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List of works by Judith Haendeler

A New Kid on the Block

scientific article published on 01 October 2008

Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).

scientific article published on August 2014

Aging-mechanisms, models, and translation

scientific article published in October 2013

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

scientific article published on 01 May 2000

Angiotensin II mediated signal transduction. Important role of tyrosine kinases.

scientific article

Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis

scientific article (publication date: 2002)

Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins

scientific article

Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

scientific article published on 12 February 2004

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.

scientific article published on 21 June 2018

Caffeine enhances endothelial repair by an AMPK-dependent mechanism

scientific article published on 28 August 2008

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation

scientific article published on 10 December 2012

Cathepsin D and H2O2 stimulate degradation of thioredoxin-1: implication for endothelial cell apoptosis

scientific article published on November 2005

Cell-to-Cell Connection of Endothelial Progenitor Cells With Cardiac Myocytes by Nanotubes

scientific article published on 05 May 2005

Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase--potential role in senescence and aging

scientific article published on 28 February 2014

Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1.

scientific article published on 22 April 2008

Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions

scientific article published on 01 July 1998

Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol

scientific article published on 01 December 2000

Critical regulators of endothelial cell functions: for a change being alternative.

scientific article published on 14 October 2014

Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin

scientific article published on 12 March 2002

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

scientific article published on June 1999

Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E-cadherin

scientific article published on 06 October 2005

Do We Age on Sirt1 Expression?

scientific article published on 01 May 2007

Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells.

scientific article

Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent

scientific article published on 06 March 2010

Effects of Granulocyte Colony Stimulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients With Chronic Ischemic Heart Disease

scientific article published on 10 August 2006

Effects of redox-related congeners of NO on apoptosis and caspase-3 activity

scientific article published on August 1997

Endothelial Cells in Health and Disease

article

Endothelial NADPH oxidase 2: when does it matter in atherosclerosis?

scientific article published on 23 February 2012

Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells

scientific article published on 13 September 2007

Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism

scientific article published in October 2002

GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor ⬇️

scientific article (publication date: 12 December 2003)

GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions

scientific article (publication date: 30 April 2004)

Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt

scientific journal article

Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration

scientific article published on 22 September 2008

Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death

scientific article published on 01 October 2000

HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes

scientific article published on 3 April 2003

High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

scientific article published on 10 June 2019

Highlight: Oxidative Stress and Senescence

scientific article published on 01 March 2008

Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

scientific article published on July 2003

Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells

scientific article published on July 2002

Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease

scientific article published on 27 October 2005

Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts

scientific article published on 21 June 2018

Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells

scientific article published on 23 November 2018

Inhibition of suicidal erythrocyte death by nitric oxide.

scientific article published on 6 December 2007

Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

scientific article published on May 2010

Inseparably tied: functional and antioxidative capacity of endothelial progenitor cells

scientific article published in February 2006

Interacting with thioredoxin-1--disease or no disease?

scientific article published on 24 September 2012

Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules.

scientific article published on 25 June 2017

Intra- and Interorgan Communication in the Cardiovascular System: A Special View on Redox Regulation

scientific article published on 10 January 2017

Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression

scientific article published on November 2004

Measurement of endothelium-dependent vasodilation in mice--brief report.

scientific article published on 23 October 2014

Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage

scientific article published on 5 March 2009

Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase.

scientific article published on October 2007

Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations.

scientific article published on 14 July 2017

Nitric Oxide Inhibits Caspase-3 byS-Nitrosationin Vivo

scientific article published on 01 March 1999

Nitric oxide and apoptosis

scientific article

Nitric oxide down-regulates MKP-3 mRNA levels: involvement in endothelial cell protection from apoptosis

scientific article

Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles.

scientific article published on 23 April 2018

Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells

scientific article

Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart

scientific article

Nuclear Redox-Signaling Is Essential for Apoptosis Inhibition in Endothelial Cells—Important Role for Nuclear Thioredoxin-1

scientific article published on 06 September 2007

Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.

scientific article published on October 2008

Nuclear redox signaling

scientific article published on March 2010

Oxidative Stress–Induced Degradation of Thioredoxin-1 and Apoptosis Is Inhibited by Thioredoxin-1–Actin Interaction in Endothelial Cells

scientific article published on 06 January 2011

Oxidativer Stress im Endothel und bei Diabetes Typ 2

scientific article published on 01 February 2012

Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall.

scientific article

Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis ⬇️

scientific article published on February 17, 2011

Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

scientific article

Redox balance in the aged endothelium.

scientific article published on October 2013

Redox modification of cell signaling in the cardiovascular system

scientific article

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

scientific article

Regulation of endothelial cell apoptosis in atherothrombosis

scientific article

Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation

scientific article (publication date: 11 February 2003)

Role of Telomerase in the Cardiovascular System

scientific article

SIRT1 controls endothelial angiogenic functions during vascular growth

scientific article published on October 2007

Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction

scientific article published in September 2003

Shear stress inhibits apoptosis of human endothelial cells

scientific article published on 01 December 1996

Silver ion-induced suicidal erythrocyte death.

scientific article published in August 2009

Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor

scientific article

Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells.

scientific article published in November 2004

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

scientific article published on February 1997

TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells

scientific article published on 27 August 2001

Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction.

scientific article

The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1.

scientific article

The aryl hydrocarbon receptor promotes aging phenotypes across species.

scientific article published on 21 January 2016

The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4.

scientific article published on 12 March 2014

The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment

scientific article

The role of near infrared radiation in photoaging of the skin.

scientific article published on 27 April 2008

The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner.

scientific article

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

scientific article

Thioredoxin: a key regulator of cardiovascular homeostasis

scientific article published on November 2003

Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo

scientific article

Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes

scientific article published on 06 April 2012

Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax

scientific article published on 01 December 1996

Well-known signaling proteins exert new functions in the nucleus and mitochondria.

scientific article published on August 2010

Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation

scientific article

c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy

scientific article published on November 2010

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization

scientific article published on 29 January 2004

p38 mitogen-activated protein kinase downregulates endothelial progenitor cells

scientific article published on March 2005

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