Search filters

List of works by José J. Lucas

A mouse model to study tau pathology related with tau phosphorylation and assembly

scientific article published on 23 March 2007

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease

scientific article published on 02 May 2021

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

scientific article published on 30 July 2009

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

scientific article published in March 2010

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

scientific article published on 6 July 2012

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

scientific article published on 29 October 2015

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

scientific article published on 26 January 2009

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

scientific article

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

scientific article

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

scientific article published in October 2004

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures

scientific article published on 29 January 2013

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

scientific article published in January 2010

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

scientific article published on 24 October 2006

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

scientific article published on 27 July 2005

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

scientific article published on 16 June 2015

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

scientific article

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.

scientific article published on 21 May 2009

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

scientific article published in January 2004

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

scientific article published on 01 December 2001

Faulty splicing and cytoskeleton abnormalities in Huntington's disease

scientific article published on 16 August 2016

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

scientific article

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

scientific article

GSK3 and tau: two convergence points in Alzheimer's disease.

scientific article published on January 2013

GSK3: a possible link between beta amyloid peptide and tau protein.

scientific article published on 24 September 2009

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

scientific article

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

scientific article

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease

scientific article published on 5 November 2003

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.

scientific article

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

scientific article published on 01 April 2021

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

scientific article published on 20 July 2014

Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors

scientific article published on 01 August 2021

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.

scientific article published on 21 August 2010

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice

scientific article published on 14 December 2015

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases.

scientific article

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.

scientific article

Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease

scientific article published in January 2011

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

scientific article published on May 1998

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

scientific article published on 19 June 2006

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.

scientific article

Is the ubiquitin-proteasome system impaired in Huntington's disease?

scientific article published on September 2007

Looking for novel functions of tau.

scientific article published on August 2012

Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's disease

scientific article

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

scientific article published on 7 October 2010

MAP2 Splicing is Altered in Huntington's Disease.

scientific article published on 21 April 2016

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus

scientific article published on 15 August 2014

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders

scientific article

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.

scientific article

Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

scientific article published on 01 April 1993

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes

scientific article

N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation

scientific article published on 14 June 2007

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

scientific journal article

Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent

scientific article

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.

scientific article published on 17 May 2007

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

scientific article published in July 2002

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

scientific article

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

scientific article

Pathogenic Mis-splicing of CPEB4 in Schizophrenia

scientific article published in 2023

Peripheral noxious stimulation induces CREM expression in dorsal horn: involvement of glutamate

scientific article published on 01 December 1997

Presynaptic dysfunction in Huntington's disease.

scientific article published on April 2010

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system

scientific article published on 8 December 2015

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

scientific article

Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism

scientific article published on August 2010

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

scientific article published on 4 September 2009

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

scientific article published in February 2006

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice

scientific article published on 21 July 2014

Regulation of proteasome activity by P2Y2 receptor underlies the neuroprotective effects of extracellular nucleotides.

scientific article published on 18 October 2016

Role of tau protein in both physiological and pathological conditions.

scientific article published on April 2004

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments

scientific article published in December 2002

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

scientific article published on 24 February 2017

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity

scientific article (publication date: June 2011)

Sulfo-glycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs

scientific article

Tau kinase I overexpression induces dentate gyrus degeneration

scientific article

Tau phosphorylation in hippocampus results in toxic gain-of-function.

scientific article published on August 2010

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

scientific article published on 11 December 2009

Tau-positive nuclear indentations in P301S tauopathy mice.

scientific article published on 24 June 2016

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

scientific article

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

scientific article published on February 2004

The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease

scientific article

The role of GSK3 in Alzheimer disease.

scientific article published on 27 May 2009

The ubiquitin-proteasome system in Huntington's disease.

scientific article

Ubiquitin-proteasome system involvement in Huntington's disease

scientific article published in 2014

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.

scientific article

Paulina is supported by:

About Paulina

Help