List of works - Maria Regina D'Império Lima

Activation of CD4+ and CD8+ parasite -specific T-cells by macrophages infected with live T. Cruzi amastigotes

scientific article published on 01 September 1998

Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice.

scientific article

Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease

scientific article

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice

scientific article published on 10 February 2022

CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria

scientific article published in PLoS ONE

Cellular renewal and improvement of local cell effector activity in peritoneal cavity in response to infectious stimuli

scientific article

Chagas disease: still many unsolved issues

scientific article published on 29 June 2014

Challenge of Trypanosoma cruzi chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels

scientific article

Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine.

scientific article published on 19 December 2012

Characterization of the spleen B-cell compartment at the early and late blood-stage Plasmodium chabaudi malaria

scientific article

Comparative analysis of activation phenotype, proliferation, and IFN-gamma production by spleen NK1.1(+) and NK1.1(-) T cells during Plasmodium chabaudi AS malaria

scientific article

Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi

scientific article

Correction: CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria

scientific article published on 25 March 2019

Early skin immunological disturbance after Plasmodium-infected mosquito bites

scientific article published in May 2012

Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.

scientific article published in December 2008

Granulocytic Myeloid-Derived Suppressor Cells Aggravate Tuberculosis Caused by Hypervirulent Mycobacteria

scientific article published on 18 November 2020

Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-γ.

scientific article published on 20 August 2016

IFN-γ Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases

scientific article

IFN-γ-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria

scientific article published on 16 October 2013

IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction

scientific article

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria

scientific article published on 20 May 2019

Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice

scientific article published in December 2002

In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria

scientific article

Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

scientific article published on 04 August 2009

Influence of the polyclonal activation induced by Plasmodium chabaudi on ongoing OVA-specific B- and T-cell responses

scientific article published in October 2002

Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis

article

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

scientific article

Interferon-gamma reduces the proliferation of M. tuberculosis within macrophages from a patient with a novel hypomorphic NEMO mutation.

scientific article published on 8 July 2016

Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune-protected mice

scientific article published in May 1987

Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses

scientific article (publication date: 2013)

Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators

scientific article published on 20 March 2012

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

scientific article

Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile.

scientific article published in February 2002

Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules.

scientific article

MyD88 signaling is directly involved in the development of murine placental malaria

scientific article published on 09 December 2013

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

scientific article

Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi

scientific article published on 17 November 2009

Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection

scientific article

P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis.

scientific article

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

scientific article

P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis

scientific article published on 05 May 2021

Pathogenic Mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages

scientific article

Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas' disease

scientific article published on April 2004

Plasmodium chabaudi chabaudi: a monoclonal antibody raised against soluble antigens present in the plasma of infected mice recognizes a 250-kDa schizont glycoprotein that is secreted during schizogony.

scientific article

Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

scientific article

Programmed Cell Death Protein 1-PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection.

scientific article

Publisher Correction: TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria.

scientific article

Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis

scientific article

Purification of F(ab′)2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with high neutralization activity, purity and yield

scholarly article by M C dos Santos et al published January 1989 in Toxicon

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis

scientific article published on 18 May 2017

Revisiting mouse peritoneal macrophages: heterogeneity, development, and function

scientific article

Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria

scientific article published in January 2005

Role of Membrane-Bound IgM in Trypanosoma cruzi Evasion from Immune Clearance

article by Isabela E. Garcia et al published April 1997 in Journal of Parasitology

Role of endogenous IFN-gamma in macrophage programming induced by IL-12 and IL-18.

scientific article

Splenic Macrophage Subsets and Their Function during Blood-Borne Infections

scientific article

Susceptibility of the different developmental stages of the asexual (schizogonic) erythrocyte cycle of Plasmodium chabaudi chabaudi to hyperimmune serum, immunoglobulin (Ig)G1, IgG2a and F(ab')2 fragments

scientific article published in November 2001

T cell-specific P2RX7 favors lung parenchymal CD4<sup>+</sup> T cell accumulation in response to severe lung infections

TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria

scientific article published on 17 August 2017

Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice.

scientific article

The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom

scientific article published on 05 March 2013

The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice.

scientific article

The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom

scientific article published on 21 April 2016

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

scientific article

The spleen CD4+ T cell response to blood-stage Plasmodium chabaudi malaria develops in two phases characterized by different properties

scientific article

Tuberculosis in an autosomal recessive case of chronic granulomatous disease due to mutation of the NCF1 gene.

scientific article published on 22 September 2015

Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome.

scientific article published on 13 June 2014

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

scientific article published on May 2004

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

scholarly article by K BASTOS et al published May 2004 in Microbes and Infection

List of works by Maria Regina D'Império Lima

Activation of CD4+ and CD8+ parasite -specific T-cells by macrophages infected with live T. Cruzi amastigotes

Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice.

Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice

CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria

Cellular renewal and improvement of local cell effector activity in peritoneal cavity in response to infectious stimuli

Chagas disease: still many unsolved issues

Challenge of Trypanosoma cruzi chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels

Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine.

Characterization of the spleen B-cell compartment at the early and late blood-stage Plasmodium chabaudi malaria

Comparative analysis of activation phenotype, proliferation, and IFN-gamma production by spleen NK1.1(+) and NK1.1(-) T cells during Plasmodium chabaudi AS malaria

Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi

Correction: CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria

Early skin immunological disturbance after Plasmodium-infected mosquito bites

Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.

Granulocytic Myeloid-Derived Suppressor Cells Aggravate Tuberculosis Caused by Hypervirulent Mycobacteria

Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-γ.

IFN-γ Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases

IFN-γ-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria

IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria

Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice

In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria

Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Influence of the polyclonal activation induced by Plasmodium chabaudi on ongoing OVA-specific B- and T-cell responses

Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

Interferon-gamma reduces the proliferation of M. tuberculosis within macrophages from a patient with a novel hypomorphic NEMO mutation.

Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune-protected mice

Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses

Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile.

Most parasite-specific CD8+ cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules.

MyD88 signaling is directly involved in the development of murine placental malaria

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi

Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection

P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis

Pathogenic Mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages

Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas' disease

Plasmodium chabaudi chabaudi: a monoclonal antibody raised against soluble antigens present in the plasma of infected mice recognizes a 250-kDa schizont glycoprotein that is secreted during schizogony.

Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

Programmed Cell Death Protein 1-PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection.

Publisher Correction: TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria.

Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis

Purification of F(ab′)2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with high neutralization activity, purity and yield

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis

Revisiting mouse peritoneal macrophages: heterogeneity, development, and function

Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria

Role of Membrane-Bound IgM in Trypanosoma cruzi Evasion from Immune Clearance

Role of endogenous IFN-gamma in macrophage programming induced by IL-12 and IL-18.

Splenic Macrophage Subsets and Their Function during Blood-Borne Infections

Susceptibility of the different developmental stages of the asexual (schizogonic) erythrocyte cycle of Plasmodium chabaudi chabaudi to hyperimmune serum, immunoglobulin (Ig)G1, IgG2a and F(ab')2 fragments

T cell-specific P2RX7 favors lung parenchymal CD4<sup>+</sup> T cell accumulation in response to severe lung infections

TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria

Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice.

The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom

The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice.

The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

The spleen CD4+ T cell response to blood-stage Plasmodium chabaudi malaria develops in two phases characterized by different properties

Tuberculosis in an autosomal recessive case of chronic granulomatous disease due to mutation of the NCF1 gene.

Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome.

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?