List of works by Jean-Louis Mergny

"Nano-oddities": unusual nucleic acid assemblies for DNA-based nanostructures and nanodevices

scientific article published on 28 May 2014

"One Ring to Bind Them All"-Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles

scientific article

"One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition

scientific article

1H, 13C, and 15N chemical shift assignments of a G-quadruplex forming sequence within the KRAS proto-oncogene promoter region

scientific article

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

scientific article published on 12 May 2009

8-Amino guanine accelerates tetramolecular G-quadruplex formation.

scientific article

A FRET-based screening assay for nucleic acid ligands.

scientific article

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes.

scientific article published on 13 July 2016

A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells

scientific article

A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity

scientific article published on 01 January 2008

A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity

A directional nucleation-zipping mechanism for triple helix formation

scientific article

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

scientific article published on 12 March 2015

A mirror-image tetramolecular DNA quadruplex

scientific article published on 11 April 2011

A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.

scientific article published on 22 June 2007

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

scientific article published on 08 May 2019

Affinity and selectivity of G4 ligands measured by FRET.

scientific article

Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures

scientific article published on 11 December 2013

Alternative DNA structures: G4 DNA in cells: itae missa est?

scientific article published on 15 February 2012

An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G-Quadruplex Topologies

scientific article published on 02 August 2011

An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex

scientific article published on August 2014

An oxidatively damaged G-quadruplex/hemin DNAzyme

scientific article published on 17 January 2020

Analysis of thermal melting curves.

scientific article published in January 2003

Announcement--the fake meeting society

scientific article published on 01 April 2011

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.

scientific article published on 9 September 2015

Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents

scientific article published on 2 February 2008

Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.

scientific article published on April 2005

Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells

scientific article published on 28 May 2019

Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro.

scientific article

Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures.

scientific article published on 13 January 2014

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay

scientific article published on 14 June 2015

Author Correction: Involvement of G-quadruplex regions in mammalian replication origin activity

scientific article published on 11 June 2020

Author Correction: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand.

scientific article published on 23 May 2019

Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

scientific article

Cationic Pentaheteroaryls as Selective G-Quadruplex Ligands by Solvent-Free Microwave-Assisted Synthesis

scientific article published on 20 September 2012

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

scientific article

Chemical modification of the third strand: differential effects on purine and pyrimidine triple helix formation

scientific article

Combination of i-motif and G-quadruplex structures within the same strand: formation and application.

scientific article published on 14 June 2013

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior

scientific article

Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame.

scientific article

Cooperative 2:1 binding of a bisphenothiazine to duplex DNA.

scientific article

Correction to DNA Quadruple Helices in Nanotechnology

scientific article published on 01 October 2020

DNA Quadruple Helices in Nanotechnology

scientific article published on 03 January 2019

DNA and RNA quadruplex ligands.

scientific article

DNA duplex-quadruplex exchange as the basis for a nanomolecular machine

scientific article

DNA nanomachines and nanostructures involving quadruplexes.

scientific article

DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase

scientific article

DNA structural changes as the basis for a nanomolecular device.

scientific article

DOTASQ as a prototype of nature-inspired G-quadruplex ligand.

scientific article

Design and Structure Determination of a Composite Zinc Finger Containing a Nonpeptide Foldamer Helical Domain

scientific article published on 04 February 2019

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex

scientific article published on 30 December 2017

Design, Synthesis, and Evaluation of 2,9-Bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands.

scientific article published on 04 December 2016

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe

scientific article published on 05 April 2013

Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay.

scientific article

Dual-binding conjugates of diaromatic guanidines and porphyrins for recognition of G-quadruplexes

scientific article published on 10 July 2020

Effects of 8-methylguanine on structure, stability and kinetics of formation of tetramolecular quadruplexes

scientific article published on 27 October 2010

Effects of Six-Membered Carbohydrate Rings on Structure, Stability, and Kinetics of G-Quadruplexes

Energetics of strand-displacement reactions in triple helices: a spectroscopic study.

scientific article

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

Engineering bisquinolinium/thiazole orange conjugates for fluorescent sensing of G-quadruplex DNA.

scientific article

Exclusive platination of loop adenines in the human telomeric G-quadruplex

scientific article

Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

scientific article (publication date: 15 March 2010)

FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA.

scientific article

FRET-MC: A fluorescence melting competition assay for studying G4 structures in vitro

scientific article published on 24 December 2020

Flow cytometric estimation of poly(A)+ RNA by fluorescent in situ hybridization

scientific article published on 01 January 1993

Fluorescence energy transfer as a probe for nucleic acid structures and sequences.

scientific article

Fluorescence intercalator displacement assay for screening G4 ligands towards a variety of G-quadruplex structures

scientific article published on 27 May 2011

Fluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligands

scientific article

Fluorescence-based melting assays for studying quadruplex ligands

scientific article

Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+ solutions by single molecule FRET microscopy

scientific article published on 28 November 2015

Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite

scientific article

From quadruplex to helix and back: meta-stable states can move through a cycle of conformational changes

scientific article

Functionalization of DNA G-Wires for patterning and nanofabrication.

scientific article

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

scientific article published on 11 January 2018

G-Quadruplex formation interferes with P1 helix formation in the RNA component of telomerase hTERC.

scientific article

G-Quadruplexes Light up Localized DNA Circuits.

scientific article published on 30 December 2015

G-Quadruplexes in the Archaea Domain

scientific article published on 21 September 2020

G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy

scientific article published on 14 January 2015

G-quadruplex DNA: a target for drug design

scientific article published on 01 December 1998

G-quadruplex nucleic acids.

scientific article published on 10 August 2010

G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study

scientific article

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

scientific article published on 26 November 2010

G-quadruplex-binding ligand-induced DNA synapsis inside a DNA origami frame

scholarly article in RSC Advances, vol. 4 no. 12, 2014

G-quadruplexes and helicases

scientific article

G-quadruplexes in Prague: a Bohemian Rhapsody.

scientific article published on 13 February 2018

G-quadruplexes in helminth parasites

scientific article published on 01 March 2022

G-quadruplexes unfolding by RHAU helicase

scientific article

G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA.

scientific article

Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes.

scientific article

Guided assembly of tetramolecular G-quadruplexes.

scientific article published on 20 June 2013

HIV-1 nucleocapsid proteins as molecular chaperones for tetramolecular antiparallel G-quadruplex formation

scientific article

Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands

scientific article published on 10 September 2015

High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation

scientific article

Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

article by Anne De Cian et al published February 2007 in Journal of the American Chemical Society

Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound

scientific article

How long is too long? Effects of loop size on G-quadruplex stability

scientific article

Human replication protein A unfolds telomeric G-quadruplexes

scientific journal article

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline

scientific article published on 5 August 2009

Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix

scientific article

Identification of trinucleotide repeat ligands with a FRET melting assay

scientific article

Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro

scientific article

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts

scientific article

Inability of RNA to form the i-motif: implications for triplex formation.

scientific article published on July 1996

Insights into G-Quadruplex–Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding

scientific article published on 06 February 2021

Interaction of an acridine dimer with DNA quadruplex structures.

scientific article

Interaction of human telomeric DNA with N-methyl mesoporphyrin IX.

scientific article published on 23 February 2012

Interaction of telomestatin with the telomeric single-strand overhang.

scientific article

Interactions of cryptolepine and neocryptolepine with unusual DNA structures.

scientific article

Intercalation of ethidium bromide into a triple-stranded oligonucleotide

scientific article

Involvement of G-quadruplex regions in mammalian replication origin activity

scientific article published on 22 July 2019

Kinetics and thermodynamics of G-quadruplexes.

scientific article

Kinetics and thermodynamics of triple-helix formation: effects of ionic strength and mismatches

scientific article published on September 29, 1992

Kinetics of double-chain reversals bridging contiguous quartets in tetramolecular quadruplexes.

scientific article published on 08 May 2006

Kinetics of quadruplex to duplex conversion.

scientific article published on 30 September 2015

Kinetics of tetramolecular quadruplexes

scientific article

Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe

scientific article

Label-free luminescent detection of LMP1 gene deletion using an intermolecular G-quadruplex-based switch-on probe

scientific article

Label-free sensing of pH and silver nanoparticles using an "OR" logic gate

scientific article published on 10 May 2012

Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats.

scientific article

Loop permutation affects the topology and stability of G-quadruplexes

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex

scientific article published on 24 September 2015

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe

scientific article published on 18 May 2015

Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum

scientific article published on 01 May 2019

Meeting report: Fourth international meeting on G-quadruplex Nucleic Acids (Singapore, July 1-4, 2013).

scientific article published on 8 October 2013

Meeting report: Guanosines and quadruplexes (London, September 15-17, 2010)

scientific article published on 26 October 2010

Meeting report: Seventh International Meeting on Quadruplex Nucleic Acids (Changchun, P.R. China, September 6-9, 2019)

scientific article published on 05 November 2019

Mercury–thymine interaction with a chair type G-quadruplex architecture

article by Nicole M Smith et al published 2012 in Chemical Communications

Molecular recognition of quadruplex DNA by quinacridine derivatives.

scientific article published on May 2003

Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy

scientific article published on 14 August 2019

Multicarbazole scaffolds for selective G-quadruplex binding

scientific article published on 01 August 2018

NMR based model of human telomeric repeat G-quadruplex in complex with 2,4,6-triarylpyridine family ligand

scientific article

Natural and pharmacological regulation of telomerase

scientific article

Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition

scientific article published on 25 January 2006

Nucleic acid structure: a continuing tradition

scientific article

Nucleic acids as targets for antitelomerase agents.

scientific article

Nucleic acids targeted to drugs: SELEX against a quadruplex ligand

scientific article published on 31 May 2011

Orienting tetramolecular G-quadruplex formation: the quest for the elusive RNA antiparallel quadruplex

scientific article

Phenanthroline polyazamacrocycles as G-quadruplex DNA binders

Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes

scientific article

PlasmodiumTelomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds

scholarly article by Anne De Cian published in November 2008

Predicting and understanding the stability of G-quadruplexes

scientific article published on June 2009

Preferential binding of a G-quadruplex ligand to human chromosome ends.

scientific article

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation

scientific article

Quadruplex-based molecular beacons as tunable DNA probes

scientific article published on 01 August 2006

Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome.

scientific article published in June 2018

Quartets in G-major. The First International Meeting on Quadruplex DNA.

scientific article

RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand.

scientific article

Re-evaluation of G-quadruplex propensity with G4Hunter

scientific article

Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or Without Side Chains?

scientific article published on 17 March 2011

Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

scholarly article

Reevaluation of the stability of G-quadruplex structures under crowding conditions.

scientific article published on 17 December 2015

Relations between the loop transposition of DNA G-quadruplex and the catalytic function of DNAzyme

scientific article published on 19 May 2017

Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration

scientific article published on 02 October 2003

Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis.

scientific article

Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle

scientific article

Sequence effects in single-base loops for quadruplexes

scientific article

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

scientific article

Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism

scientific article published on 20 August 2014

Spectroscopic data for the G-quadruplex DNA to duplex DNA reaction

scientific article published on 5 November 2015

Stability of intramolecular quadruplexes: sequence effects in the central loop

scientific article published on 06 July 2009

Stability of telomeric G-quadruplexes

scientific article

Stabilization of novel immunoglobulin switch regions G-quadruplexes by naphthalene and quinoline-based ligands

Structural Dynamics and Polymorphism of Telomeric G-Quadruplex DNA Structures

Structural dynamics of propeller loop: towards folding of RNA G-quadruplex

Structure of two G-quadruplexes in equilibrium in the KRAS promoter

scientific article published on 20 May 2020

Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.

scientific article

TGF-β-induced fibrotic stress increases G-quadruplex formation in human fibroblasts

scientific article published on 15 November 2019

Targeting DNA

scientific article published on 01 August 2011

Targeting DNA

scientific article published on 14 May 2008

Targeting human telomerase for cancer therapeutics.

scientific article

Targeting telomeres and telomerase

scientific article published on 24 July 2007

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

scientific article published on 16 January 2004

Telomerase: a dimeric ménage à trois

scientific article published on 01 September 2007

Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells

scientific article published on October 2011

Tetramolecular quadruplex stability and assembly

scientific article published in January 2013

The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides

scientific article

The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium

scientific article

The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

scientific article published on 01 August 2007

The interaction of an iridium(III) complex with G-quadruplex DNA and its application in luminescent switch-on detection of Siglec-5.

scientific article published on 28 September 2016

The minus 10% syndroma

scientific article published on 23 March 2012

The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo

scientific article published on 08 May 2009

Thermal difference spectra: a specific signature for nucleic acid structures.

scientific article

Thermal melting studies of ligand DNA interactions

scientific article

Thioflavin T as a fluorescence light-up probe for G4 formation

scientific article published on 7 February 2014

Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development

scientific article published on 27 March 2014

Tri-G-Quadruplex: Controlled Assembly of a G-Quadruplex Structure from Three G-Rich Strands

scientific article published on 04 October 2012

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

scientific article published on 18 June 2020

Tridentate N-Donor Palladium(II) Complexes as Efficient Coordinating Quadruplex DNA Binders

scientific article published on 18 October 2011

Triple helix formation with Drosophila satellite repeats. Unexpected stabilization by copper ions.

scientific article published in September 2004

Triple helix structures: sequence dependence, flexibility and mismatch effects

scientific article

Triple helix-specific ligands

scientific article

Triplex- versus Quadruplex-Specific Ligands and Telomerase Inhibition

UV Melting of G-Quadruplexes

scientific article

UV-A-induced decrease in nuclear factor-kappaB activity in human keratinocytes.

scientific article published on March 1999

Ultraviolet-A induces activation of AP-1 in cultured human keratinocytes

scientific article published on April 1996

Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes.

scientific article published on 19 May 2017

Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands

scientific article published on 13 July 2011

Unusual DNA conformations: implications for telomeres

scientific article

[Regulation of telomeres length: making the telomeres accessible?]

scientific article published on 01 January 2005

[Telomeres: a Nobel Prize at the beginning… of the end].

scientific article

hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

scientific article published on 30 November 2021

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