List of works - Mikael Simons

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons

scientific article

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

scientific article

A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets

scientific article published in September 2011

A unified cell biological perspective on axon-myelin injury

scientific article published on August 2014

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

scientific article

Actomyosin contractility controls cell surface area of oligodendrocytes

scientific article published on 25 September 2009

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

scientific article published on January 1999

Age-related myelin degradation burdens the clearance function of microglia during aging.

scientific article published on 13 June 2016

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

scientific article published in February 1996

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

scientific article published on January 2017

Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins

Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains

scientific article published on October 2000

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2

scientific article

Axonal selection and myelin sheath generation in the central nervous system ⬇️

scientific article published on May 24, 2013

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

scientific article published in December 2017

Catching filopodia: Exosomes surf on fast highways to enter cells

scientific article

Cell polarity in myelinating glia: from membrane flow to diffusion barriers

scientific article published on 28 January 2012

Cell type- and brain region-resolved mouse brain proteome.

scientific article published on 2 November 2015

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations

scientific article

Central nervous system myelin: structure, synthesis and assembly

scientific article published on 18 July 2011

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

scientific article published on February 2014

Cholesterol and myelin biogenesis

scientific article published on January 2010

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons ⬇️

scientific article published on May 26, 1998

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

scientific article published on 14 June 2006

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

scientific article

Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies

scientific article published on September 2010

Control of oligodendroglial cell number by the miR-17-92 cluster

scientific article

Defective cholesterol clearance limits remyelination in the aged central nervous system

scientific article published on 4 January 2018

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

scientific article published on 20 February 2021

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

scientific article published on 10 June 2021

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant

scientific article

Editorial overview: Cellular neuroscience

scientific article published in August 2016

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

scientific article

Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice

scientific article published on 9 May 2012

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

scientific article

Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells

scientific article published on October 1999

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

scientific article published on 16 June 2010

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

scientific article published on 19 May 2012

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

scientific article

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

scientific article

Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension

scientific article published on 28 June 2013

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

scientific article published on 24 August 2017

Grey matter myelination

scientific article published on 12 March 2019

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis

scientific article published on 19 October 2004

Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling

scientific article

Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles

scientific article published on 26 October 2010

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

scientific article

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue

scientific article published on 3 January 2017

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila

scientific article

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

scientific article published in February 2012

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

scientific article published on 22 June 2016

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

scientific article published on 24 February 2021

Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system

scientific article published on 4 February 2013

Metabolism and functions of lipids in myelin

scientific article published on 24 December 2014

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

scientific article published on 21 December 2020

Myelin architecture: zippering membranes tightly together

scientific article published on 29 October 2013

Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin

scientific article

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

scientific article (publication date: 2013)

Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

scientific article published on January 2014

Myelination at a glance

scientific article published on July 2014

Myelinophagy: Schwann cells dine in.

scientific article

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

scientific article

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

scientific article

Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

scientific article published on November 2006

Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.

scientific article published on January 1996

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

scientific article published on 20 October 2020

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication

scientific article

Oligodendrocytes: Myelination and Axonal Support

scientific article published on 22 June 2015

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease

scientific article

Palmitoylation is a sorting determinant for transport to the myelin membrane

scientific article published in June 2005

Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.

scientific article

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

scientific article published on 07 November 2020

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence ⬇️

scientific article published on October 16, 1995

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

scientific article published on 12 April 2016

Quantified CSF antibody reactivity against myelin in multiple sclerosis

scientific article published on 9 November 2015

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

scientific article

Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy

scientific article published on June 2016

Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells

scientific article published on 01 March 2007

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

scientific article published in 2011

Self-segregation of myelin membrane lipids in model membranes

scientific article

Subcortical cytoskeleton periodicity throughout the nervous system

scientific article published on 7 March 2016

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

scientific article published in 2021

Targeted ablation of oligodendrocytes triggers axonal damage

scientific article (publication date: 2011)

Tau deposition patterns are associated with functional connectivity in primary tauopathies

scientific article published on 15 March 2022

Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man.

scientific article published on November 2013

The emerging functions of oligodendrocytes in regulating neuronal network behaviour

scientific article

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells

scientific article

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

scientific journal article

The logistics of myelin biogenesis in the central nervous system

scientific article published on 7 February 2017

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

scientific article published on 21 August 2012

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

scientific article published in September 2002

Two-dimensional gel mapping of the processing of the human amyloid precursor protein in rat hippocampal neurons

scientific article published in July 1995

Wrapping it up: the cell biology of myelination

scientific article

List of works by Mikael Simons

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets

A unified cell biological perspective on axon-myelin injury

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

Actomyosin contractility controls cell surface area of oligodendrocytes

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

Age-related myelin degradation burdens the clearance function of microglia during aging.

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins

Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2

Axonal selection and myelin sheath generation in the central nervous system ⬇️

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Catching filopodia: Exosomes surf on fast highways to enter cells

Cell polarity in myelinating glia: from membrane flow to diffusion barriers

Cell type- and brain region-resolved mouse brain proteome.

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations

Central nervous system myelin: structure, synthesis and assembly

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

Cholesterol and myelin biogenesis

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons ⬇️

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies

Control of oligodendroglial cell number by the miR-17-92 cluster

Defective cholesterol clearance limits remyelination in the aged central nervous system

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant

Editorial overview: Cellular neuroscience

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

Grey matter myelination

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis

Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling

Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system

Metabolism and functions of lipids in myelin

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Myelin architecture: zippering membranes tightly together

Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

Myelination at a glance

Myelinophagy: Schwann cells dine in.

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication

Oligodendrocytes: Myelination and Axonal Support

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease

Palmitoylation is a sorting determinant for transport to the myelin membrane

Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence ⬇️

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

Quantified CSF antibody reactivity against myelin in multiple sclerosis

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy

Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells