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List of works by Nigel Turner

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

scientific article published on 5 August 2013

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

scientific article published on 22 January 2019

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

scientific article published in Nature Communications

ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

scientific article published on 16 September 2013

AMP-activated protein kinase and muscle insulin resistance

scientific article published on January 2009

Ablation of Grb10 specifically in muscle impacts on muscle size and glucose metabolism in mice

scientific article published on 23 January 2018

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ

scientific article

Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice.

scientific article published on 19 June 2012

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake

scientific article

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

scientific article

Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacity

scientific article

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

scientific article published on 17 August 2015

Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of rats

scientific article published on 19 August 2012

Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress.

scientific article published on 18 February 2011

An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance

scientific journal article

An allometric comparison of microsomal membrane lipid composition and sodium pump molecular activity in the brain of mammals and birds.

scientific article published in January 2005

Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway

Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway

scientific article published on March 2008

Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

scientific article published on 27 August 2013

Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains

scientific article published on 24 October 2017

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways.

scientific article

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

scientific article

Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance

scientific article published in March 2006

Cholesterol effect on the dipole potential of lipid membranes

scientific article

Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle

scientific article published on 27 September 2013

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

scientific article

Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role?

scientific article

Diabetes and its link with cancer: providing the fuel and spark to launch an aggressive growth regime.

scientific article published on 15 April 2015

Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

scientific article

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle

scientific journal article

Disparate metabolic response to fructose feeding between different mouse strains

scientific article

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

scientific article published on 26 April 2013

Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism.

scientific article published on 10 October 2003

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

scientific article published in December 2017

Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus

scientific article published on 11 July 2017

Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity

scientific article published on February 2014

Electric field strength of membrane lipids from vertebrate species: membrane lipid composition and Na+-K+-ATPase molecular activity.

scientific article published on 11 November 2004

Enhanced peroxisomal β-oxidation is associated with prevention of obesity and glucose intolerance by fish oil-enriched diets

scientific article published on 13 May 2013

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids

scientific article published on 31 August 2009

Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma

scientific article published on 17 October 2016

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

scientific article published on 22 May 2007

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

scientific article published on 18 June 2004

Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans

scientific article

FOX01 Is the Headline Akt Regulating Hepatic Glucose Metabolism.

scientific article

Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment ⬇️

scientific article published on 04 July 2016

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

scientific article published on 15 January 2014

Fatty acid relationships in former cannabis users with schizophrenia

scientific article published on 19 October 2005

Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle.

scientific article published on 5 March 2018

Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

scientific article published on December 2006

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

scientific article

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

scientific article published on 04 September 2007

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation

scientific article published on November 2014

Grb10 regulates the development of fiber number in skeletal muscle

article

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

scientific article published on 21 November 2003

High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation

scientific article

High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice

scientific article

How might you compare mitochondria from different tissues and different species?

scientific article published on 12 January 2006

IRS1-independent defects define major nodes of insulin resistance

scientific article

Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors

scientific article published on January 2012

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

scientific article

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

scientific article published in March 2018

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging

scientific article published on 01 February 2019

Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats

scientific article published in Scientific Reports

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

scientific article

Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase

scientific article published on 19 February 2009

Insulin resistance is a cellular antioxidant defense mechanism

scientific article

Is mitochondrial dysfunction a cause of insulin resistance?

scientific article published on 17 September 2008

Limits to physical performance and metabolism across species.

scientific article published on November 2006

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

scientific article published on 14 April 2009

Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).

scientific article published on 30 April 2013

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

scientific article published on 4 April 2016

Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects.

scientific article published on 23 January 2007

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice

scientific article published on 14 December 2015

Mitochondrial dysfunction and insulin resistance: an update

scientific article

Mitochondrial mutations and metabolic adaptation in pancreatic cancer.

scientific article published on 30 January 2017

Mitochondrial stress signaling promotes cellular adaptations

scientific article

Modelling insulin resistance in rodents by alterations in diet. What have "high fat" and high calorie diets revealed?

scientific article published on 7 November 2017

Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics

scientific article

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

scientific article published on 20 February 2013

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction

scholarly article

NAD(+) : a key metabolic regulator with great therapeutic potential

scientific article

NF1 is a critical regulator of muscle development and metabolism

scientific article

New insight into the mechanism by which acute physical exercise ameliorates insulin resistance

scholarly article by Andrew J. Hoy & Nigel Turner published 1 May 2008 in Journal of Physiology

Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes

scientific article

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

scientific article

Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance

scientific article

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

scientific article published on 19 December 2006

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

scientific article published on 10 December 2008

Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle

scientific article

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

scientific article

Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo.

scientific article published on 9 March 2010

Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans

scientific article

PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis

scientific article

PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle

scientific article

Peripheral neuropeptide Y Y1 receptors regulate lipid oxidation and fat accretion

scientific article published on 17 November 2009

Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.

scientific article

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice

scientific article published on May 2012

Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.

scientific article published in June 2012

Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice

article

Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression.

scientific article

Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds

scientific article published in December 2003

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling

scientific article published on 12 April 2019

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

scientific article published on 31 August 2016

Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney

scientific article

Repurposing Drugs to Target the Diabetes Epidemic

scientific article published on 18 February 2016

Respiration rate of hepatocytes varies with body mass in birds

scientific article published on June 2004

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

scientific article published on 16 September 2004

Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts.

scientific article

Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells

scientific article published on 08 June 2019

Sodium pump molecular activity and membrane lipid composition in two disparate ectotherms, and comparison with endotherms

article

The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice

scientific article published on 21 October 2014

The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

scientific article published on 22 December 2009

The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway

scientific article

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

scientific article

The effect of α-actinin-3 deficiency on muscle aging

scientific article published on 26 November 2010

The evolution of endothermy: role for membranes and molecular activity.

scientific article

The evolution of insulin resistance in muscle of the glucose infused rat

scientific article

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice

scientific article

The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice

scientific journal article

The role of mitochondrial sirtuins in health and disease

scientific article published on 6 May 2016

The role of oxysterol-binding protein and its related proteins in cancer

scientific article

The synthesis of sub-micron magnetic particles and their use for preparative purification of proteins

scientific article published on 01 November 1998

The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle.

scientific article

The ω-3 and ω-6 fats in meals: a proposal for a simple new label.

scientific article

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

scientific article

Using the Human Genome-Scale Metabolic Model Recon 2 for Steady-State Flux Analysis of Cancer Cell Metabolism

scientific article published on 01 January 2019

Why are some mitochondria more powerful than others: insights from comparisons of muscle mitochondria from three terrestrial vertebrates.

scientific article published in October 2005

Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity

scientific article published in December 2010

α-Actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle

article

βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells

scientific article published on 4 May 2016

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