in airways

scientific article

Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response.

scientific article published on 02 February 2009

Genetic Ataxia Telangiectasia porcine model phenocopies the multisystemic features of the human disease.

scientific article

Genetically modified species in research: opportunities and challenges for the histology core laboratory ⬇️

scientific article published on July 1, 2012

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

scientific article

Glycogen depletion can increase the specificity of mucin detection in airway tissues

scientific article published on 25 October 2018

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

scientific article published on 24 April 2020

Histopathologic Evaluation and Scoring of Viral Lung Infection

scientific article published on 01 January 2020

Hyaluronan Modulation Impacts Staphylococcus aureus Biofilm Infection

scientific article published on 11 April 2016

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

scientific article published on 29 July 2019

IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease.

scientific article published in February 2008

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy.

scientific article

Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans

scientific article published on 27 October 2015

Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.

scientific article published on August 2017

Immunohistochemical detection of arginase-I expression in formalin-fixed lung and other tissues

scientific article

Increased susceptibility to otitis media in a Splunc1-deficient mouse model

scientific article

Insulin-like growth factor-1 levels contribute to the development of bacterial translocation in sepsis.

scientific article

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

scientific article published on 8 May 2013

Keratoacanthoma Pathobiology in Mouse Models

scientific article published on May 2014

Lack of airway submucosal glands impairs respiratory host defenses

scientific article published on 07 October 2020

Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs.

scientific article published on 21 February 2018

Latent Membrane Protein 1, the EBV-Encoded Oncogenic Mimic of CD40, Accelerates Autoimmunity in B6.Sle1 Mice ⬇️

scientific article published on October 1, 2010

Lentiviral-mediated phenotypic correction of cystic fibrosis pigs

scientific article published on September 2016

Lessons learned from the cystic fibrosis pig.

scientific article published on 21 April 2016

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

scientific article published on November 2006

Longitudinal phenotype development in a minipig model of neurofibromatosis type 1

scientific article published on 19 March 2020

Loss of RHBDF2 results in an early-onset spontaneous murine colitis

scientific article published on 29 January 2019

Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children

scientific article

Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation

scientific article published on 02 March 2020

Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

scientific article published in PLoS ONE

Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets.

scientific article

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

scientific article published on 5 March 2018

Maintenance of Distal Intestinal Structure in the Face of Prolonged Fasting: A Comparative Examination of Species From Five Vertebrate Classes

scientific article

Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

scientific article published on 5 December 2012

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.

scientific article published on 2 January 2018

Microglia are required for protection against lethal coronavirus encephalitis in mice

scientific article published on 29 January 2018

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4.

scientific article published on 20 October 2015

Modeling Emergent Diseases: Lessons From Middle East Respiratory Syndrome.

scientific article published on 21 March 2016

Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

scientific article published on 14 August 2009

Monocytic/macrophagic pneumonitis after intrabronchial deposition of vascular endothelial growth factor in neonatal lambs.

scientific article published on September 2006

Morphologic characterization of early ligation-induced acute pancreatitis in rats

scientific article

Morphological parameters for assessment of burn severity in an acute burn injury rat model.

scientific article published in February 2009

Mounier-Kuhn syndrome: a case of tracheal smooth muscle remodeling.

scientific article published on 29 December 2016

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

scientific article published on 27 March 2017

Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection

scientific article published on 15 August 2011

Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus

scientific article

Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury

scientific article published on 11 September 2008

NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas

scientific article

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia

scientific article published on 07 June 2018

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus

scientific article

Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat.

scientific article published on 22 September 2016

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe

scientific article published on 02 February 2014

Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet

scientific article

Observational Study Design in Veterinary Pathology, Part 1: Study Design

scientific article published on 02 August 2018

Observational Study Design in Veterinary Pathology, Part 2: Methodology

scientific article published on 18 September 2018

Origins of cystic fibrosis lung disease

scientific article published on 01 April 2015

Origins of cystic fibrosis lung disease

scientific article

Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice

scientific article

Pancreatic and biliary secretion are both altered in cystic fibrosis pigs.

scientific article

Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways

scientific article

Pancreatic pathophysiology in cystic fibrosis

scientific article

Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection

scientific article published on 18 March 2015

Pathology and Pathogenesis of Immune-Mediated Diseases of Animals.

scientific article published in January 2018

Patterns of host gene expression associated with harboring a foregut microbial community

scientific article published on 6 September 2017

Pharmacologic modification to resuscitation fluid after thermal injury--is drotrecogin alfa the answer to arrest burn depth progression?

scientific article

Porcine cancer models for translational oncology

scientific article published on October 2014

Postnatal airway growth in cystic fibrosis piglets

scientific article published on 15 June 2017

Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection

scientific article published on 16 December 2019

Principles and approaches for reproducible scoring of tissue stains in research

scientific article published on 30 May 2018

Principles for valid histopathologic scoring in research.

scientific article published on 04 April 2013

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

scientific article

Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.

scientific article published on July 2009

RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth

scientific article published on 04 March 2019

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

scientific article published on 21 February 2020

RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets

scientific article

Radiomic biomarkers informative of cancerous transformation in neurofibromatosis-1 plexiform tumors

scientific article published on 27 June 2018

Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention

scientific article published on 07 June 2019

Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

scientific article published on 26 August 2009

Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104.

scientific article published in October 2001

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.

scientific article published on 21 May 2008

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection.

scientific article

Simple and reproducible approaches for the collection of select porcine ganglia.

scientific article published on 08 June 2017

Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis

scientific article

Solitary Cholinergic Stimulation Induces Airway Hyperreactivity and Transcription of Distinct Pro-inflammatory Pathways

scientific article published on 29 January 2018

Solitary retinal astrocytoma in a dog.

scientific article published in March 2004

Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis.

scientific article

Successful integration of the histology core laboratory in translational research ⬇️

scientific article (publication date: April 2012)

Surfactant-associated protein A provides critical immunoprotection in neonatal mice.

scientific article

Surveillance of amyloidosis and other diseases at necropsy in captive trumpeter swans (Cygnus buccinator)

scientific article published on 01 May 2005

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

scientific article published on 23 August 2009

Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis

scientific article published on 29 July 2011

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

scientific article

Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen.

scientific article published on 23 June 2014

Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells

scientific article published on 05 March 2019

Teaching medical pathology in the twenty-first century: virtual microscopy applications.

scientific article

The "Naked Truth": Naked Mole-Rats Do Get Cancer

scientific article published on 21 March 2016

The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.

scientific article

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

scientific article published on 13 December 2016

The Evolving Significance and Future Relevance of the Impact Factor.

scientific article published on July 2017

The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation

scientific journal article

The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia

scientific article published on September 2016

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.

scientific article published on 25 October 2012

The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice

scientific article

The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis

scientific article

The porcine lung as a potential model for cystic fibrosis

scientific article published on 16 May 2008

The role of LEF1 in endometrial gland formation and carcinogenesis

scientific article

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity.

scientific article published on 5 April 2018

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs

scientific article

Tim-1 regulates Th2 responses in an airway hypersensitivity model.

scientific article published on March 2012

Transepithelial migration of neutrophils into the lung requires TREM-1

scientific journal article

Unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse

scientific article published on 01 July 2005

Validating indicators of CNS disorders in a swine model of neurological disease

scientific article published on 19 February 2020

Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.

scientific article published on 19 June 2017

Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection

scientific article

Where's the mouse pathology training?

scientific article published on 01 November 2009

Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus

scholarly article by Ashley L Cooney et al published 12 October 2018 in Nucleic Acids Research

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