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List of works by Ikuo Tooyama

2-buten-4-olide, an endogenous feeding suppressant, improves spatial performance through brain acidic fibroblast growth factor in mice

scientific article published in December 2001

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

scientific article published on 20 October 2020

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease

scientific article (publication date: 4 September 2014)

A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers

scientific article published on 01 January 2000

A single pre-training glucose injection induces memory facilitation in rodents performing various tasks: contribution of acidic fibroblast growth factor

scientific article published in August 1998

Acidic FGF expression in the surroundings of senile plaques

scientific article published on 01 November 1994

Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease

scientific article

Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients

scientific article published in January 1991

Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction

scientific article published on 01 November 1994

Actions of acidic fibroblast growth factor fragments on food intake in rats

scientific article published on 01 December 1995

Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum

scientific article published on 29 September 2017

Age-related modulation of γ-secretase activity in non-human primate brains.

scientific article published on 14 August 2012

Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).

scientific article

Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons

scientific article

Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve

scientific article

BNP signaling is crucial for embryonic stem cell proliferation

BNP signaling is crucial for embryonic stem cell proliferation

scientific article

C-type natriuretic peptide-like immunoreactivity in the rat inner ear

scientific article published on 01 January 2000

CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions.

scientific article published on January 2015

Characterization of a Novel Monoclonal Antibody against Human Mitochondrial Ferritin and Its Immunohistochemical Application in Human and Monkey Substantia Nigra.

scientific article published on 23 February 2017

Choline acetyltransferase immunopositive neurons in the lateral septum

scientific article published in November 1990

Co-expression pattern of neuronal nitric oxide synthase and two variants of choline acetyltransferase in myenteric neurons of porcine ileum

scientific article published in March 2004

Columnar arrangement of beta-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease

scientific article published in January 1993

Comparison of FGF1 (aFGF) expression between the dorsal motor nucleus of vagus and the hypoglossal nucleus of rat

scientific article published on 28 February 2006

Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease

scientific article published on 17 February 2012

Correlation of the expression level of C1q mRNA and the number of C1q-positive plaques in the Alzheimer Disease temporal cortex. analysis of C1q mrna and its protein using adjacent or nearby sections

scientific article

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

scientific article

Curcuminoid binds to amyloid-β1-42 oligomer and fibril

scientific article published on 01 January 2011

DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats

scientific article published on 19 September 2007

Delayed expression of c-fos protein in rat hippocampus and cerebral cortex following transient in vivo exposure to hypoxia

scientific article

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

scientific article

Detection of viral DNA in the endolymphatic sac in Ménière's disease by in situ hybridization

scientific article published on 01 May 2003

Distinct localization of peripheral and central types of choline acetyltransferase in the rat cochlea

scientific article published on 23 October 2013

Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons.

scientific article published on 19 June 2008

Distribution of taurine-like immunoreactivity in the mouse liver during ontogeny and after carbon tetrachloride or phenobarbital intoxication

scientific article published on 01 May 1993

Early response of brain resident microglia to kainic acid-induced hippocampal lesions

scientific article

Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model

scientific article published on 18 April 2012

Effective magnetic labeling of transplanted cells with HVJ-E for magnetic resonance imaging

scientific article published in March 2004

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

scientific article published on 21 September 2016

Effects of an acidic fibroblast growth factor fragment analog on learning and memory and on medial septum cholinergic neurons in senescence-accelerated mice

scientific article

Effects of fibroblast growth factors and platelet-derived growth factor on food intake in rats

scientific article

Effects of fibroblast growth factors and related peptides on food intake by rats

scientific article published on 01 August 1994

Effects of neopterin on ischemic neuronal damage in gerbils

scientific article published in May 1994

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

scientific article

Expression Profiles of Cytokines in the Brains of Alzheimer's Disease (AD) Patients Compared to the Brains of Non-Demented Patients with and without Increasing AD Pathology ⬇️

scientific article published on January 1, 2011

Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina ⬇️

scientific article published on December 13, 2011

Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex

scientific article

Expression of NPR-B in neurons of the dorsal root ganglia of the rat.

scientific article published on 27 February 2013

Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat.

scientific article published on January 2003

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

scientific article published in January 1993

Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina.

scientific article

Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.

scientific article

Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake

scientific article published in February 1996

Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil

scientific article published in January 2007

Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice

scientific article

Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease.

scientific article published on 28 October 2016

Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism

scientific article published on July 2005

Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body

scientific article published on 25 April 2016

Genetic risk factors for Alzheimer's disease

scientific article published in January 2004

Glutaminergic neurotransmission in Alzheimer's disease

scientific article published in October 2011

High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain

scientific article published in October 1992

High-dose ketamine does not induce c-Fos protein expression in rat hippocampus

scientific article published in March 1993

Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction

scientific article published on 4 January 2012

Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals.

scientific article

Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia

scientific article

Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes

scientific article published on 15 February 2018

Immunohistochemical Localization of an Isoform of TRK-Fused Gene-Like Protein in the Rat Retina.

scientific article

Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem.

scientific article published on 11 February 2012

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.

scientific article

Immunohistochemical demonstration of [D-Ala2]deltorphin-I in amacrine cells of rat retina

scientific article published on 01 January 1994

Immunohistochemical demonstration of choline acetyltransferase of a peripheral type (pChAT) in the enteric nervous system of rats

scientific article

Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1.

scientific article published in May 1994

Immunohistochemical localization of GABAA receptors in comparison with GABA-immunoreactive structures in the nucleus tractus solitarii of the rat.

scientific article published in February 1998

Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx

scientific article published on 01 September 1999

Immunohistochemical localization of glucose transporters (GLUT1 and GLUT3) in the rat hypothalamus

scientific article published on 01 December 1995

Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis.

scientific article published on 9 February 2007

Immunohistochemical study of A2B5-positive ganglioside in postmortem human brain tissue of Alzheimer disease, amyotrophic lateral sclerosis, progressive supranuclear palsy and control cases

scientific article

Immunohistochemical study of TAFII250 in the rat laryngeal nervous system

scientific article published on 01 October 2005

Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain

scientific article published in January 1993

Immunoreactive neurons in the brain of two mouse strains after incubation with an antiserum recognizing Asp-Val-Val-Gly.NH2 (DVVG), the C-terminal fragment of (D-Ala2)-deltorphin I.

scientific article published in September 2002

Immunoreactivity for Choline Acetyltransferase of Peripheral-Type (pChAT) in the Trigeminal Ganglion Neurons of the Non-Human Primate Macaca fascicularis

scientific article published on 23 March 2013

In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens).

scientific article

In vivo detection of amyloid β deposition using ¹⁹F magnetic resonance imaging with a ¹⁹F-containing curcumin derivative in a mouse model of Alzheimer's disease

scientific article published on 12 April 2011

In vivo detection of copper ions by magnetic resonance imaging using a prion-based contrast agent

scientific article published on 19 July 2012

In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801.

scientific article published in June 1997

In vivo hypoxia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus

scientific article published in July 1997

Increased expression of hippocampal cholinergic neurostimulating peptide-related components and their messenger RNAs in the hippocampus of aged senescence-accelerated mice

scientific article published in January 1999

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice

scientific article published on 01 October 2010

Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease

scientific article

Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase

scientific article published in April 2004

Insulin receptor mRNA in the substantia nigra in Parkinson's disease

scientific article published in February 1996

Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus

scientific article published in February 1999

Isolation of glutamyltaurine from bovine brains and proof of its gamma-linkage by the B/E linked scan SIMS technique

scientific article published in September 1990

Kainic acid induces expression of caveolin-1 in activated microglia in rat brain

scientific article published in January 2013

Kainic acid induction of heme oxygenase in vivo and in vitro

scientific article published in August 1998

Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation

scientific article

Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse

scientific article published in October 1998

Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

scientific article published on 11 December 2013

Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord

scientific article published on 2 December 2016

Localization of fibroblast growth factor-1 in cholinergic neurons innervating the rat larynx

scientific article

Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease

scientific article

Low expression of FGF1 (fibroblast growth factor-1) in rat parasympathetic preganglionic neurons

scientific article published on 01 December 2007

Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder

scientific article published on 01 February 1995

MR tracking of transplanted glial cells using poly-L-lysine-CF3.

scientific article published on 8 August 2006

Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain.

scientific article published on 18 November 2005

Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis.

scientific article published in April 2011

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis

scientific article published on 28 April 2016

Microglia in degenerative neurological disease.

scientific article published on January 1993

Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin

scientific article published on 23 July 2019

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats

scientific article

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.

scientific article published on 12 August 2016

Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression

scientific article published on 2 February 2017

Molecular cloning of BNP from heart and its immunohistochemical localization in the hypothalamus of monkey

scientific article published on 9 February 2006

Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy.

scientific article published in January 2002

Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease

scientific article published in December 1993

Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease

scientific article published on 25 June 2011

Mouse brain IgG-like immunoreactivity: strain-specific occurrence in microglia and biochemical identification of IgG.

scientific article published in November 2005

Multiple cytokines are involved in the early events leading to the Alzheimer's disease pathology

scientific article

NPR-A regulates self-renewal and pluripotency of embryonic stem cells ⬇️

scientific article published on March 10, 2011

NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina

scientific article published on 28 October 2009

NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels.

scientific article

New proteomic insights on the role of NPR-A in regulating self-renewal of embryonic stem cells

scientific article published on August 2014

Novel curcumin derivatives as potent inhibitors of amyloid β aggregation

scientific article published on 26 October 2015

Ontogeny of (D-Ala(2))-deltorphin I-like immunoreactive neurones in foetal rat brain

scientific article published on 01 February 2000

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains

scientific article published on 20 January 2020

Phylogenetic and ontogenetic study of neuropeptide Y-containing nerves in the liver

scientific article published in May 1994

Phylogenetic study of serotonin-immunoreactive structures in the pancreas of various vertebrates

scientific article published in February 1991

Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons

scientific article published in January 1995

Postnatal development of [D-Ala2]deltorphin-I-like immunoreactive structures in the rat brain

scientific article published in November 1994

Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain

scientific article

Presence of mRNA for vasoactive intestinal polypeptide (VIP) and its receptor in the rat inner ear.

scientific article

Production and immunohistochemical application of antiserum against Tyr-D-Ala-Phe, a N-terminal tripeptide common to dermorphin/deltorphin family

scientific article published on 01 November 2000

Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain

scientific article published in January 1991

Production of monoclonal antibody against histamine and its application to immunohistochemical study in the stomach.

scientific article published on June 1998

Production of monoclonal antibody to deltorphin-I and its immunocytochemical application to adult rat brain and cultured rat brain neurons

scientific article published on 01 November 2000

Proton magnetic resonance spectroscopy assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls

scientific article published on 31 January 2017

RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear.

scientific article published in March 1998

Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.

scientific article published on 17 January 2005

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

scientific article published in July 1990

Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism

scientific article published on 23 January 2007

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease

scientific article published on 23 February 2010

Response to fish specific reproductive hormones and endocrine disrupting chemicals of a Sertoli cell line expressing endogenous receptors from an endemic cyprinid Gnathopogon caerulescens ⬇️

scientific article published on June 13, 2013

Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in Parkinson's disease

scientific article published on 01 September 1994

S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.

scientific article published on 18 November 2015

Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.

scientific article published on 03 January 2017

Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5

scientific article published in PLoS ONE

Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain

scientific article

Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.

scientific article published on 11 July 2016

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.

scientific article

The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.

scientific article

The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.

scientific article published on 29 September 2006

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases

scientific article published on 08 December 2020

Time course of in vitro expression of NADPH-diaphorase in cultured rat brain neurons: comparison with in vivo expression

scientific article

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice.

scientific article published on October 2016

Transition metal abnormalities in progressive dementias.

scientific article published on 12 November 2011

Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging

scientific article

Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters

scientific article published in April 1999

UBR5 Gene Mutation Is Associated with Familial Adult Myoclonic Epilepsy in a Japanese Family ⬇️

scientific article published on September 17, 2012

Upregulation of mitochondrial ferritin by proinflammatory cytokines: implications for a role in Alzheimer's disease.

scientific article

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan

scientific article published on 7 August 2006

Visualizing hepatic copper release in Long-Evans cinnamon rats using single-photon emission computed tomography

scientific article published on 5 May 2013

Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions

scientific article published on 13 September 2017

[Dystonia update]

scientific article published on 01 November 2006

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior

scientific article

β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway

scientific article published on 18 April 2013

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