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List of works by Elizabeth Winzeler

3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

scientific article published on 27 June 2017

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle ⬇️

scientific article (publication date: July 1998)

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

scientific article published on 26 October 2015

A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling

scientific article (publication date: June 2004)

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

scientific article

A broad analysis of resistance development in the malaria parasite

scientific article published on 15 June 2016

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

scientific article published on 8 September 2011

A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays.

scientific article published in April 2005

A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings.

scientific article

A key role for lipoic acid synthesis during Plasmodium liver stage development

scientific article published on 05 April 2013

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes

scientific article published in December 1996

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

scientific article (publication date: 14 May 2010)

A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum

scientific article

A systematic map of genetic variation in Plasmodium falciparum

scientific article

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

scientific article

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

scientific article published on 11 February 2022

Advances in Parasite Genomics

Advances in parasite genomics: from sequences to regulatory networks

scientific article

An improbable journey: Creativity helped me make the transition from art to curing malaria

scientific article published in Journal of Biological Chemistry

Aneuploidy—it's more common than you think

scientific article published on 01 July 2000

Antimalarial drug discovery - approaches and progress towards new medicines.

scientific article

Antimalarial drug discovery: progress and approaches

scientific article published on 31 August 2023

Application of High-Density Array-Based Signature-Tagged Mutagenesis To Discover Novel Yersinia Virulence-Associated Genes ⬇️

scientific article published on December 1, 2001

Applied systems biology and malaria.

scientific article

Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

scientific article

Biochips in Malaria for Antiparasitic Discovery

scholarly article published 19 October 2006

CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

scientific article

Cell-based optimization of novel benzamides as potential antimalarial leads

scientific article published on 29 October 2009

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

scientific article published on 8 March 2018

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

scientific article

Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon.

scientific article published on 21 February 2018

Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response

scientific article

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article published on 25 May 2016

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

scientific article published on 06 June 2019

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone

scientific article published on 03 May 2019

Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity

scientific article published on 15 August 2017

Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region.

scientific article published on 15 March 2018

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

scientific article published on 11 July 2017

Direct allelic variation scanning of the yeast genome

scientific article

Direct transfer of whole genomes from bacteria to yeast

scientific article

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

scientific article

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Discovery of gene function by expression profiling of the malaria parasite life cycle

scientific article (publication date: 12 September 2003)

Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

scientific article published on 2 June 2010

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Drug resistance genomics of the antimalarial drug artemisinin

scientific article

Elucidating genetic diversity with oligonucleotide arrays

scientific article

Epidemiology: resistance mapping in malaria

scientific article published in June 2013

Esterase mutation is a mechanism of resistance to antimalarial compounds

scientific article (publication date: 20 January 2017)

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling

scientific article

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

scientific article published on 05 December 2019

Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum

scientific article published in Science

Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.

scientific article published on August 2013

Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity.

scientific article published on 13 July 2007

Fluorescence anisotropy decay of ethidium bound to nucleosome core particles. 2. The torsional motion of the DNA is highly constrained and sensitive to pH.

scientific article published in May 1991

Functional analysis of the yeast genome

scientific article published on 01 December 1997

Functional profiling of the Saccharomyces cerevisiae genome

scientific article (publication date: 25 July 2002)

Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantification of DNA-tagged strains

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

scientific article

Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria

scientific article published on May 2013

Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites

scientific article

Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival

scientific article (publication date: 2010)

Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes

scientific article

Genomic profiling of drug sensitivities via induced haploinsufficiency.

scientific article published on March 1999

Genomics, systems biology and drug development for infectious diseases

scientific article published on 31 October 2007

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

scientific article

Glycophorin alleles link to malaria protection

scientific article

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

scientific article published on 14 August 2017

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

scientific article

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

scientific article published on 17 October 2016

Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites

scientific article published on 30 July 2011

Identification of pathogen genomic variants through an integrated pipeline

scientific article

Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.

scientific article published on 11 September 2013

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

scientific article (publication date: 9 December 2011)

Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

scientific article published on 23 June 2011

Imidazolopiperazines: lead optimization of the second-generation antimalarial agents

scientific article

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

scholarly article

In silico discovery of transcription regulatory elements in Plasmodium falciparum.

scientific article

In silico gene function prediction using ontology-based pattern identification

scientific article

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

scientific article published on 01 December 2019

In vivo profiles in malaria are consistent with a novel physiological state

scientific article published in July 2009

In vivo transcriptional profiling of Plasmodium falciparum

scientific article

In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins

scientific article

Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.

scientific article published on 17 February 2014

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

scientific article published on 16 April 2020

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

scientific article

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

scientific article published on 23 December 2013

Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities ⬇️

scientific article

Large-scale annotation of small-molecule libraries using public databases

scientific article

Large-scale identification of single-feature polymorphisms in complex genomes

scientific article published on March 2003

Large-scale mutagenesis and functional genomics in yeast

scientific article

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages

scientific article published on 6 July 2014

Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays

scientific article

Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance

scientific article

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Malaria research in the post-genomic era

scientific article published in Nature

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

scientific article published in January 2018

Mechanisms of gene regulation in Plasmodium.

scientific article published on August 2007

Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays

scientific article published on 8 September 2005

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

scientific article

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes

scientific article

Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays

scientific article published on 01 September 2002

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

scientific article published on 11 January 2021

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

scientific article (publication date: 20 February 2015)

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

scientific article (publication date: 5 July 2016)

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

scientific article (publication date: 13 February 2013)

Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes

scientific article

Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

scientific article published on 19 March 2019

Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum

scientific article

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

scientific article published on 23 February 2021

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene ⬇️

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

scientific article published on 01 December 2018

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

scientific article published on 14 April 2020

Parallel identification of new genes in Saccharomyces cerevisiae

scientific article published on August 2002

Perspectives: The missing pieces

scientific article published on 25 April 2012

Phenotypic Screens in Antimalarial Drug Discovery

scientific article published on 27 May 2016

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

scientific article

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

scientific article (publication date: 2 November 2007)

Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

scientific article published on 07 April 2016

Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment

scientific article published on 14 March 2007

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

scientific article published on 20 April 2021

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast ⬇️

scientific article

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

scientific article published on 04 March 2020

Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae

scholarly article

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast

scientific article published on 15 December 2016

Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum

scientific article published on 18 January 2007

Replication dynamics of the yeast genome

scientific article published in October 2001

Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples.

scientific article published on 07 February 2017

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

scientific article

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

scientific article published on July 2010

Structure-Activity and Structure-Toxicity Relationships of Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity

scientific article published on 19 February 2019

Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty

scientific article published on 03 February 2020

Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and ha

scientific article

Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class

scientific article published on 31 May 2016

Systems analysis of host-parasite interactions

scientific article

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

scientific article published on 7 November 2018

Target identification and validation of novel antimalarials

scientific article published on June 2011

Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity

scientific article (publication date: 5 December 2014)

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

scientific article

Techniques

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.

scientific article published on 8 December 2020

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

scientific article

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

scientific article published on September 2005

The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast

scientific article

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

scientific article

The paradoxical population genetics of Plasmodium falciparum

scientific article

The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa.

scientific article published on 13 May 2019

Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype

scientific article published in October 1997

Translation of the leaderless Caulobacter dnaX mRNA

scientific article

Treasures and traps in genome-wide data sets: case examples from yeast

scientific article

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

scientific article (publication date: 19 September 2016)

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

scientific article

Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum

scientific article

Using genetic methods to define the targets of compounds with antimalarial activity

scientific article

Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.

scientific article published on 16 February 2018

Using the genome to dissect the molecular basis of drug resistance.

scientific article published on August 2006

Validation of isoleucine utilization targets in Plasmodium falciparum

scientific article (publication date: 25 January 2011)

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

scientific article

Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation

scientific article published on 28 December 2015

Whole genome sequencing analysis of Plasmodium vivax using whole genome capture

scientific article

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

scientific article

malERA: An updated research agenda for malaria elimination and eradication

scientific article published on 30 November 2017

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