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Authors whose works are in public domain in at least one jurisdiction

List of works by Edward J Bilsky

14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects

scientific article

6beta-naltrexol preferentially antagonizes opioid effects on gastrointestinal transit compared to antinociception in mice

scientific article

6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists

scientific article

6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study

scientific article

Antinociceptive actions of BW373U86 in the mouse

scientific article published on 01 November 1993

Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs

scientific article published on 01 April 2000

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides

scientific article

Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.

scientific article

Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence

scientific article published on 4 November 2003

Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand

scientific article

Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys

scientific article published on 29 May 2008

Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.

scientific article published on 16 July 2013

CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences

scientific article published in January 1998

Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?

scientific article published on 07 March 2014

Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo.

scientific article

Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor

scientific article published on 29 June 2005

Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole

scientific article published in August 1992

Cocaine self-administration and naltrindole, a delta-selective opioid antagonist

scientific article published in July 1995

Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice

scientific article

Differential effects of MK-801 on cerebrocortical neuronal injury in C57BL/6J, NSA, and ICR mice

scientific article published in August 2000

Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice

scientific article published on 01 April 1996

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

scientific article published on July 1994

Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.

scientific article

Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice

scientific article

Glycosylation improves the central effects of DAMGO.

scientific article published on January 2007

Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor

scientific article

Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

scientific article

In vitro and in vivo assessment of mu opioid receptor constitutive activity

scientific article published on January 2010

In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice

scientific article published on 16 February 2005

In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice

scientific article

In vivo characterization of the opioid antagonist nalmefene in mice

scientific article

In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.

scientific article

Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.

scientific article published in June 2001

K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience

scientific article

MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference

scientific article published in June 1991

MDMA produces a conditioned place preference and elicits ejaculation in male rats: a modulatory role for the endogenous opioids

scientific article published in October 1991

Manipulations of the renin-angiotensin system and intake of a sweetened alcoholic beverage among rats

scientific article published in January 1992

Methylenedioxymethamphetamine's capacity to establish place preferences and modify intake of an alcoholic beverage

scientific article published in December 1990

Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats: implications for preclinical behavioral assessment of chronic pain

scientific article

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

scientific article

Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors

scientific article

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

scientific article published on 29 September 2013

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists

scientific article

Opioid receptor types and subtypes: the delta receptor as a model.

scientific article published on January 1996

Opioidergic modulation of cocaine conditioned place preferences

scientific article published in January 1992

Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments.

scientific article

Preclinical assessment of candidate analgesic drugs: recent advances and future challenges.

scientific article

Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist

scientific article (publication date: 8 July 1994)

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethy

scientific article published on 11 July 2007

Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia

scientific article published in January 2010

Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts.

scientific article published on February 1995

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics ⬇️

scientific article published on March 23, 2011

SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist

scientific article

Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity

scientific article published on 6 July 2011

Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide.

scientific article

Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor

scientific article

Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance

scientific article published in December 2005

Structural Requirements for CNS Active Opioid Glycopeptides.

scientific article

Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans

scientific article published in September 1999

Targeting Pain-Suppressed Behaviors in Preclinical Assays of Pain and Analgesia: Effects of Morphine on Acetic Acid-Suppressed Feeding in C57BL/6J Mice

scientific article published on 01 June 2006

Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.

scientific article published on 24 June 2009

Tests of opioid deficiency hypotheses of alcoholism ⬇️

scientific article published on July 1, 1991

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

scientific article

Treatment with antisense oligodeoxynucleotide to a conserved sequence of opioid receptors inhibits antinociceptive effects of delta subtype selective ligands

scientific article

Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta 2-agonist antinociception

scientific article

Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference

scientific article

[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity

scientific article

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