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List of works by Benoit Viollet

5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

scientific article

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

scientific article published on 01 April 2006

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo

scientific article published on 08 January 2014

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

scientific article published in January 2004

A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3'UTR mechanism

scientific article published on 22 March 2018

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

scientific article published on 2 April 2007

A functional role for AMPK in female fertility and endometrial regeneration

scientific article published on 01 December 2018

A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

scientific article published on 03 October 2006

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

scientific article

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

scientific article

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

scientific article

AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

scientific article published on 27 July 2010

AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice

scientific article

AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice

scientific article published on 06 October 2008

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development

scientific article

AMP-Activated Protein Kinase Signalling ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis.

scientific article published on 27 June 2016

AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?

scientific article published on 16 April 2015

AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea.

scientific article published on 15 December 2015

AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.

scientific article published on 13 July 2016

AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass

scientific article published on 24 April 2010

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

scientific article

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

scientific article published on 14 October 2009

AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function.

scientific article

AMP-activated protein kinase and metabolic control

scientific article published on January 2011

AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.

scientific article

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

scientific article published on 19 February 2009

AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

scientific article

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation

scientific article published on 4 February 2008

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

scientific article published in May 2015

AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5

scientific journal article

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

scientific article published on 27 May 2016

AMP-activated protein kinase pathway and bone metabolism

scientific article published on 08 September 2011

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

scientific article published on 21 April 2008

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

scientific article

AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts

scientific article

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

scientific article published on 31 October 2014

AMP-activated protein kinase α1 but not α2 catalytic subunit potentiates myogenin expression and myogenesis

scientific article published on 16 September 2013

AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity

scientific article

AMP-activated protein kinase α2 and E2F1 transcription factor mediate doxorubicin-induced cytotoxicity by forming a positive signal loop in mouse embryonic fibroblasts and non-carcinoma cells

scientific article published on 07 January 2014

AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. ⬇️

scientific article

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

scientific article

AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

scientific article published on June 2007

AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells

scientific article published on 18 October 2019

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

scholarly article by Marc Foretz published in September 2018

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation in Vivo

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis

scientific article

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

scientific article published on 9 January 2018

AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs

scientific article published on 10 July 2015

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1.

scientific article

AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors

scientific article published on 31 January 2013

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

scientific article

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

scientific article

AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol

scientific article published in November 2011

AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle

scientific article

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After - But Not During - Exercise and Contraction

scientific article published on 22 April 2019

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

scientific journal article

AMPK and the Metabolic Syndrome

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

scientific article

AMPK as a therapeutic target in renal cell carcinoma

scientific article

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated

scientific article published on 31 March 2009

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

scientific article published on 20 March 2014

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

scientific article published on 25 October 2013

AMPK in skeletal muscle function and metabolism.

scientific article published on 14 December 2017

AMPK inhibition in health and disease

scientific article

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

scientific article published on 27 December 2012

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

scientific article

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes.

scientific article published on 4 October 2017

AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis

scientific article published on 21 December 2015

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

scientific article published on 19 August 2019

AMPK regulates circadian rhythms in a tissue- and isoform-specific manner

scientific article

AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability

scientific article published on 17 June 2010

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

scientific article published on 01 July 2006

AMPK-independent induction of autophagy by cytosolic Ca2+ increase.

scientific article

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

scientific article published on 09 September 2016

AMPK: Lessons from transgenic and knockout animals

scientific article published on January 2009

AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress

scientific article

AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol

scientific article published on 21 September 2008

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes

scientific article

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

scientific article published on 21 January 2015

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

scientific article published on 29 September 2015

AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression

scientific article published on 6 September 2013

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

scientific article published on 24 July 2013

AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

scientific article published in August 2013

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.

scientific article published on 17 May 2017

AMPKα1: a glucose sensor that controls CD8 T-cell memory

scientific article published on 13 February 2013

AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells

scientific article published on 6 October 2011

Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo

scientific article published on 03 January 2013

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

scientific article

Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway

scientific article

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

scientific article published on 24 May 2007

Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase

scientific article

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

scientific article

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

scientific article

Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells

scientific article

Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo

scientific article published on June 2012

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol.

scientific article published on 10 May 2018

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.

scientific article

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

scientific article published in May 2017

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

scientific article published in February 2006

Activation of the AMP-activated protein kinase by eicosapentaenoic acid (EPA, 20:5 n-3) improves endothelial function in vivo

scientific article

Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation

scientific article published on 10 October 2013

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

scientific article

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

scientific article

Animal Models to Study AMPK.

scientific article published on January 2016

Antagonistic control of muscle cell size by AMPK and mTORC1.

scientific article published on 15 August 2011

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

scientific article published on 14 July 2016

Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

scientific article

Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A.

scientific article published on 12 December 2014

Autophagy controls p38 activation to promote cell survival under genotoxic stress

scientific article published on 4 December 2012

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

scientific article published on 25 September 2017

Basal autophagy induction without AMP-activated protein kinase under low glucose conditions

scientific article

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

scientific article published on 01 January 1996

Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators

scientific article published on January 2009

Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism

scientific article published on June 2015

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

scientific article

Biotin deprivation impairs mitochondrial structure and function and has implications for inherited metabolic disorders.

scientific article published in September 2015

Bypassing AMPK Phosphorylation

scientific article published on 01 May 2014

CCCP induces autophagy in an AMPK-independent manner.

scientific article

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation

scientific article

Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.

scientific article

Cellular and molecular mechanisms of metformin: an overview

scientific article

Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.

scientific article published on January 2011

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

scientific article published on 14 February 2019

Chronic Intermittent Hypoxia Impairs Insulin Sensitivity but Improves Whole-Body Glucose Tolerance by Activating Skeletal Muscle AMPK.

scientific article

Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway

scientific article

Close encounters of a novel kind: a multi-targeted cancer drug meets a metabolic sensor

scientific article published in July 2010

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

scientific article published on 20 May 2015

Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α₁-AMPK-/- mice

scientific article

Compound C inhibits hypoxic activation of HIF-1 independent of AMPK

scientific article

Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform

scientific article published in December 2013

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase

scientific article published on 11 May 2010

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

scientific article published on 16 August 2017

Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes

scientific article published on 30 December 2008

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

scientific article

Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis

scientific article published on 04 February 2021

Development of hepatic fibrosis occurs normally in AMPK-deficient mice

scientific article published on 14 December 2009

Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. ⬇️

scientific article

Differential effects of AMPK agonists on cell growth and metabolism

scientific article published on 22 September 2014

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart

scientific article published on 4 March 2013

Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors

scientific article

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

scientific article published on 13 January 2014

Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion

scientific article

Editorial (Thematic Issue: AMPK: New Frontiers in Human Diseases)

scientific article published on 01 January 2016

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

scientific article published on 5 May 2005

Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes

scientific article published on June 2001

Endothelial autophagic flux hampers atherosclerotic lesion development

scientific article published on 20 November 2017

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction

scientific article published on 14 January 2019

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

scientific article published on 26 October 2016

Erratum to: AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated

scholarly article published in Pfluegers Archiv

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

scientific article published on 25 July 2018

Expanding roles for AMPK in skeletal muscle plasticity

scientific article published on 26 March 2015

Expression of Uncoupling Protein 3 and GLUT4 Gene in Skeletal Muscle of Preterm Newborns: Possible Control by AMP-Activated Protein Kinase

article

Finely-tuned regulation of AMP-activated protein kinase (AMPK) is crucial for human adult erythropoiesis

scientific article published on 11 October 2018

From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target

scientific article published in April 2006

Functional analysis of the glucose response element of the rat glucagon receptor gene in insulin-producing INS-1 cells

scientific article

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

scientific article published on 22 December 2016

Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice

scientific article published on 13 March 2013

Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.

scientific article published in August 2013

Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents

scientific article published on 17 March 2020

Hepatic peroxisome proliferator-activated receptor γ coactivator 1α and hepcidin are coregulated in fasted/refed states in mice

scientific article published on 14 August 2012

Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes

scientific journal article

Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase

scientific article

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

scientific article published on 03 August 2009

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

scientific article published on 3 March 2009

Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

scientific article published on 26 November 2007

Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms

scientific article

Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits

scientific article

Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy

scientific article published on 23 February 2009

In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I

scientific article published on 15 June 2009

Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology

scientific article

Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients

scientific article

Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit

scientific article

Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo

scientific article published on 7 January 2013

Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.

scientific article

Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells

scientific article published on 26 June 2019

Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice

scientific article

Interleukin-6 deletion in mice driven by aP2-Cre-ERT2 prevents against high-fat diet-induced gain weight and adiposity in female mice

scientific article published in July 2014

Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis

scientific article published on 09 February 2022

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice

scientific article published in September 2008

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

scientific article

Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.

scientific article published on October 2009

Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival

scientific article published on 5 January 2012

Iron overload inHepc1−/−mice is not impairing glucose homeostasis

scientific article published on 12 February 2007

Kidney-specific genetic deletion of both AMPK α-subunits causes salt and water wasting.

scientific article published on 9 November 2016

Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System.

scientific article published in January 2018

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

scientific article published on 21 October 2003

LKB1 and AMPK regulate synaptic remodeling in old age

scientific article published on 03 August 2014

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

scientific article published on 31 January 2015

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration

scientific article published in February 2018

LKB1/AMPK pathway in the control of hepatic energy metabolism

LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication

scientific article

Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exercise

scientific article published on 21 August 2007

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis

scientific article

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

scientific article published on 13 October 2014

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

scientific article

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin

scientific article published on 2 February 2006

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

scientific article

Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle

scientific article published on 6 March 2012

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

scientific article

Loss of Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis

scientific article published on 23 October 2018

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

scientific article

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

scientific journal article

Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit

scientific article published on 27 July 2010

Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells.

scientific article

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

scientific article

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK

scientific article

Mechanism of inhibition of hepatic glucose production by metformin: a new concept for an old remedy

scientific article published on June 2010

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

scientific article published on 25 April 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

scientific article published on 01 June 2019

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

scientific article (publication date: December 2015)

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

scientific article published on 23 September 2011

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

scientific article published on 08 May 2018

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

scientific article

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

scientific article published on 23 January 2020

Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2.

scientific article

Metformin reduces endogenous reactive oxygen species and associated DNA damage

scientific article published on 18 January 2012

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.

scientific article

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

scientific article

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

scientific article

Metformin: from mechanisms of action to therapies

scientific article published on 30 October 2014

Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment.

scientific article

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

scientific article published on 4 January 2016

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α.

scientific article published on 20 December 2014

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice

scientific article published on 26 July 2017

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate

scientific article published on 13 February 2015

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

scientific article published on 25 September 2020

Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.

scientific article published on 20 April 2016

Mécanisme d’action hépatique de la metformine dans le diabète de type 2

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke

scientific article published on 27 September 2007

New promises for metformin: advances in the understanding of its mechanisms of action

scientific article

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

scientific article published on 19 January 2011

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.

scientific article

Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes

scientific article

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

scientific article

PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation

scientific article

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer

scientific article published on 30 June 2020

Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice

scientific article published on 9 October 2012

Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase

scientific article

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

article

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

scientific article published on 8 November 2016

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

scientific article (publication date: 28 January 2011)

Physiological roles of AMP-activated protein kinase (AMPK)

scientific article published in May 2003

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

scientific article published on 22 September 2005

Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation

scientific article

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

scientific article

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

scientific article

Promise and challenges for direct small molecule AMPK activators

scientific article published on 3 February 2018

Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4 ⬇️

scientific article published on August 1, 1997

Protein kinase CK2 acts as a signal molecule switching between the NDPK-A/AMPK alpha1 complex and NDPK-B.

scientific article

Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes

scientific article published on 9 December 2011

Proteome analysis of erythrocytes lacking AMP-activated protein kinase reveals a role of PAK2 kinase in eryptosis

scientific article

Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1.

scientific article

Regulation of Cl(-) secretion by AMPK in vivo

scientific article published on 28 August 2008

Regulation of hepatic metabolism by AMPK ⬇️

scientific article published on October 14, 2010

Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT).

scientific article

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

scientific article published on 18 June 2008

Revisiting the mechanisms of metformin action in the liver ⬇️

scientific article published on April 10, 2013

Role of AMP-activated protein kinase in autophagy and proteasome function

scientific article published on 6 March 2008

Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells

scientific article published on 8 October 2013

Role of AMP-activated protein kinase in the regulation of gene transcription

scientific article

Role of AMPK in UVB-induced DNA damage repair and growth control

scientific article

Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

scientific article

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

scientific article published on 18 October 2021

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle

scientific article published on 25 September 2008

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling

scientific article

Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia

scientific article

Régulation du métabolisme énergétique par l’AMPK

scientific article published on 01 April 2006

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase

scientific article published in June 2007

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

scientific article

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality

scientific article published on 6 January 2016

Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology

scientific article

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver

scientific article

Stimulation of human and mouse erythrocyte Na(+)-K(+)-2Cl(-) cotransport by osmotic shrinkage does not involve AMP-activated protein kinase, but is associated with STE20/SPS1-related proline/alanine-rich kinase activation

scientific article published on 4 May 2010

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.

scientific article published on 4 December 2017

Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK.

scientific article

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

scientific article

TATA binding protein discriminates between different lesions on DNA, resulting in a transcription decrease

scientific article published on July 1998

TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance

scientific article published on 5 December 2013

Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

scientific article published on 7 November 2007

Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators

scientific article

Targeting the AMPK pathway for the treatment of Type 2 diabetes

scientific article published on January 2009

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

scientific article

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

article by Benoit Viollet et al published 1 January 2003 in Journal of Clinical Investigation

The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions.

scientific article published on 13 February 2014

The AMPK-v-ATPase-pH axis: A key regulator of the pro-fibrogenic phenotype of human hepatic stellate cells.

scientific article published on 17 April 2018

The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia.

scientific article published on 29 September 2010

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

scientific article

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

scientific article published on 28 July 2010

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

scientific article

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

scientific article published in December 2004

The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing.

scientific article published on 04 May 2013

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

scientific article published on 18 September 2017

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo

scientific article published on 2 January 2015

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

scientific article

The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia

scientific article

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

scientific article published on 10 February 2020

Therapy: Metformin takes a new route to clinical efficacy

scientific article

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

scientific article published on April 2001

Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin

scientific article

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection

scientific article

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

scientific article published on 22 August 2019

Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1

scientific article published in August 2006

Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes

scientific article

Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet beta-cells.

scientific article

[« Self-eating » to survive - coordinated regulation of autophagy by nutrients].

scientific article

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

scientific article published on 25 July 2016

α1AMP-activated protein kinase mediates vascular protective effects of exercise.

scientific article published on 26 April 2012

α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation

scientific article published on 4 January 2011

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction

scientific article published on 01 December 2018

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